There are currently 931 clinical trials in Durham, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Duke University Medical Center, Duke University, Duke Comprehensive Cancer Center and Duke University Health System. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
NCT03808922
Recruiting
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
Gender:
ALL
Ages:
All
Trial Updated:
11/18/2024
Locations: Duke University, Durham, North Carolina
Conditions: Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
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A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
NCT05563766
Recruiting
Esophageal cancer, which has a low 5-year overall survival rate (\<20%) is increasing in incidence. Previous studies have shown that Hedgehog, AKT, and angiogenic signaling pathways are activated in a significant number of esophageal cancers. Itraconazole, a widely used anti-fungal medication, effectively inhibits these pathways. In this multi-site phase II trial, the investigators will evaluate the effect of itraconazole as a neoadjuvant therapy added to standard of care chemoradiation and surg... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Gastroesophageal Junction Carcinoma
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Botensilimab and Balstilimab Optimization in Colorectal Cancer
NCT06268015
Recruiting
This is a single-arm, interventional, pilot clinical trial. Fifteen evaluable patients will have tumor-informed ctDNA testing at baseline and start botensilimab and balstilimab treatment. They will receive botensilimab and balstilimab in 6-week cycles until progression, after which mFOLFOX6 and bevacizumab or panitumumab will be added to the regimen. Subjects will have safety testing at baseline and every two weeks while on study drug. Study treatment with botensilimab and balstilimab, mFOLFOX6,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Duke University, Durham, North Carolina
Conditions: Colorectal Cancer
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Tolerability of an Anesthesia-free Tonometer Tip
NCT06585423
Recruiting
The purpose of this study is to compare the tolerability and comfort of 3 different prototype anesthesia-free tonometer tips with the standard tonometer tip in conjunction with anesthesia. The best-tolerated prototype anesthesia-free tonometer tip will be identified for further development for home tonometry.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Duke Eye Center, Durham, North Carolina
Conditions: Glaucoma
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PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant
NCT03763643
Recruiting
This is a pilot/feasibility, multicenter, randomized, open label, clinical trial to test that hypothesis that plasmapheresis plus rituximab prior to or at the time of kidney transplantation can prevent recurrent FSGS in children and adults.
Gender:
ALL
Ages:
Between 1 year and 65 years
Trial Updated:
11/15/2024
Locations: Duke University, Durham, North Carolina
Conditions: Focal Segmental Glomerulosclerosis
Register for Updates
Mobile Anger Reduction Intervention
NCT06094933
Recruiting
Difficulty controlling anger is the most commonly reported reintegration concern among combat Veterans, especially those with a diagnosis of posttraumatic stress disorder (PTSD). Problematic anger is associated with significant functional impairment. In the current project, the investigators will compare the Mobile Anger Reduction Intervention (MARI) with a health education mobile intervention (HED) among Veterans with PTSD and problematic anger. Participants will be randomized to the MARI or HE... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/15/2024
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: Posttraumatic Stress Disorder, Anger
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The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions
NCT04140344
Recruiting
The purpose of this single-blind, randomized, controlled study is to assess the efficacy of "informative text messages" vs "traditional handouts" provided to lumbar spine surgery patients post-operatively.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Duke Neurosurgery and Duke Orthopedics, Durham, North Carolina
Conditions: Lumbar Spine Degeneration, Lumbar Spine Instability, Lumbar Spondylosis
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Training for Urinary Leakage Improvement After Pregnancy
NCT06411158
Recruiting
This is a multi-center, randomized single-blind nonsurgical trial conducted in approximately 216 primiparous postpartum women at high risk for prolonged/sustained pelvic floor disorders with symptomatic, bothersome urinary incontinence (UI) amenable to nonsurgical treatment. TULIP is a 3-Arm trial with two active interventions (Arms 1 and 2) and a Patient Education control arm (Arm 3). Arm 1 consists of pelvic floor muscle training (PFMT). Arm 2 uses a home biofeedback device (leva®). The prim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Duke University, Duke Division of Urogynecology and Reconstructive Pelvic Surgery, Durham, North Carolina
Conditions: Urinary Incontinence, Delivery Complication
Register for Updates
PK/PD of Digoxin in Infants With SVHD
NCT06613477
Recruiting
The primary participant will be an infant with single ventricle heart disease. This is a research study to learn more about how the medication digoxin, which is routinely prescribed to infants and children with heart disease in pediatric cardiac intensive care units is processed by their bodies and how it may help their cardiac function. The investigators will collect blood or will collect blood samples when bloodwork is checked as part of regular care ("opportunistic"). The investigators will... Read More
Gender:
ALL
Ages:
Between 30 days and 6 months
Trial Updated:
11/13/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Single-ventricle, Infant Conditions, Infant, Newborn, Diseases, Infant, Premature, Diseases
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High Dose Inspiratory Muscle Training in LOPD
NCT05431127
Recruiting
Study Objectives: 1) assess the safety and feasibility of high-dose inspiratory muscle training (IMT) delivered remotely in Late-onset Pompe Disease (LOPD) and 2) determine its effects on respiratory and patient-reported outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Late-Onset Pompe Disease, Lysosomal Disease
Register for Updates
IL13 Signaling in Allergic Asthma
NCT05478824
Recruiting
This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic and non-allergic patients with asthma and obesity and drive significant differential responses to dupilumab. It is further hypothesized that dupilumab will increase interleukin-13 receptor alpha 2 (IL-13Rα2) levels and/or signaling activity on airway epithelial cells iso... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/12/2024
Locations: Duke Asthma Allergy and Airway Center, Durham, North Carolina
Conditions: Asthma, Allergic, Asthma, Obesity
Register for Updates
Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma
NCT05608668
Recruiting
This is a single-center, randomized, SHAM-controlled, parallel assignment, double-masked,8-week interventional study among children aged 8-17 years (not yet 18 years old) of age with obesity and asthma. (n=60), recruited from Duke Health Center Creekstone, to test the effectiveness of inspiratory muscle rehabilitation (IMR) as an acceptable add-on intervention to reduce dyspnea (feeling short-of-breath or breathless) and to promote greater activity in children with obesity and asthma. Clinic to... Read More
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
11/12/2024
Locations: Duke Healthy Lifestyles Clinic, Durham, North Carolina
Conditions: Pediatric Obesity, Pediatric Asthma
Register for Updates