There are currently 942 clinical trials in Durham, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Duke University Medical Center, Duke University, Duke Comprehensive Cancer Center and Duke University health system. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
All
Ages:
Between 17 years and 50 years
Trial Updated:
07/06/2023
Locations: Duke University, Durham, North Carolina
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients
NCT04933435
Recruiting
This is a research study to evaluate change in Quality of Life, as defined by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC C-30), from baseline to 1 month post treatment in two patient cohorts receiving Interventional Radiology Liver Directed Therapies or Hypofractionated Image-Guided Radiation Therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/03/2023
Locations: Durham Veterans Administration Health Care System (DVAHCS), Durham, North Carolina +1 locations
Conditions: Liver Cancer
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Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx
NCT04667585
Recruiting
The purpose of this study is to use intra-treatment 18FDG-PET/CT during definitive radiation therapy for human papillomavirus (HPV)-related oropharyngeal cancer (OPC) as an imaging biomarker to identify and select patients with a favorable response for chemoradiation dose de-escalation. This study will prospectively evaluate the clinical outcomes for patients undergoing dose de-escalation.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/03/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Oropharynx Cancer
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Intraoperative OCT Guidance of Intraocular Surgery II
NCT03713268
Recruiting
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes. The investigators believe this technology will enable novel ophthalmic and other microsurgeries not possible due to current limitations in surgical visualization.
Gender:
All
Ages:
4 weeks and above
Trial Updated:
06/29/2023
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment, Retinal Disease, Preretinal Fibrosis, Cataract, Ocular Tumor, Strabismus, Healthy
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Hyperbaric Oxygen and Outcome After Below Knee Amputations
NCT04717557
Recruiting
This study is being conducted to assess the utility of hyperbaric oxygen as an adjunctive treatment to reduce postoperative complications. It is hypothesized that HBO2 given in the immediate postoperative period will reduce postoperative complications in patients undergoing below-the-knee amputations. The objective of this study will be to compare treatment and standard care groups, randomly created of eligible patients, to compare their postoperative complications and to assess their postoperat... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/29/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Amputation; Postoperative, Sequelae
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Stool Transplants to Treat Refractory Clostridium Difficile Colitis
NCT02127398
Recruiting
It has been shown that restoration of the normal makeup of the bowel bacterial population is the most effective way to treat recurrent colitis due to Clostridium difficile. Restoration of the normal bowel bacterial population is best done by transplanting stool from a healthy donor. The investigators wish to transplant stool from healthy donors to treat recurrent C. difficile colitis by incorporating the stool into capsules that are administered by the oral route.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/29/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Clostridium Difficile Colitis
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Midwest TXTXT Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence
NCT05783297
Recruiting
This research study uses a cluster randomized controlled trial design to evaluate the effectiveness of Treatment Text (TXTXT) intervention on adherence and viral load suppression at 3- and 6- months post intervention initiation for youth and young adults with HIV. A total of 12 clinics will be randomized into one of the following two conditions: Comparison Arm (n=6 clinics)- Clinics randomized to the comparison arm will have participants receive the standard of care for 3 months, followed by a... Read More
Gender:
All
Ages:
Between 16 years and 35 years
Trial Updated:
06/29/2023
Locations: Duke University, Durham, North Carolina
Conditions: HIV Infections
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Macrophage Regulation of Ozone-Induced Lung Inflammation
NCT05773001
Recruiting
The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
06/28/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: SARS-CoV-2 Pneumonia
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Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset
NCT05685745
Recruiting
The goal of the Tiny Baby Collaborative Multicenter Inventory of Neonatal-Perinatal Interventions (MINI) minimum dataset is to serve as a registry detailing the outcomes and practices for all deliveries and infants admitted to intensive care at 22-23 weeks' gestation at participating hospitals.
Gender:
All
Ages:
Between 0 years and 1 year
Trial Updated:
06/26/2023
Locations: Duke University, Durham, North Carolina
Conditions: Infant, Extremely Premature, Obstetric Labor, Premature, Premature Birth, Intensive Care, Neonatal, Intensive Care Units, Neonatal
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Motivating Occupational Virtual Experiences In Therapy for Kids
NCT04510857
Recruiting
A rater-blinded randomized controlled trial (RCT) will be conducted to compare the efficacy of MOVE-IT use in a remotely supervised home exercise program (HEP) to usual care for recovery of upper extremity (UE) function in children with hemiplegia.
Gender:
All
Ages:
Between 4 years and 12 years
Trial Updated:
06/26/2023
Locations: Duke University, Durham, North Carolina
Conditions: Virtual Reality, Occupational Therapy
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Eat Well Produce Benefit for Diabetes and Food Insecurity
NCT05896644
Recruiting
The goal of this clinical trial is to assess the impact of participation in Eat Well for diabetes patients who are at risk of food insecurity. The main questions it aims to answer are: whether there is a difference in Haemoglobin (Hb) A1c measurements and emergency department (ED) utilization between the Eat Well and control groups up to 18 months post-program completion. whether there are differences in cardiometabolic health-related outcomes for Eat Well participants. Participants in the pro... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/23/2023
Locations: Duke University Health System, Durham, North Carolina
Conditions: Diabetes Mellitus, Food Insecurity
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Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer
NCT04559139
Recruiting
This phase II/III trial compares the effect of adding chemotherapy before and after surgery versus after surgery alone (usual treatment) in treating patients with stage II-III gallbladder cancer. Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before surgery may make the tumor smaller; therefore, may reduce the exten... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Stage II Gallbladder Cancer AJCC v8, Stage IIA Gallbladder Cancer AJCC v8, Stage IIB Gallbladder Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8, Stage IIIA Gallbladder Cancer AJCC v8, Stage IIIB Gallbladder Cancer AJCC v8
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