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Pain Paid Clinical Trials in Pennsylvania
A listing of 56 Pain clinical trials in Pennsylvania actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
13 - 24 of 56
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Clinical Trial Phase
The state of Pennsylvania currently has 56 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Philadelphia, Pittsburgh, Hershey and Allentown.
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People who may be candidates for this procedure:
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¹ Kandzari DE, et al. J Am Coll Cardiol. Nov 7, 2023;82(19):1809-1823.
Conditions:
High Blood Pressure
High Blood Pressure (& [Essential Hypertension])
High Blood Pressure (Hypertension).
Hypertension
Essential Hypertension
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Conditions:
Healthy
Healthy Volunteer Study
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📋 5 providers ranked by true monthly cost
💵 Options starting as low as $149/month
🏥 Only licensed providers using FDA-registered pharmacies
⭐ Real Trustpilot scores included — including the ones with mixed reviews
🔒 Includes cancellation policy warnings so you don't get stuck
Conditions:
Weight Loss
Morbid Obesity
Featured Trial
Rheumatoid Arthritis (RA) Clinical Research Study
Recruiting
The Ntrust-2 study is a clinical research study evaluating an investigational cell therapy, called NKX019, in adults living with rheumatoid arthritis (RA).
The Ntrust-2 study
The Ntrust-2 study is part of a broad effort of the global research community to develop more treatment options for people living with rheumatoid arthritis.
What is NKX019?
NKX019 is an investigational cell therapy being studied for rheumatoid arthritis (RA). It is designed to target and remove the cells that may trigger harmful antibodies, which attack the body’s own tissues in these conditions.
Who can join this study?
You may be eligible to participate in this study if you:
- Are 18 to 75 years old
- Have been diagnosed with rheumatoid arthritis (RA)
- Have received prior autoimmune disease treatments that may have not worked well for you
Compensation
If you are eligible and choose to participate, you will receive NKX019 and health assessments from a team with expertise in caring for people living with autoimmune disease. Costs for travel, lodging, childcare, and meals will be covered when you and your care partner go to the study clinic. Compensation for study participants and your care partner may also be available.
The Ntrust-2 study
The Ntrust-2 study is part of a broad effort of the global research community to develop more treatment options for people living with rheumatoid arthritis.
What is NKX019?
NKX019 is an investigational cell therapy being studied for rheumatoid arthritis (RA). It is designed to target and remove the cells that may trigger harmful antibodies, which attack the body’s own tissues in these conditions.
Who can join this study?
You may be eligible to participate in this study if you:
- Are 18 to 75 years old
- Have been diagnosed with rheumatoid arthritis (RA)
- Have received prior autoimmune disease treatments that may have not worked well for you
Compensation
If you are eligible and choose to participate, you will receive NKX019 and health assessments from a team with expertise in caring for people living with autoimmune disease. Costs for travel, lodging, childcare, and meals will be covered when you and your care partner go to the study clinic. Compensation for study participants and your care partner may also be available.
Conditions:
Rheumatoid
Rheumatoid Arthritis
Arthritis
Rheumatoid
Rheumatoid Arthritis (RA)
Featured Trial
Healthy Participants Needed (Colonoscopy + Cancer Screening)
Recruiting
Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.
Conditions:
Healthy
Healthy Volunteers
Healthy Subjects
Healthy Volunteer
Healthy Participants
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Risks may include surgical, device, and stimulation-related complications. See important safety info: https://83b.co/tlcbld
Conditions:
Overactive Bladder
Urinary Incontinence
Idiopathic Overactive Bladder
Incontinence
Healthy
Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
Recruiting
This research is being conducted to see if using an injectable contraception, Depot Medroxyprogesterone Acetate (Depo-Provera), can reduce the pain experienced by women with sickle cell disease.
