There are currently 1342 clinical trials in Columbus, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Nationwide Children's Hospital, Ohio State University Comprehensive Cancer Center, Ohio State University and The Ohio State University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: The Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
Register for Updates
MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients
NCT04651634
Recruiting
The proposed study in patients with previously untreated locally advanced head and neck squamous cell carcinoma (HNSCC) is designed to evaluate the efficacy and safety of three different doses of MIT-001 compared to the placebo in prevention of oral mucositis (OM) in patients with HNSCC who are undergoing concurrent chemoradiotherapy (CCRT).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/21/2023
Locations: James Cancer Hospital Solove Research Institute, Columbus, Ohio
Conditions: Oral Mucositis, Head and Neck Squamous Cell Carcinoma
Register for Updates
Evaluating Modifiable Biomarkers for the Prediction of Immunotherapy Response and Toxicity
NCT04954885
Recruiting
This study evaluates gut microbiome and functional status as modifiable biomarkers in predicting immunotherapy response and toxicity in patients with stage IV non-squamous non-small cell lung cancer receiving pembrolizumab alone or in combination with pemetrexed and carboplatin on the INSIGNIA trial. The goal of this study is to estimate the extent to which future interventions that seek to rationally modify the gut microbiome and/or functional status can improve outcomes.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/20/2023
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Lung Non-Squamous Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
Register for Updates
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Spinal Muscular Atrophy (SMA)
Register for Updates
Hairy Cell Leukemia Patient Data Registry
NCT02560883
Recruiting
The overall objective is to develop a clinical data registry that can be used to facilitate research with the ultimate goal of reducing the morbidity and/or mortality and improving the quality of life of patients diagnosed or living with hairy cell leukemia. With approximately 1,000 new cases of this rare disease identified in the US each year, HCL represents 2% of all cases of leukemia in adults. Considering the rarity of this chronic leukemia, the Hairy Cell Leukemia Foundation (HCLF), in part... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2023
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Leukemia, Other
Register for Updates
AFFECT Study for Patients With Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, and Ventriculitis
NCT05649904
Recruiting
The goal of this clinical trial is to evaluate efficacy and safety of evacuation of cerebrospinal fluid, blood, and harmful bacteria from the intraventricular, subdural and subarachnoid spaces by Active Controlled Irrigation and Drainage (IRRAflow) compared to Passive External Ventricular Drainage (EVD). Subjects with intraventricular hemorrhage, subarachnoid hemorrhage, subdural bleeding, and ventriculitis will be randomized to receive the IRRAflow device or EVD device and followed for one mon... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Ventriculitis
Register for Updates
Auditory Neural Function in Implanted Patients With Usher Syndrome
NCT04906135
Recruiting
Usher syndrome (USH) causes extensive degeneration in the cochlear nerve (CN), especially in CN fibers innervating the base of the cochlea. As the first step toward developing evidence-based practice for managing implant patients with USH, this study evaluates local neural health, as well as the neural encoding of temporal and spectral cues at the CN in implanted patients with USH. Aim 1 will determine local CN health in patients with USH by assessing the sensitivity of the electrically evoked c... Read More
Gender:
All
Ages:
Between 1 year and 85 years
Trial Updated:
04/03/2023
Locations: Gina Hounam, Columbus, Ohio +1 locations
Conditions: Usher Syndrome, Cochlear Implantation
Register for Updates
Stellate Ganglion Block to Augment Trauma-focused Therapy Among Veterans With PTSD
NCT05107752
Recruiting
Our long-term goal is to improve clinical outcomes among patients receiving psychological treatment for posttraumatic stress disorder (PTSD). The primary objective of this project is to examine if stellate ganglion block (SGB) improves outcomes among military personnel and veterans receiving cognitive processing therapy (CPT), an empirically-supported psychological treatment for PTSD. To accomplish this objective, we will enroll adult military personnel and veterans with a current diagnosis of P... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: The Ohio State University, Columbus, Ohio
Conditions: PTSD, Trauma and Stressor Related Disorders, Trauma, Psychological, Post Traumatic Stress Disorder
Register for Updates
Blue Light Cystoscopy With Cysview® Registry
NCT02660645
Recruiting
Registry study to gather more information on the current use of Blue Light Cystoscopy with Cysview (BLCC) in urologists' practices.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Ohio State University Wexner Medical Center, Columbus, Ohio +1 locations
Conditions: Bladder Cancer
Register for Updates
Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
NCT01522183
Recruiting
Post-marketing safety data on patients treated and untreated with eculizumab or ravulizumab.
Gender:
All
Ages:
All
Trial Updated:
03/23/2023
Locations: Clinical Trial Site, Columbus, Ohio
Conditions: Atypical Hemolytic-Uremic Syndrome
Register for Updates
DNA-Guided Second Line Adjuvant Therapy For High Residual Risk, Stage II-III, Hormone Receptor Positive, HER2 Negative Breast Cancer
NCT04567420
Recruiting
A randomized, Phase II trial of circulating tumor DNA-guided second line Adjuvant therapy for high Residual risk, stage II-III, Estrogen Receptor positive, HER-2 negative breast cancer (DARE)
Gender:
All
Ages:
All
Trial Updated:
03/20/2023
Locations: The Ohio State University Wexner Medical Center James Cancer Hospital, Columbus, Ohio
Conditions: Breast Cancer
Register for Updates
Promoting Healing Of Nerves Through Electrical Stimulation
NCT04662320
Recruiting
This study is evaluating a new therapeutic use of electrical stimulation to promote nerve healing and improve functional recovery following surgical intervention for nerve compression. A single dose of the therapeutic stimulation is delivered as part of the surgical intervention to address compression of the ulnar nerve at the elbow.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/20/2023
Locations: The Ohio State Univeristy - Department of Plastic and Reconstructive Surgery, Columbus, Ohio
Conditions: Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies
Register for Updates