There are currently 935 clinical trials in Durham, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Duke University Medical Center, Duke University, Duke Comprehensive Cancer Center and Duke University Health System. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)
NCT06151197
Recruiting
This study will assess the efficacy, safety, and tolerability of EN3835 compared to placebo in the treatment of PFI (also known as Ledderhose disease).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Endo Site 15, Durham, North Carolina
Conditions: Plantar Fibromatosis, Ledderhose Disease
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Cervical Cancer Detection Using Optical Spectroscopy
NCT00900575
Recruiting
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/27/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cervical Cancer
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Collection and Storage of Tissue and Blood Samples From Patients With Cancer
NCT02474160
Recruiting
This study collects and stores tissue and blood samples from patients with cancer. Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help scientists create new and better models to learn about cancer and to test new cancer drugs.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
02/27/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
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Pilot Study for Speculum Free Cervical Cancer Screening
NCT04107181
Recruiting
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
Gender:
FEMALE
Ages:
Between 21 years and 65 years
Trial Updated:
02/27/2025
Locations: Duke University, Durham, North Carolina
Conditions: Cervical Cancer
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Testing a Device for Automatically TRacking Urine and STool in an Inpatient HCT Setting (Project TRUST)
NCT05520346
Recruiting
The purpose of this study is to determine whether a prototype toilet device that we have developed can accurately and automatically track human fluid output from renal and gastrointestinal systems in the hospital. The device includes components that can be outfitted onto existing toilets. In this study, participants hospital room will be outfitted with the prototype toilet device. Participants will use the toilet as usual throughout the duration of their inpatient stay. Sometimes output will be... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/27/2025
Locations: Duke University, Durham, North Carolina
Conditions: Fluid Output
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Repositioning Immunotherapy in VetArans With Lung Cancer
NCT06275360
Recruiting
This study is a multicenter Phase II single arm trial to assess the safety and efficacy of chemotherapy and immunotherapy followed by radiotherapy in patients with unresectable Stage III NSCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2025
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: Non-Small Cell Lung Cancer
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US National TOP Registry
NCT06513091
Recruiting
The objective of this Registry is to collect short and long-term post-transplant clinical outcome data of all donor lungs preserved and assessed on the OCS Lung System and to document the performance of the OCS device in the real-world setting after FDA approval in the US.
Gender:
ALL
Ages:
All
Trial Updated:
02/27/2025
Locations: Duke University, Durham, North Carolina
Conditions: Lung Transplant
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Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease
NCT05150197
Recruiting
The purpose of this study is to test a new way of measuring the peripheral vision (called a visual field test) using a device which can be worn as goggles rather than being a large instrument the patient must sit at. This new visual field test (called VisuALL) is an FDA-approved virtual reality system which has been used in adults and children. This study will compare the performance of the VisuALL to the standard testing for peripheral vision, which is called the Humphrey Visual Field (HVF) tes... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
02/26/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Visual Field Defect, Peripheral
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Exactech Shoulder Post Market Clinical Follow-up Study
NCT05603728
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
02/26/2025
Locations: Duke Department of Orthopedic Surgery, Durham, North Carolina
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
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Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only
NCT05619588
Recruiting
The objectives of this study are to evaluate the performance and safety of the Vantage Total Ankle System. This study will follow subjects for a period of up to 10 years post-surgery.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
02/26/2025
Locations: Duke Department of Orthopaedic Surgery, Durham, North Carolina
Conditions: Ankle Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
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Contraceptive Efficacy Study of Ovaprene
NCT06127199
Recruiting
This will be a multi-center, single arm, open-label study of Ovaprene, a non-hormonal intravaginal ring, to investigate the contraceptive effectiveness, safety and acceptability of Ovaprene.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
02/25/2025
Locations: Carolina Women's Research and Wellness Center, Durham, North Carolina
Conditions: Contraception
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Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer
NCT06636721
Recruiting
The purpose of this study is to develop a brief assessment and need-based behavioral intervention for addressing aging-specific concerns in older adults with lung cancer. The long-term goals of this research include identifying the unique concerns of these patients, providing patients with behavioral skills to address their symptom management needs, and enhancing patient engagement with healthcare specialties targeting aging-specific concerns. In the first phase of this study, participants (12... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/25/2025
Locations: Duke University Health System, Durham, North Carolina
Conditions: Lung Cancer
Register for Updates