There are currently 1094 clinical trials in Rochester, Minnesota looking for participants to engage in research studies. Trials are conducted at various facilities, including Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic - Rochester and Mayo Clinic Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy
NCT06238648
Recruiting
This phase II trial compares epcoritamab to standard practice (observation) for the treatment of patients with B-cell lymphomas who are not in complete remission after treatment with CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy. Epcoritamab is a bispecific antibody. It works by simultaneously attaching to a molecule called CD20 on cancerous B-cells and a molecule called CD3 on effector T-cells, which are a type of immune cell. When epcoritamab binds to CD20 and CD3, it brings t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Primary Mediastinal Large B-Cell Lymphoma, Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
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Ommaya Reservoir Placement for Brain Tumor Biomarker Access
NCT04692337
Recruiting
The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor. The Ommaya reservoir will facilitate a longitudinal access to cerebrospinal fluid (CSF) for analysis of potential biomarkers for brain tumor research and individualized monitoring.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Brain Tumor
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A Clinical Registry of Spontaneous Intracranial Hypotension
NCT05922514
Recruiting
The purpose of this research is to determine the efficacy of paraspinal vein embolization for treatment of digital subtraction myelography (DSM) or CT myelography (CTM) confirmed cerebrospinal fluid (CSF)-venous fistulas so that researchers can inform the development and design of future clinical trials of this technique.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Spontaneous Intracranial Hypotension
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A Prospective Research Investigation of Ischemia Using MCG
NCT06481943
Recruiting
PRISM is a prospective, pilot research study that aims to systematically characterize the usefulness of CardiAQ MCG, a bedside magnetocardiography device, in the evaluation of myocardial ischemia and infarction status.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Acute Coronary Syndrome
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A Study of SPX-303, a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors
NCT06259552
Recruiting
Part 1 of this study is an open-label, dose-escalation, and safety expansion study of an anti-LILRB2 / anti-PD-L1 bispecific antibody SPX- 303 in patients with solid tumors. Part 2 of this study is an indication-specific dose expansion study of SPX-303.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Solid Tumor, HNSCC, RCC, CRC
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An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients with Glioma
NCT06444412
Recruiting
This clinical trial evaluates whether gallium-68 (Ga-68) prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) imaging is useful in differentiating between disease that has come back after a period of improvement (recurrence) or that is growing, spreading, or getting worse (progression) and treatment effect in patients with glioma. Patients with glioma undergo frequent imaging for assessment of disease status. After first-line treatment however,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: WHO Grade 3 Glioma, WHO Grade 4 Glioma
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Impact of Aromatase Inhibitor Therapy on Glucose Homeostasis and Diabetes Risk
NCT06557057
Recruiting
This study assesses the effect of hormone directed treatment for breast cancer on glucose metabolism.
Gender:
FEMALE
Ages:
All
Trial Updated:
09/19/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: HER2-Positive Breast Carcinoma
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Beetroot Juice and Sleep
NCT05864521
Recruiting
The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/18/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Healthy
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Study of Biomarker-Based Treatment of Acute Myeloid Leukemia
NCT03013998
Recruiting
This screening and multi-sub-study Phase 1b/2 trial will establish a method for genomic screening followed by assigning and accruing simultaneously to a multi-study "Master Protocol (BAML-16-001-M1)." The specific subtype of acute myeloid leukemia will determine which sub-study, within this protocol, a participant will be assigned to evaluate investigational therapies or combinations with the ultimate goal of advancing new targeted therapies for approval. The study also includes a marker negativ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Previously Untreated Relapsed Refractory Acute Myeloid Leukemia
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ZIP Study-OL Study of Safety, PK, Efficacy, PD, Immunogenicity of ATB200/AT2221 in Pediatrics Aged 0 to < 18 y.o. w/LOPD
NCT03911505
Recruiting
This is a Phase 3, open-label, multicenter study to evaluate the safety, PK, efficacy, PD, and immunogenicity of Cipaglucosidase Alfa/Miglustat treatment in enzyme replacement therapy (ERT)-experienced and ERT-naïve pediatric subjects with Pompe disease, aged 0 to \< 18 years
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
09/16/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Pompe Disease (Late-onset)
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Obstructive Sleep Apnea Among Somali-Americans
NCT04124848
Recruiting
The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Obstructive Sleep Apnea
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Dexmedetomidine for Intraoperative Shivering in Scheduled Elective Cesarean Delivery
NCT04730609
Recruiting
The purpose of this study is to determine the optimum dose of Dexmedetomidine to stop shivering in 90% of patients who experience shivering during scheduled elective cesarean deliveries.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Shivering, Dose Finding Study
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