There are currently 1184 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Alleghany General Hospital and Children's Hospital of Pittsburgh UPMC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria
NCT05166161
Recruiting
The main purpose of this study is to evaluate the long-term safety of PTC923 in participants with phenylketonuria, and to evaluate the changes from baseline in dietary phenylalanine (Phe)/protein consumption.
Gender:
ALL
Ages:
All
Trial Updated:
05/07/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Phenylketonuria
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Effect of Behavioral Sleep Intervention on Lower Urinary Tract Symptoms in Older Women
NCT05604222
Recruiting
Urgency urinary incontinence (UUI) is common in older people and vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will investigate the role of adding behavioral sleep intervention to the standard pharmacotherapy in treatment of UUI among older adults, and the brain mechanisms involved in continence by evaluating brain changes. This will expand the current knowledge of how the sleep affects bladder control, and better characterize the brai... Read More
Gender:
FEMALE
Ages:
60 years and above
Trial Updated:
05/07/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Urgency Urinary Incontinence, Nocturia
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A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant
NCT05675930
Recruiting
The purpose of this study is to find out whether photobiomodulation/PBM therapy using the Thor LX2.3 therapy system is a safe and effective treatment for oral Graft-Versus-Host Disease/GVHD.
Gender:
ALL
Ages:
4 years and above
Trial Updated:
05/07/2025
Locations: University of Pittsburgh Medical Center (Data Collection Only), Pittsburgh, Pennsylvania
Conditions: Graft-Versus-Host Disease, GVHD, Undefined
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Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
NCT06651580
Recruiting
This clinical trial collects blood, saliva, urine, or stool samples to help identify possible genetic mutations that may increase a person's chance at developing pancreatic cancer. Finding genetic markers among pediatric patients with acute recurrent pancreatitis and chronic pancreatitis may help identify patients who are at risk of pancreatic cancer.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
05/07/2025
Locations: Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Conditions: Chronic Pancreatitis, Exocrine Pancreas Carcinoma, Recurrent Acute Pancreatitis
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Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465
Recruiting
The purpose of the study is to assess whether the REGENETEN™ Bioinductive Implant allows patients to get back to their everyday activities quicker than if the tendon is repaired by the standard repair technique 'Completion and Repair' for surgically treating partial-thickness rotator cuff tears.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Rotator Cuff Injuries
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A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma
NCT03311308
Recruiting
The purpose of this study is to evaluate the effectiveness and safety of the combination of Pembrolizumab (KEYTRUDA®) and the investigational drug, Metformin.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Univ of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Advanced Melanoma
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Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
NCT03970343
Recruiting
The OPTIMIZER Smart Post-Approval Study is a prospective, multi-center, non-randomized, single arm open label study of 620 subjects receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45%
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Allegheny General Hospital, Pittsburgh, Pennsylvania +1 locations
Conditions: Heart Failure
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Evolution of Metabolic and Immune Dysfunction in In-transit Melanoma
NCT04658303
Recruiting
Melanoma in-transit metastases (ITMs) continue to represent a therapeutic dilemma, in that no standard method of treatment has been uniformly adopted. The complexity and heterogeneity of patient and disease characteristics, including the location and number of ITMs presents a barrier to a one size fits all treatment approach. Treatment of patients with limited regional disease remains challenging. Patients are typically treated with a combination of surgery, regional therapy, systemic therapy. D... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Melanoma
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Sofosbuvir/Velpatasvir Treatment of Chronic Hepatitis C During Pregnancy
NCT05140941
Recruiting
This is a multicenter, single arm study of Sofosbuvir/Velpatasvir (SOF/VEL) for treatment of chronic hepatitis C infection during pregnancy. Treatment will be initiated during the second or third trimester in approximately 100 pregnant people. Maternal participants will take one SOF/VEL tablet once daily for 12 weeks (84 days) and followed until 12 weeks after treatment completion (postpartum). Infants will be followed from birth until one year of age. The primary objectives are to evaluate the... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/05/2025
Locations: University of Pittsburgh, Magee Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Hepatitis C, Chronic, Pregnancy; Infection
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Diabetes RElated to Acute Pancreatitis and Its Mechanisms
NCT05197920
Recruiting
The overriding objective of DREAM is to conduct a prospective longitudinal (36 months) observational clinical study to investigate the incidence, etiology, and pathophysiology of diabetes mellitus (DM) following acute pancreatitis (AP).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/05/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Acute Pancreatitis
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Nicotinamide Riboside in Ulcerative Colitis
NCT05561738
Recruiting
This is a randomized, double-blind pilot study of Nicotinamide Riboside (NR) in Pediatric-onset Ulcerative Colitis (UC).
Gender:
ALL
Ages:
18 years and below
Trial Updated:
05/05/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Ulcerative Colitis
Register for Updates
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
NCT05658796
Recruiting
It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members providing peri-operative mood management with advantage of improved peri-operative outcomes, improving saving for the UPMC ISD by hastening the recovery and decreased resource utilization, and addition to the high-value care of UPMC with this holistic approach to patient peri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: UPMC Shadyside, Pittsburgh, Pennsylvania +1 locations
Conditions: Mood Disorders, Anxiety, Depressive Symptoms, Depression, Anxiety Disorders, Anxiety Depression
Register for Updates