There are currently 626 clinical trials in Charleston, South Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Medical University of South Carolina, GSK Investigational Site, Hollings Cancer Center at Medical University of South Carolina and Medical University of South Carolina (MUSC). Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)
NCT05582993
Recruiting
The main aim of the study is to evaluate the effectiveness of prophylaxis with vonicog alfa (recombinant von Willebrand factor \[rVWF\]) in children. This study will enroll those participants who have been previously treated with VWF product or with a plasma-derived VWF (pdVWF) product. In this study, participants will be treated with vonicog alfa (rVWF) for 12 months. During the study, participants will visit the study clinic 5 times after treatment initiation.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
03/07/2025
Locations: Medical University of South Carolina (MUSC), Charleston, South Carolina
Conditions: Von Willebrand Disease (VWD)
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LEVosimendan to Improve Exercise Limitation in Patients with PH-HFpEF
NCT05983250
Recruiting
This study will evaluate the efficacy of TNX-103 (oral levosimendan) compared with placebo in subjects with PH-HFpEF as measured by the change in 6-Minute Walk Distance (6 MWD; Day 1 to Week 12).
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/07/2025
Locations: Tenax Investigational Site, Charleston, South Carolina
Conditions: Pulmonary Hypertension
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IV Gallium Study for Patients with Cystic Fibrosis Who Have NTM (ABATE Study)
NCT04294043
Recruiting
The purpose of this study is to assess the safety and tolerability of two 5-day infusion cycles of IV gallium in adult patients with CF who are infected with NTM. Funding Source - FDA Office of Orphan Products Development (OOPD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Nontuberculous Mycobacterium Infection
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CARS: Cannabis and Alcohol Reduction Study
NCT05486234
Recruiting
The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
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Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder
NCT05858346
Recruiting
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Social Anxiety Disorder
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A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
NCT05890729
Recruiting
A phase 1b/2 study of XTMAB-16 in patients with pulmonary sarcoidosis
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Xentria Investigative Site, Charleston, South Carolina
Conditions: Pulmonary Sarcoidosis
Register for Updates
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
NCT06118502
Recruiting
This is a research study to find out if treatment decision making can be improved for smokers who find it difficult to quit with medications. Everyone who participates in this study will receive free product, either nicotine replacement therapies (patches and lozenges), varenicline, or a harm reduction product (e-cigarette) for a full 12 weeks. Most participants will receive some combination of these treatments, depending on individual response to each. All visits and study assessments will be... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cigarette Smoking, Smoking Behaviors, Treatment
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Biomarker Modulation and the Inhibition of NKT1 Cells by Oral GRI-0621 in Patients with IPF
NCT06331624
Recruiting
This is a Phase 2a, randomized, double-blind, multi-center, placebo-controlled, parallel-design, 2-arm study. Approximately 36 subjects with IPF will be randomized in a 2:1 ratio for GRI-0621 4.5mg or Placebo. GRI-0621 dose of 4.5mg will be compared with placebo following once daily oral administration for 12 weeks. Concurrently, a Sub-Study will be conducted, examining the number and activity of NKT cells in BAL, for up to 12 eligible subjects (across various centers). An early-stage patient... Read More
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
03/05/2025
Locations: MUSC Pulmonary Research, Charleston, South Carolina
Conditions: Idiopathic Pulmonary Fibrosis, IPF
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Post-stroke Perturbation Training
NCT04855032
Recruiting
Following a stroke, many individuals have a high risk of falls, which can negatively influence quality of life. Unfortunately, current treatments have not effectively addressed this problem. This study investigates whether two methods of delivering mechanical perturbations during walking have the potential to improve post-stroke walking balance and reduce real-world fall incidence.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke
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Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors
NCT05086757
Recruiting
Pediatric traumatic injury (i.e., injury of sudden onset and severity requiring immediate attention) is the leading cause of death and morbidity among US adolescents and are associated with mental health and health risk outcomes, including posttraumatic stress and depression (affecting between 19-42%), deficits in physical recovery, social functioning and quality of life, which if unaddressed, may contribute to increased use of health care services. The investigators partnered with three accredi... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Traumatic Injury, Technology, Posttraumatic Stress Disorder, Adolescents
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Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes
NCT05896033
Recruiting
In a 2x2 design, current menthol smokers (N=240) will complete a baseline period before being assigned to a cigarette (menthol or non-menthol) and e-cigarette condition (menthol or tobacco-flavored e-liquid) and receiving a 7-week supply of cigarettes and e-cigarettes. The study builds upon our well-established methodology for simulating tobacco regulatory policies. To model a ban, smokers will be instructed to only use their assigned products. Primary outcomes include cigarette smoking and e-ci... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Smoking Prevention and Control
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MITIGAAT: Multifaceted Intervention to Improve Graft Outcome Disparities in African American Kidney Transplants
NCT06023615
Recruiting
This is a randomized study to test a smartphone app that a pharmacist will use to help kidney transplant patients track their medications, blood pressures, and blood sugars in those with diabetes. The goal of this study is to improve care and outcomes in kidney transplant patients and, in particular, help African American patients have better outcomes after transplant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Medication Adherence, Medication Compliance
Register for Updates