There are currently 651 clinical trials in Charleston, South Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Medical University of South Carolina, GSK Investigational Site, Hollings Cancer Center at Medical University of South Carolina and Medical University of South Carolina (MUSC). Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer
NCT03418961
Recruiting
This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cardiotoxicity, HER2/Neu Positive, Metastatic Malignant Neoplasm in the Brain, Recurrent Breast Carcinoma, Stage IV Breast Cancer AJCC v6 and v7
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Safety, Tolerability and Efficacy of QRX003 Lotion in Subjects With Netherton Syndrome
NCT05521438
Recruiting
This study has been designed to determine the safety, tolerability and efficacy of QRX003 lotion 2%, 4% QAM or 4% BID in subjects with Netherton Syndrome (NS) in comparison to vehicle
Gender:
All
Ages:
14 years and above
Trial Updated:
04/11/2024
Locations: Site #3, Charleston, South Carolina
Conditions: Netherton Syndrome
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Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
NCT00736749
Recruiting
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
Gender:
All
Ages:
All
Trial Updated:
04/10/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
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Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
NCT03007147
Recruiting
This randomized phase III trial studies how well imatinib mesylate works in combination with two different chemotherapy regimens in treating patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia (ALL). Imatinib mesylate has been shown to improve outcomes in children and adolescents with Philadelphia chromosome positive (Ph+) ALL when given with strong chemotherapy, but the combination has many side effects. This trial is testing whether a different chemother... Read More
Gender:
All
Ages:
Between 1 year and 21 years
Trial Updated:
04/10/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia, T Acute Lymphoblastic Leukemia
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Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCD
NCT04930445
Recruiting
This registry is an observational study designed to evaluate the effect of Oxbryta in individuals with SCD in a real-world setting.
Gender:
All
Ages:
4 years and above
Trial Updated:
04/10/2024
Locations: Medical University of South Carolina Shawn Jenkins Women's and Children's Hospital, Charleston, South Carolina +1 locations
Conditions: Sickle Cell Disease
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Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry
NCT01915511
Recruiting
This registry will collect data on the strategies used to achieve a diagnosis of Idiopathic Pulmonary Fibrosis (IPF) and Chronic Fibrosing Interstitial Lung Disease with Progressive Phenotype (ILD) and the treatment and management efforts applied throughout study follow-up, clinical outcome events and patient reported outcome data. Blood samples will be collected periodically throughout the study for use in future research efforts. For participants with non-IPF, chronic fibrosing ILD with progre... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
04/09/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
Register for Updates
Screening Women With Prior HPV for Anal Neoplasia
NCT05217940
Recruiting
The goal of this single arm trial is to prospectively evaluate screening methods for anal cancer precursors in HIV uninfected women with a history of lower genital tract neoplasias and cancers.
Gender:
Female
Ages:
35 years and above
Trial Updated:
04/09/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: HPV-related Lower Genital Tract Neoplasias, HPV-related Anal Neoplasias, Early Stage Lower Genital Tract Cancers
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A Study of TCD601 in de Novo Renal Transplant Recipients
NCT05669001
Recruiting
The purpose of this study is to evaluate the safety and efficacy of TCD601 in combination with Belatacept when compared to standard of care immunosuppression therapy in de novo renal transplant patients.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/09/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Renal Transplantation
Register for Updates
Smell Training and Trigeminal Nerve Stimulation for COVID-related Smell Loss
NCT05855369
Recruiting
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss. This study aims to determine the efficacy of two at-home treatments, smell training and non-invasive trigeminal nerve stimulation. This study requires participants to conduct daily at-home treatment sessions, attend three in-person study visits at the MUSC Department of Psychiatry and Behavioral Sciences,... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/08/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Smell Dysfunction, Olfactory Disorder, Long COVID
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US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair
NCT04852783
Recruiting
The purpose of this trial is to gather data on the safety and effectiveness of the Contour /Contour 021 System in the treatment of wide-necked bifurcated saccular, intracranial aneurysms for submission to FDA in support of a premarket approval application for the device.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/08/2024
Locations: Alejandro Spiotta, Charleston, South Carolina
Conditions: Aneurysm, Intracranial
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SVC Occlusion in Subjects With Acute Decompensated Heart Failure
NCT03836079
Recruiting
Safety and performance evaluation of the preCARDIA System for patients with ADHF.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/08/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Acute Decompensated Heart Failure, Acute Heart Failure, Congestive Heart Failure, Heart Diseases
Register for Updates
Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder
NCT05858346
Recruiting
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/05/2024
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Social Anxiety Disorder
Register for Updates