Participants in this study will be adult women with sickle cell disease who regularly experience sickle cell pain. They will complete a 3-month "baseline "with no use of hormonal contraception, and then a 3-month follow-up after receiving an injection of Depo-Provera. Participants will complete 6 to 7 i... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
07/23/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sickle Cell Disease (SCD), Vaso-Occlusive Pain Episode in Sickle Cell Disease
Observational Study to Evaluate the Efficacy of Sustained QUTENZA® Use in Painful Diabetic Peripheral Neuropathy
Recruiting
The purpose of this post-market observational study is to provide real-world evidence to support the repeated use of QUTENZA in patients with PDPN and to evaluate the potential for pain and concomitant medication use reduction.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/22/2025
Locations: Center for Interventional Pain and Spine, Bryn Mawr, Pennsylvania +2 locations
Conditions: Peripheral Diabetic Neuropathy, Painful Diabetic Neuropathy
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Recruiting
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP). This pilot trial will test the feasibility of the study design and provide reassurance regarding the tolerability and safety of lacosamide used concomitantly with opioids in this patient population to reduce the condition known clinically as opioid-induced hyperalgesia (OIH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia, Opioid Use Disorder, Opioid-Related Disorders, Opioid Dependence, Chronic Abdominal Pain, ERCP, Pancreatic Surgery
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
Recruiting
The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2025
Locations: Altoona Center For Clinical Research, Duncansville, Pennsylvania
Conditions: Obesity, Overweight, Chronic Low Back Pain (CLBP)
Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma
Recruiting
This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiatio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2025
Locations: University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: Bone Pain, Metastatic Malignant Neoplasm in the Bone, Plasma Cell Myeloma
Cervical Spine Focused Treatment for Patients With Persistent Concussion Symptoms and Neck Pain
Recruiting
Assess the feasibility of recruiting, enrolling and randomizing patients with concussion symptoms and neck pain to receive manual therapy and cervical rehabilitative exercises in addition to standard concussion treatment.
In the usual care workflow provided at the participating concussion clinic, cervical spine rehab is not typically introduced until after week 4. The rationale is that neck pain is often a self-limiting condition that may resolve spontaneously, without the need for specific cer... Read More
Gender:
ALL
Ages:
Between 12 years and 50 years
Trial Updated:
07/08/2025
Locations: UPMC sports medicine, Pittsburgh, Pennsylvania
Conditions: Brain Concussion, Neck Pain
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
Recruiting
This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv).
The research study is testing two different interventions along with usual clinical care:
1. Pain Self-Management (PSM): an educational program in which individuals with chronic pain work with a trained pain coach and a pain peer to explore strategies to effectively manage the daily problems that arise from chronic pain.
2. Patient-Oriented Dosing (POD):... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: UPMC Latterman Family Health Center, McKeesport, Pennsylvania +3 locations
Conditions: Opioid Use Disorder, Chronic Pain
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/25/2025
Locations: Suburban Research Associates, Media, Pennsylvania
Conditions: Diabetic Peripheral Neuropathic Pain
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: Center for Interventional Pain & Spine, Exton, Pennsylvania
Conditions: Chronic Pain
Resilience Coaching for Adolescents With Chronic Musculoskeletal Pain
Recruiting
The goal of this clinical trial is to learn about resilience coaching in adolescents with chronic musculoskeletal pain. The main questions it aims to answer are to 1) determine how helpful resilience coaching is for teens with chronic musculoskeletal pain, 2) which participants are best suited for resilience coaching, and 3) barriers and facilitators to implementing resilience coaching as part of routine clinical care. Participants will complete survey measures and participate in the resilience... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
06/10/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pain, Chronic, Pain Syndrome, Psychological
Sevoflurane's Effect on Neurocognition Study
Recruiting
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
05/29/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Anesthesia, Pain, Amnesia
Adolescent Outcomes of Post-operative Opioid EXposure
Recruiting
The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associated with risk factors for opioid use disorder (ROUD) in the 12 months following major surgery with opioid exposure among adolescents aged 12-17. Participants will be asked to complete electronic surve... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
05/29/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Opioid Use Disorder, Pain, Chronic
13 - 24 of 56