There are currently 651 clinical trials in Charleston, South Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Medical University of South Carolina, GSK Investigational Site, Hollings Cancer Center at Medical University of South Carolina and Medical University of South Carolina (MUSC). Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Monitored Anesthesia Care vs. General Anesthesia for Transcatheter Aortic Valve Replacement
Recruiting
This study is being done to evaluate the impact that monitored anesthetic care (MAC) versus general endotracheal anesthesia (GETA) has on hospital length of stay, rate of ICU admission, and procedural mortality for patients undergoing Transcatheter Aortic Valve Replacement (TAVR). Also, the investigators hope to determine if the use of Transesophageal Echocardiography (TEE) during GETA impacts device success. Adult patients undergoing transfemoral approach TAVR for aortic valve stenosis may be e... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Transcatheter Aortic Valve Replacement
Transcranial Direct Current Stimulation for Post-stroke Motor Recovery
Recruiting
This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function. The stimulation technique is called transcranial direct current stimulation (tDCS). The treatment uses direct currents to stimulate specific parts of the brain affected by stroke. The adjunctive rehabilitation therapy is called "modified Constraint-Induced Movement Therapy" (mCIMT). During this therapy the subject will wear a mitt on... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke, Ischemic, Motor Activity, Upper Extremity Paralysis
STARS (Smoking Treatment And Remote Sampling) Study
Recruiting
This is a research study to find out if a smoking cessation medications, either varenicline or nicotine replacement products (patches or lozenges), are effective when given to smokers, remotely, as a one-time sample. Participants will either receive a sample of varenicline, nicotine patches and lozenges, or neither. This will be decided randomly. Participants have a 50%chance of receiving varenicline, a 25% chance of receiving nicotine products, and a 25% chance of receiving neither. If the par... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Smoking, Smoking Cessation, Tobacco Smoking, Cigarette Smoking
Understanding the Long-term Impact of COVID on Children and Families
Recruiting
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection. Individuals with and without SARS-CoV-2 infection and with or without PASC symptoms will be followed to identify risk factors and occurrence of PASC. This study will be conducted in the United States and participants will be recruited through inpatient, outpatient, and... Read More
Gender:
All
Ages:
25 years and below
Trial Updated:
03/04/2024
Locations: Medical University of South Carolina (MUSC), Charleston, South Carolina
Conditions: SARS-CoV-2 Infection
Bayer OA Knee Pain Pilot
Recruiting
The objective of this study is to investigate if MRI can be used to evaluated effect of knee artery embolization for knee osteoarthritis. Participants be evaluated in clinic, obtain a knee MRI, undergo embolization of the symptomatic knee, and follow up in clinic at 1, 6, and 12 months after embolization. A second MRI is obtained 6 months after embolization. Participants will keep a record of their pain level and treatment and answer questionnaires at each visit. In addition, this study aims to... Read More
Gender:
All
Ages:
Between 25 years and 90 years
Trial Updated:
03/01/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Osteoarthritis, Knee
Brief, High-dose rTMS for Depression
Recruiting
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of indi... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
03/01/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Depression, Anxiety
Brief Family Involved Treatment Telehealth
Recruiting
Improving alcohol use disorder (AUD) treatment among Veterans is a national public health problem. The rate of AUD among Veterans is twice that of civilians, with up to 50% of Veterans having AUD. Family-based AUD programs are rarely undertaken in busy treatment clinics, and Veterans with problem drinking behavior or AUD are commonly excluded from couple therapies. As a result, there is a need to develop effective family AUD treatments that are both brief and highly accessible to Veterans. The... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
03/01/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Alcohol Use Disorder
Phase 2 Trial of Mesenchymal Stem Cells in Systemic Lupus Erythematosus (MiSLE)
Recruiting
The purpose of this study is to evaluate the efficacy and safety of mesenchymal stem cells (MSCs) obtained from umbilical cords for the treatment of adults with systemic lupus erythematosus (SLE). The goal of this study is to determine if patients receiving an MSC infusion plus standard of care respond better than patients receiving placebo infusion plus standard of care.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/29/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Systemic Lupus Erythematosus
Sponsor-Initiated OCS Heart Perfusion Registry
Recruiting
OHP-II Registry is a sponsor-initiated, multi-center, observational post-approval registry.
Gender:
All
Ages:
All
Trial Updated:
02/29/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Heart Transplant
Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis
Recruiting
The goal of this clinical trial is to test whether adult stem cells, called mesenchymal stem cells (MSCs) collected from the patient's bone marrow can help reduce pain caused by chronic pancreatitis and improve pancreatic function.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/29/2024
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Chronic Pancreatitis, Chronic Pain
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT
Recruiting
This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT). Participants will be randomized to either bone marrow-derived mesenchymal stem cells (MSCs) or control with the standard of care. Participants will be followed for one-year post-transplant.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/28/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Chronic Pancreatitis, Mesenchymal Stem Cells
3D-Printed Versus Laboratory-Fabricated Hyrax Expanders
Recruiting
Maxillary expanders are orthodontic appliances that are commonly used to expand the upper jaw. The purpose of this study will be to compare the effects produced by two different maxillary expanders in children 8-13 years old. The first type of expander is made by hand in an orthodontic laboratory, and the second type of expander is designed on a computer and printed using 3D printers. Both expanders are already used in the MUSC Orthodontics Clinic. The purpose of this study is to see if the 3D p... Read More
Gender:
All
Ages:
Between 8 years and 13 years
Trial Updated:
02/27/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Maxillary Expansion