There are currently 1192 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Alleghany General Hospital and Children's Hospital of Pittsburgh UPMC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Fitness for Brain Optimization for Late-Life Depression
NCT04670510
Recruiting
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in th... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
10/19/2024
Locations: UPMC Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Depression in Old Age
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Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors
NCT04896697
Recruiting
This is a first-in-human, Phase 1/2, multicenter, open-label study designed to evaluate the safety and tolerability of vilastobart (XTX101) as monotherapy and vilastobart (XTX101) and atezolizumab combination therapy in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: University of Pittsburgh Medical Center- Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Advanced Solid Tumor
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Connected Through Coaching for Flourishing Families
NCT06145451
Recruiting
Despite the known association between the quality of participant relational engagement with service providers and clinical outcomes, limited studies have examined caregiver Relational Responsiveness (RR) as a mechanism to achieve maltreatment prevention program outcomes. Using a realist-informed mixed method approach, this study will examine RR's role in mediating the effects of a community-based maltreatment prevention program, the Family Success Network (FSN) on protective factors against malt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Maltreatment by Parent
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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
NCT01042379
Recruiting
The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: University Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma, TNBC - Triple-Negative Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, Hormone Receptor Positive Tumor, Hormone Receptor Negative Tumor, Early-stage Breast Cancer, Locally Advanced Breast Cancer
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Fear of Recurrence and Stopping Immunotherapy
NCT04761328
Recruiting
The study includes participants experiencing distress with regard to stopping immunotherapy and will utilize cognitive-behavioral therapy to reduce fear of recurrence, depression, and anxiety and improve quality of life.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/18/2024
Locations: UPMC Hillman Cancer Centers, Pittsburgh, Pennsylvania
Conditions: Cognitive Behavioral Therapy
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Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease
NCT05119556
Recruiting
The purpose of this study is to compare the efficacy and safety of a real time video telehealth pulmonary rehabilitation intervention with standard of care in patients hospitalized for an exacerbation of chronic obstructive pulmonary disease (COPD) to determine the impact on hospital readmissions and respiratory morbidity, and to investigate the cost-effectiveness of the intervention.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
10/17/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Chronic Obstructive Pulmonary Disease
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Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
NCT05743244
Recruiting
A multi-center, placebo-controlled, double blind, 1:1:1 randomized control clinical trial testing two different JAK Inhibitors abrocitnib, ritlecitinib, and placebo in subjects with recent onset Stage 3 Type 1 Diabetes within 100 days of diagnosis.
Gender:
ALL
Ages:
Between 12 years and 35 years
Trial Updated:
10/17/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Diabetes Mellitus, Type 1
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Cromoglicate Adjunctive Therapy for Outpatients With Schizophrenia
NCT03794076
Recruiting
This is a double blind adjunctive randomized controlled trial for schizophrenia using cromoglicate.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/16/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizo Affective Disorder
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Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness
NCT05157620
Recruiting
This is a hybrid1, effectiveness-implementation study of yoga-based exercises (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI). The two-arm randomized controlled trial will compare the efficacy of YE compared to the Wellness Lifestyle Program (WLP). Primary outcomes of the study will be self-report and performance-based measures of community functioning, defined in the investigators study as social, leisure, employment, and life skills functioning in t... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/16/2024
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizoaffective, Bipolar Disorder 1
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Biennial CEM in Women with a Personal History of Breast Cancer
NCT06105749
Recruiting
This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.
Gender:
FEMALE
Ages:
Between 30 years and 79 years
Trial Updated:
10/16/2024
Locations: Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Breast Cancer, Breast Neoplasms, Breast Cancer Female, Neoplasms
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The PREDICTOR Study: Assessing Diagnostic Predictors of Airway Collapse in Patients With Obstructive Sleep Apnea
NCT05428839
Recruiting
This study is an exploratory, multicenter study of up to 300 subjects diagnosed with obstructive sleep apnea who are being evaluated for airway surgery. Subjects will undergo standard evaluation for airway surgery as part of standard of care. In addition to the standard airway assessment, a simple, non-invasive measurement of the width of the inside of each subjects mouth will be performed. This measurement takes 2-3 minutes to perform.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Sleep Apnea, Obstructive
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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
NCT02977780
Recruiting
This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : * Abemaciclib * Temozolomide (temodar) * Neratinib * CC115 * QBS10072S
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Glioblastoma
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