Oregon is currently home to 1216 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Portland, Eugene, Medford and Clackamas. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Allogeneic NK T-Cells Expressing CD19 Specific CAR in B-Cell Malignancies
Recruiting
This study is a multi-center study to evaluate the safety of KUR-502 in subjects with refractory/relapsed B-cell NHL or leukemia (ALL or CLL).
Gender:
ALL
Ages:
Between 3 years and 75 years
Trial Updated:
05/16/2023
Locations: OHSU - Knight Cancer Center, Portland, Oregon
Conditions: NHL, Relapsed, Adult, B-cell Lymphoma, B-cell Leukemia, DLBCL - Diffuse Large B Cell Lymphoma, ALL, Adult B Cell, ALL, Childhood, CLL/SLL
KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
Functional and Structural Imaging for Glaucoma
Recruiting
The specific aims of the clinical studies are to: * Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion. * Validate wide-field OCT and OCT angiography parameters to improve early glaucoma detection. * Simulate visual field results by combining structural and angiography OCT data. * Assess abilities of above technologies and OCT-derived parameters on predicting glaucoma detection, conversion, and progression.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
04/17/2023
Locations: Oregon Health & Science University, Casey Eye Institute, Portland, Oregon
Conditions: Glaucoma
Eye Pressure Lowering Surgery
Recruiting
The purpose of this study is to determine if lowering the pressure inside the eye improves blood flow to the eye.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/17/2023
Locations: OHSU, Portland, Oregon
Conditions: Glaucoma
A Scaleable Video Coaching Intervention for Opioid-using Mothers
Recruiting
This study will adapt and evaluate a novel, innovative, and highly scalable parenting intervention that employs video coaching to target responsive parenting, Filming Interactions to Nurture Development (FIND), among women who have been referred to or are in treatment for opioid misuse/addiction.
Gender:
ALL
Ages:
50 years and below
Trial Updated:
03/27/2023
Locations: University of Oregon, Eugene, Oregon
Conditions: Child Behavior, Parent-Child Relations, Substance Use, Substance Abuse
Phase 1/2a Study of SQ3370 in Patients With Advanced Solid Tumors
Recruiting
The purpose of this study is to evaluate the safety, tolerability, and preliminary activity of SQ3370 in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2023
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Cancer
Pediatric Cervical Spine Clearance: A Multicenter Prospective Observational Study
Recruiting
A prospective multicenter observational study, led by Dr. Katie Russell of Intermountain Primary Children's Hospital, that will examine the sensitivity, specificity, negative, and positive predictive values of CT scan and plain films in diagnosing cervical spine injury that requires treatment. This study is funded by the Primary Children's Hospital foundation.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
11/01/2022
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Cervical Spine Fracture
Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects
Recruiting
The purpose of this study is to study the long term safety and effectiveness of an artificial iris prosthesis for the treatment of iris defects.
Gender:
ALL
Ages:
3 years and above
Trial Updated:
10/21/2022
Locations: Oregon Eye Associates, Eugene, Oregon
Conditions: Full Aniridia, Partial Aniridia
CERENOVUS Neurothrombectomy Devices Registry
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Cerebral Stroke
Clinical and Genetic Analysis of ROP
Recruiting
Retinopathy of Prematurity (ROP) is a vascular disease affecting the retinas (back of the eye) of low birth weight infants. Although it can be treated effectively if diagnosed early, it continues to be a leading cause of childhood blindness in the United States and throughout the world. The investigators feel that this study will result in specific knowledge discovery about ROP, as well as general knowledge about how image-based data and genetic data can be combined to better understand clinical... Read More
Gender:
ALL
Ages:
1 year and below
Trial Updated:
04/18/2022
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Retinopathy of Prematurity
Pilot Study of BCAA on Sleep
Recruiting
Individuals will be recruited from the VA Portland Health Care System and the community affiliated with Oregon Health \& Science University. Traumatic brain injury status will be assessed as a contributing factor. Subjects will be randomized to one of 3 groups (BCAA or one of 2 placebo conditions) and instructed to consume study product twice daily for 21 days. Self-report questionnaires, wrist actigraphy, pressure pain testing, and cognitive function will be assessed pre and post the experiment... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
04/04/2022
Locations: VA Portland Health Care System, Portland, Oregon
Conditions: Sleep Disorder, Traumatic Brain Injury
Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans
Recruiting
The primary purpose of this project is to determine the effect of morning bright light therapy (MBLT) on sleep in Veterans with traumatic brain injury (TBI). Secondarily, the project aims to identify blood-based brain biomarkers (BBBM) associated with sleep in Veterans. Specific Aim 1. Determine the effect of MBLT on sleep quality in Veterans (primary outcome). Specific Aim 2. Determine the effect of MBLT on downstream effectors of improved sleep, including cognition, mood, and quality of life... Read More
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
04/04/2022
Locations: Portland VA Medical Center, Portland, Oregon
Conditions: Traumatic Brain Injury