There are currently 651 clinical trials in Charleston, South Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Medical University of South Carolina, GSK Investigational Site, Hollings Cancer Center at Medical University of South Carolina and Medical University of South Carolina (MUSC). Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
NCT04541108
Recruiting
This is a multi-center, open-label Phase 0 Master Protocol designed to study the localized pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME) when administered intratumorally in microdose quantities via the CIVO device in patients with surface accessible solid tumors for which there is a scheduled surgical intervention. CIVO stands for Comparative In Vivo Oncology. Multiple substudies will include specified investigational agents and combinations to be evaluat... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: Sarah Cannon Research Institute, Charleston, South Carolina
Conditions: Solid Tumor
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Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
NCT05080673
Recruiting
This trial examines colorectal cancer incidence in participants with 1 to 2 non-advanced adenomas randomized to surveillance colonoscopy at 10 years compared to participants randomized to surveillance colonoscopy at 5 and 10 years.
Gender:
All
Ages:
Between 50 years and 70 years
Trial Updated:
04/15/2024
Locations: Ralph H Johnson VA Medical Center, Charleston, South Carolina
Conditions: Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
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A Trial of Transplanting Hepatitis C Kidneys Into Hepatitis C-Negative Kidney Recipients
NCT04075916
Recruiting
The Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER-NEXT] study will include adult kidney transplant candidates without hepatitis C virus (HCV) infection on the transplant waiting list who will consent to kidney transplantation from a deceased donor infected with HCV, followed by treatment with a direct acting antiviral. The one-year allograft function and one-year risk of CMV infection will be compared between THINKER-NEXT kidney transplant recipients and matched reci... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: End Stage Renal Disease
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Amplatzer Amulet LAAO vs. NOAC
NCT04226547
Recruiting
The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term NOAC therapy. The clinical investigation is a prospective, randomized, multicenter active control worldwide trial. Subjects will be randomized in a 1:1 ratio between the Amulet LAA occlusion device ("Device Group") and a commercially available NOAC medication ("Cont... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: Roper Hospital, Charleston, South Carolina
Conditions: Atrial Fibrillation, Stroke, Bleeding
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A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
NCT04624659
Recruiting
This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked and cause pain).
Gender:
All
Ages:
Between 12 years and 65 years
Trial Updated:
04/12/2024
Locations: Medical University of South Carolina (MUSC), Charleston, South Carolina
Conditions: Sickle Cell Disease
Register for Updates
Incisional Negative Pressure Wound Therapy for Preoperatively Irradiated Lower Extremity Soft Tissue Sarcoma Wounds
NCT02638298
Recruiting
This is a study comparing two methods of dressing a post operative wound that are currently in practice. One method is a traditional dry gauze dressing. The other method is using a negative pressure dressing that provides gentle suction on the wound. The investigators will attempt to determine how well the use of post-operative negative pressure dressing reduces wound healing problems in patients who have surgery after radiation for a sarcoma in the thigh or leg.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Sarcoma, Cancer, Infectious Disease
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Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)
NCT03554356
Recruiting
A multicenter, prospective, single arm, non randomized clinical trial to evaluate the safety and efficacy of the C2 CryoBalloon Focal Ablation System (CbFAS) for the treatment of persistent dysplasia or intestinal metaplasia (IM) in the tubular esophagus after 3 or more radiofrequency ablations (RFA) for dysplastic BE, or <50% eradication of Barrett's Esophagus (BE) after 2 RFA treatments.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Barrett Esophagus, Intestinal Metaplasia, Esophageal Dysplasia
Register for Updates
Quality of Pediatric Resuscitation in a Multicenter Collaborative
NCT02708134
Recruiting
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Gender:
All
Ages:
Between 0 years and 17 years
Trial Updated:
04/12/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cardiac Arrest, Cardiopulmonary Arrest
Register for Updates
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
NCT00904241
Recruiting
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
Gender:
All
Ages:
30 years and below
Trial Updated:
04/12/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma, Stage 4 Neuroblastoma, Stage 4S Neuroblastoma
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Safety, Tolerability and Efficacy of QRX003 Lotion in Subjects With Netherton Syndrome
NCT05521438
Recruiting
This study has been designed to determine the safety, tolerability and efficacy of QRX003 lotion 2%, 4% QAM or 4% BID in subjects with Netherton Syndrome (NS) in comparison to vehicle
Gender:
All
Ages:
14 years and above
Trial Updated:
04/11/2024
Locations: Site #3, Charleston, South Carolina
Conditions: Netherton Syndrome
Register for Updates
Phase 3 Clinical Study of AK112 for NSCLC Patients
NCT05184712
Recruiting
A Randomized, Double-blind, Multi-center, Phase III Clinical Study of Ivonescimab (SMT112 or AK112) or Placebo Plus Pemetrexed and Carboplatin in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer Who Have Progressed on or Following Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI) Treatment (HARMONi)
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Hollings Cancer Center, Charleston, SC, Charleston, South Carolina
Conditions: Non-Squamous Non-small Cell Lung Cancer
Register for Updates
The National Myelodysplastic Syndromes (MDS) Study
NCT02775383
Recruiting
Multi-center study enrolling patients suspected or newly diagnosed with myelodysplastic syndromes (MDS), myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) overlap disorder, or idiopathic cytopenia of undetermined significance (ICUS). Participants will be followed long term. Clinical data, blood, and tissue samples will be collected to establish a biorepository to facilitate the study of the natural history of MDS.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Ralph H Johnson VA Medical Center, Charleston, South Carolina
Conditions: Myelodysplastic Syndromes (MDS)
Register for Updates