There are currently 1184 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Alleghany General Hospital and Children's Hospital of Pittsburgh UPMC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC
NCT06295731
Recruiting
This seamless phase 2/3 randomized controlled study will evaluate the efficacy and safety of the hexavalent OX40 agonist antibody INBRX-106 combined with the anti-PD-1 antibody pembrolizumab versus pembrolizumab (+ placebo in phase 3) as first-line treatment for patients with locally advanced recurrent or metastatic head and neck squamous cell carcinoma (R/M HSNSCC) incurable by local therapies, expressing PD-L1 with a combined proportion score (CPS) ≥20.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
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Strategy Training for Individuals With Unilateral Neglect
NCT06400147
Recruiting
It is common for individuals after stroke to have a cognitive perceptual impairment called unilateral spatial neglect (neglect). Individuals with neglect have difficulty paying attention to one side of their body or one side of the environment and therefore experience difficulty performing daily activities. There are a lack of effective treatments for neglect and new interventions are needed to help reduce disability for these individuals. Metacognitive strategy training (strategy training) is a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Stroke, Neglect, Hemispatial
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The Protrieve PROTECTOR Study
NCT06495996
Recruiting
The Protrieve PROTECTOR Study is a prospective, single-arm, multicenter study of the Protrieve Sheath.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Venous Thromboembolism, Deep Venous Thrombosis
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AuriculoTherapy NeuroImaging
NCT06825390
Recruiting
This is a clinical study of patients who have low back pain (for at least 6 months). The goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain. There are 4 total study visits, divided into two pairs of visits that occur before and 5-7 days after receiving either a real or sham auriculotherapy treatment. The cryo-IQ device will be used, to stimulate 7 small areas on both ears with a focused jet of cold as a small amoun... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Low Back Pain, Chronic Low-back Pain, Back Pain, Low, Lumbar Disc Disease, Lumbar Discogenic Pain, Lumbar Pain Syndrome, Lumbar Post-Laminectomy Syndrome, Back Pain Lower Back Chronic, Back Pain Without Radiation, Pain;Back Low;Chronic
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Near-InfraRed Spectroscopy of Auricular Stimulation
NCT06825364
Recruiting
This is a single-visit non-invasive study of healthy volunteer subjects. Brain activity will be measured with infra-red light sensors attached to a cap worn on the head, while both ears are gently stimulated with plastic filaments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Healthy Male and Female Subjects, Healthy Volunteer Study
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Trial to Evaluate Acasunlimab and Pembrolizumab Combination Superiority Over Standard of Care Docetaxel in Non-Small Cell Lung Cancer (ABBIL1TY NSCLC-06)
NCT06635824
Recruiting
This is a multicenter, randomized, open-label, international, Phase 3 trial to evaluate the efficacy and safety of acasunlimab in combination with pembrolizumab versus docetaxel (standard of care) in participants with programmed death ligand 1 (PD-L1)-positive metastatic non-small cell lung cancer (NSCLC) who have been treated with programmed cell death protein 1 (PD-1)/PD-L1 inhibitor and platinum-containing chemotherapy, administered either in combination or sequentially in the metastatic sett... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: PD-L1-positive Metastatic NSCLC
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Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Moderatetosevere Asthma.
NCT06609239
Recruiting
This is a phase 2, open-label extension study to evaluate the long-term safety and efficacy of lunsekimig in adult participants with moderate-to-severe asthma who have previously completed the parent study. After completion of the parent study, eligible participants will be offered the opportunity to participate in the long-term extension (LTE) study with lunsekimig. The study duration will be up to 100 weeks with a treatment duration being up to 96 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Allergy & Clinical Immunology Associates Pittsburgh- Site Number : 8400007, Pittsburgh, Pennsylvania
Conditions: Asthma
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Voiceitt for People With Impairments in Speech
NCT06874322
Recruiting
The primary objective of this pilot study is to evaluate the feasibility and preliminary effectiveness of the Voiceitt app in improving communication for individuals with speech impairments due to conditions such as cerebral palsy (CP), stroke, Amyotrophic Lateral Sclerosis (ALS), or Parkinson's disease.
Gender:
ALL
Ages:
13 years and above
Trial Updated:
08/04/2025
Locations: Center for Assistive Technology, Pittsburgh, Pennsylvania
Conditions: Speech Impairment, Speech Disorder
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Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
NCT07043803
Recruiting
The goal of this study is to reduce Anticholinergic Medication (ACM) in persons with psychoses or serious mental illness, when these medications are no longer needed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Comprehensive Recovery Services (Pittsburgh) of Western Psychiatric Hospital, Ambulatory Clinics and Residential Programs - UPMC, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Schizophenia Disorder, Schizoaffective Disorder, Bipolar Disorder, Psychiatric Disorders
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Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
NCT05124808
Recruiting
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
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Transdermal Estrogen in Women With Anorexia Nervosa
NCT03875378
Recruiting
Randomized, placebo-controlled study investigating the use of physiologic, transdermal estrogen for low bone mass in adult women with anorexia nervosa.
Gender:
FEMALE
Ages:
Between 19 years and 45 years
Trial Updated:
08/02/2025
Locations: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Conditions: Anorexia Nervosa
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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
NCT01042379
Recruiting
The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2025
Locations: University Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma, TNBC - Triple-Negative Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, Hormone Receptor Positive Tumor, Hormone Receptor Negative Tumor, Early-stage Breast Cancer, Locally Advanced Breast Cancer
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