There are currently 1184 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Alleghany General Hospital and Children's Hospital of Pittsburgh UPMC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487
Recruiting
This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate safety and efficacy of the Cordella PA Sensor System in NYHA Class II HF patients, where patients have daily access to PAP data. * Treatment Arm (Group 1) * Active Control Arm (Group 2) * Crossover Arm... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: UPMC, Pittsburgh, Pennsylvania
Conditions: Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
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Anticholinergic Deprescription in Schizophrenia
NCT06562608
Recruiting
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with schizophrenia. Individuals identified by clinical services who have unneeded prescriptions benztropine or trihexyphenidyl will be eligible for deprescription and study entry. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will will be ran... Read More
Gender:
ALL
Ages:
Between 40 years and 70 years
Trial Updated:
02/05/2025
Locations: UPMC Western Psychiatric Hospital/University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Schizophrenia, Schizoaffective Disorder
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Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children
NCT03414775
Recruiting
This study evaluates the effects of either Pediasure or Nourish formulas on the gastrointestinal microbiome in critically-ill children. Patients will be randomized to received either Pediasure or Nourish.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
02/04/2025
Locations: Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Conditions: Critical Illness, Dysbiosis, Pediatric ALL
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Molecular Basis of Pediatric Liver Cancer
NCT03959800
Recruiting
The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.
Gender:
ALL
Ages:
Between 0 years and 99 years
Trial Updated:
02/04/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Childhood Liver Cancer, Liver Malignant Tumors, Embryonal Sarcoma of Liver (Disorder), Hepatoblastoma, Hepatocellular Carcinoma, Rhabdoid Tumor of Liver
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PET Image in PAH Patients
NCT05452889
Recruiting
Pulmonary arterial hypertension (PAH) is mortal disease affecting the blood vessels of the lung. Despite its morbid prognosis, PAH is often misdiagnosed or ignored, with an average time of 44 months between onset of symptoms to diagnosis and substantial progression of disease severity. Therefore, a pressing need exists to develop non-invasive diagnostic imaging tools, particularly that can detect early disease stages. Efforts have been made to develop such imaging capabilities through platform... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/03/2025
Locations: Montefiore Hospital Clinical and Translational Research Center, Pittsburgh, Pennsylvania
Conditions: Pulmonary Arterial Hypertension
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Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
NCT05506878
Recruiting
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear. Because the stimulation of the nerves of the ear by the NSS-2 BRIDGE® device (NBD®) has been shown to modulate pain pathways in rodents, decrease abdominal pain in adolescents with inflammatory bile syndrome and due to the results of our preliminary pilot study, the investigators hypothesized that this... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: University of Pittsburgh Medical Center - Magee-Womens Hospital, Pittsburgh, Pennsylvania +3 locations
Conditions: Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain, Liver Transplant
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Sleep Promotion Program Primary Care
NCT06240325
Recruiting
Investigators developed a brief, scalable, behavioral Sleep Promotion Program (SPP) for adolescents with short sleep duration and sleep-wake irregularity, which relies on two individual sessions and smart phone technology to deliver evidence-based strategies. This R34 will test the feasibility and initial effectiveness of the SPP program and provider training via pilot randomized controlled trial (RCT, n=50) comparing SPP to Sleep Psychoeducation, a brief session on healthy sleep habits. Partici... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
02/03/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Sleep, Sleep Disturbance, Insufficient Sleep
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Apimostinel + Automated Neurocognitive Training for Depression
NCT06400121
Recruiting
Apimostinel shows initial promise as a novel rapid-acting antidepressant medication with minimal side effects or safety concerns. Cognitive Training (CT) is a digital intervention that has shown promise in extending the durability of another similar drug (ketamine). This randomized controlled trial will test the efficacy and safety of apimostinel (vs. placebo) for the acute treatment of depression, and will test the potential of CT to enhance and/or extend the durability of apimostinel's antidep... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/03/2025
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Depression
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Moms Managing Attention-Deficit/Hyperactivity Disorder (ADHD) Study
NCT06540547
Recruiting
The study will develop and test a behavioral program for pregnant individuals with Attention-Deficit/Hyperactivity Disorder (ADHD). This behavioral program will include skills for managing ADHD and related symptoms during pregnancy and after delivery and will be taught by a behavioral therapist in OB care settings.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
02/03/2025
Locations: UPMC Magee Women's Hospital, Pittsburgh, Pennsylvania
Conditions: ADHD, Parenting
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The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life
NCT06675344
Recruiting
The purpose of this study it to test the efficacy of a wearable device to improve symptom management and maximize qualify of life in systemic Sclerosis (SSc) patients in a randomized trial. Specifically, we will evaluate if the Apollo Neuro device may improve the two specific symptoms highest ranked by patients as affecting qualify of life (fatigue, Raynaud phenomenon) as co-primary outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: UPMC Arthritis and Autoimmunity Center, Pittsburgh, Pennsylvania
Conditions: Systemic Sclerosis (SSc)
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Nitrous Oxide Neuroimaging
NCT06702631
Recruiting
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
02/03/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Anesthesia, Pain, Amnesia
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Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
NCT04452305
Recruiting
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.
Gender:
MALE
Ages:
All
Trial Updated:
01/31/2025
Locations: Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Infertility, Male, Cancer, Autoimmune Disorder
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