There are currently 1184 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Alleghany General Hospital and Children's Hospital of Pittsburgh UPMC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
NCT03328078
Recruiting
This is a multi-center, open-label study to evaluate the safety, pharmacokinetics (PK), and anti-cancer activity of oral administration of emavusertib alone or in combination with ibrutinib in adult participants with relapsed or refractory (R/R) hematologic malignancies. This trial will be completed in four parts. In Part A1, emavusertib will be evaluated first in a dose escalating monotherapy setting to establish the safety and tolerability (complete). In Part A2, emavusertib will be evaluated... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: UPMC Hilman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy, Relapsed Primary Central Nervous System Lymphoma, Refractory Primary Central Nervous System Lymphoma
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Imaging CRF X NOP Interactions in CUD
NCT05008146
Recruiting
This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Cocaine Use Disorder
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[C-11]NPA PET-amphetamine in Cocaine Use Disorders
NCT05011760
Recruiting
This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/02/2025
Locations: University of PIttsburgh, Pittsburgh, Pennsylvania
Conditions: Cocaine Use Disorder
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Enhancing Prefrontal Oscillations and Working Memory in Early-course Schizophrenia
NCT05102929
Recruiting
This study will investigate the effects of intermittent Theta Burst Stimulation (iTBS) on natural oscillatory frequency of the dorsolateral prefrontal cortex (DLPFC) and working memory in early-course schizophrenia (EC-SCZ). Transcranial magnetic stimulation (TMS) will be used to evoke oscillatory activity, and EEG will record the responses of EC-SCZ participants. A working memory task will also be incorporated in order to determine how DLPFC natural frequency (NF) is related to working memory p... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
06/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia
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Emicizumab in Patients With Acquired Hemophilia A
NCT05345197
Recruiting
This is a phase II multicenter open-label, single-arm prospective study to evaluate the efficacy of prophylactic emicizumab administered on a scheduled basis to prevent bleeds in patients with acquired hemophilia A (AHA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Hemophilia Center of Western Pennsylvania, Pittsburgh, Pennsylvania
Conditions: Acquired Hemophilia A
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Brain, Emotions, and Mind-Wandering
NCT05345392
Recruiting
Mood lability is an important transdiagnostic problem that is associated with poor psychosocial function and suicidal thoughts, and is a predictor of mood disorder onset, especially in youth at familial risk. Thus, particularly in youth with a family history of mood disorder, an intervention to target mood lability during a key period of development could improve outcomes. This study will allow us to test neurobehavioral mechanisms of a mindfulness-based intervention to target mood lability in e... Read More
Gender:
ALL
Ages:
Between 11 years and 14 years
Trial Updated:
06/02/2025
Locations: Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Mood Disorders
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Characterization of Gastric Evoked Potentials
NCT05924009
Recruiting
This is an exploratory study that will determine and standardize how best to record gastric evoked potentials (GEPs) elicited by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS), by optimizing the TMS parameters and cortical sites necessary to evoke GEPs.
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
06/02/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Healthy
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Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation
NCT05956951
Recruiting
The purpose of this research is to identify differences in brain activity during sleep between health individuals and individuals with schizophrenia, schizophreniform, or schizoaffective disorder. This study will also investigate whether tones played during deep sleep can enhance specific features of sleep and whether enhancing such features is related to an improvement in cognitive performance.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
06/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia
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Treatment With Aspirin After Preeclampsia: TAP Trial
NCT06281665
Recruiting
The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a randomized controlled trial of postpartum low dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. Our central hypothesis is that postpart... Read More
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
06/02/2025
Locations: University of Pittsburgh Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia, Gestational Hypertension, Cardiovascular Diseases, Toxemia, Pregnancy Complications, Vascular Diseases, Hypertension, Pregnancy Induced, Hypertension;Pre-Eclamptic
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Assessing Improvements in Mood and Sleep Trial
NCT06639477
Recruiting
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two different approaches works best to improve things like trouble sleeping, bad moods, and any suicidality. Participants will complete diagnostic interviews, self-report scales, and wear an actigraphy device for the 8 weeks starting at the baseline visi... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Depression, Suicidality, Sleep
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Effectiveness of Brief Intervention in Primary Care for Diverse Young People (Chat)
NCT06699251
Recruiting
Brief motivational interviewing intervention to address alcohol use among diverse teens 12-17.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
06/02/2025
Locations: University of Pittsburgh Medical Center Children's Hospital, Pittsburgh, Pennsylvania
Conditions: Adolescent Drinking, Cannabis Use
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Remote Enhanced Assessment for Care at Home (REACH)
NCT06843564
Recruiting
The goal of this single arm pilot clinical trial is to test the feasibility and acceptability of providing families of infants with kits of tele-peripheral devices to use during telemedicine visits with their usual primary care practice. The main question it aims to answer are: - the feasibility of providing families of infants with a kit to tele-peripheral devices to use during at-home, same-day live-interactive primary care telemedicine visits. Participants will receive a kit with tele-peri... Read More
Gender:
ALL
Ages:
Between 6 months and 9 months
Trial Updated:
06/02/2025
Locations: UPMC Children's Hospital of Pittsburgh Primary Care Center, Pittsburgh, Pennsylvania +1 locations
Conditions: Common Childhood Illnesses
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