There are currently 1192 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Alleghany General Hospital and Children's Hospital of Pittsburgh UPMC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
NCT02592291
Recruiting
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to those who receive standard of care only.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
09/13/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries, Spina Bifida, Traumatic Brain Injury
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Improving Measurement and Treatment of Post-stroke Neglect
NCT03317860
Recruiting
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Stroke
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Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults with Anxiety and Depression Symptoms
NCT05802004
Recruiting
In this study, the investigators will recruit young adults (ages 18-25 years) with elevated anxiety/depression symptoms and sleep disturbance. Participants will complete two overnights in a sleep lab. During one of the overnights, slow-wave activity will be enhanced by delivering sub-arousal auditory tones during slow-wave sleep using a headband device (Philips SmartSleep or Dreem 2). During the other overnight, tones will not be administered. Cognitive and emotional processes will be evaluated... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
09/12/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Acoustic Stimulation
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Virtual Reality Headset And/or Aromatherapy for Patients Undergoing a Transperineal Prostate Biopsy
NCT06296147
Recruiting
The purpose of this study is to evaluate if a VR headset and/or aromatherapy can be used to reduce patient pain, anxiety, and embarrassment during a transperineal biopsy (TPBx) compared to standard of care (SOC). The primary objective is to evaluate differences in self-reported pain, fear, or embarrassment during and after the procedure between the VR Group, Aromatherapy Group, VR+Aromatherapy Group, and the Control group.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: University of Pittsburgh Medical Center Shadyside Hospital, Pittsburgh, Pennsylvania
Conditions: Prostate Cancer
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Acoustic Waveform Respiratory Evaluation
NCT06512064
Recruiting
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
Gender:
ALL
Ages:
Between 8 years and 65 years
Trial Updated:
09/11/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders, Bronchiectasis, Airway Malacia, Healthy Control
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Promising ROd-cone DYstrophy Gene TherapY
NCT05748873
Recruiting
This is a two-step, multicenter, Phase I/II study including an open-label dose-escalation phase (Step 1) and a three-arm, controlled, double-masked, randomized extension phase (Step 2), in subjects with advanced RCD due to a mutation in the RHO, PDE6A, or PDE6B gene.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: UPMC Eye Center, Pittsburgh, Pennsylvania
Conditions: Retinitis Pigmentosa
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Romosozumab Use to Build Skeletal Integrity
NCT05058976
Recruiting
The purpose of this study is to find out if one year of romosozumab (Evenity®), a monthly injection given in the arm under the skin, prior to an infusion of zoledronic acid Reclast®, works to treat bone loss and prevent it from worsening in older women (ages 65 and older) who have osteoporosis and reside in long-term care (LTC) facilities.
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
09/09/2024
Locations: UPMC Senior Communities, Pittsburgh, Pennsylvania
Conditions: Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Fracture
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First In Human Study of CX-801 in Advanced Solid Tumors
NCT06462794
Recruiting
The purpose of this first-in-human study, CTMX-801-101, is to characterize the safety, tolerability, and antitumor activity of CX-801 as monotherapy and in combination with pembrolizumab in adult participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: University of Pittsburgh Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Adult
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Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines
NCT02432378
Recruiting
This study will evaluate the immunologic and potential clinical effectiveness of intensive locoregional sequential intraperitoneal (IP) cisplatin (IPC) with intravenous (iv) paclitaxel followed by peritoneal infusion of a chemokine modulatory (CKM) regimen composed of a cocktail of IP rintatolimod and interferon-alpha (IFNα) for patients with advanced stage ovarian cancer (III-IV) at primary neoadjuvant setting. In the safety phase I phase, we determined the tolerable dose of IPC-CKM. In this p... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/06/2024
Locations: UPMC CancerCenter at Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania +1 locations
Conditions: Cancer of Ovary, Cancer of the Ovary, Neoplasms, Ovarian, Ovarian Cancer, Ovary Cancer, Ovary Neoplasms
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Triheptanoin for Children with Primary-Specific Pyruvate Dehydrogenase Complex (PDC) Deficiency
NCT06340685
Recruiting
This is a medical research study to test a medication in patients with a disease called Pyruvate Dehydrogenase Complex (PDC) Deficiency. The medication is triheptanoin, which is currently FDA approved for the treatment of Long-Chain Fatty Acid Oxidation Disorders. Previous research suggests that triheptanoin may also be effective in the treatment PDC Deficiency. This study will investigate the safety and efficacy (how well it works) of triheptanoin in patients with PDC Deficiency.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
09/04/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pyruvate Dehydrogenase Complex Deficiency
Register for Updates
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies
NCT03056794
Recruiting
Children and adults with pyruvate dehydrogenase complex deficiency (PDCD) are participating in a research study seeking to better understand the genetic causes, symptoms, usefulness of current treatments, and outcomes for these disorders. The research project involves completing a questionnaire about the individual or family's medical history and experiences with PDCD, review of medical records by the researchers, and in some cases, advanced genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/04/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pyruvate Dehydrogenase Complex Deficiency Disease
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Mechanisms Underlying Impaired Diabetic Wound Healing
NCT00777712
Recruiting
The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood derived cells) versus wound derived cells will also be studied.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
09/04/2024
Locations: University of Pittsburgh - McKeesport, Pittsburgh, Pennsylvania +2 locations
Conditions: Non-healing Wounds, Diabetes
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