South Carolina is currently home to 1231 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Spartanburg and Columbia. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD
NCT05904028
Recruiting
Home optical coherence tomography- guided treatment versus treat and extend for the management of neovascular age-related macular degeneration.
Gender:
All
Ages:
50 years and above
Trial Updated:
06/04/2024
Locations: Hilton Head Retina Institute, Hilton Head Island, South Carolina
Conditions: Neovascular Age-related Macular Degeneration
Register for Updates
Accelerated rTMS for Post-Stroke Apathy
NCT05878457
Recruiting
This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.
Gender:
All
Ages:
40 years and above
Trial Updated:
06/04/2024
Locations: Medical University of South Carolina Brain Stimulation Lab, Charleston, South Carolina
Conditions: Apathy, Stroke Sequelae, Stroke (CVA) or TIA, Stroke/Brain Attack, Motivation, Abulia
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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy
NCT05844982
Recruiting
This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal melanoma with iodine-125 plaque brachytherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: Retina Consultants of Carolina, PA, Greenville, South Carolina
Conditions: Radiation Retinopathy, Visual Impairment
Register for Updates
Evaluation of Tonabersat for DME
NCT05727891
Recruiting
This randomized clinical trial will evaluate the effect of tonabersat compared with placebo on central subfield thickness (CST) in eyes with center-involved diabetic macular edema (CI-DME) and good visual acuity.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: Hilton Head Retina Institute, Hilton Head Island, South Carolina
Conditions: Diabetic Macular Edema
Register for Updates
taVNS or TMS or Both for Depression
NCT05725239
Recruiting
The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/04/2024
Locations: Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina
Conditions: Depression
Register for Updates
Water Vapor Ablation for Localized Intermediate Risk Prostate Cancer
NCT05683691
Recruiting
The purpose of this study is to evaluate the safety and efficacy of the Vanquish Water Vapor Ablation Device ("Vanquish") in treating subjects with Gleason Grade Group 2 (GGG2) localized intermediate-risk prostate cancer.
Gender:
Male
Ages:
50 years and above
Trial Updated:
06/04/2024
Locations: Carolina Urologic Research Center, Myrtle Beach, South Carolina
Conditions: Prostate Cancer
Register for Updates
A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
NCT05629585
Recruiting
This is a Phase III, randomized, open-label, 3-arm, multicenter, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with ICT in participants with stage I to III TNBC with residual invasive disease in the breast and/or axillary lymph nodes at surgical resection following neoadjuvant systemic therapy.
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
06/04/2024
Locations: Research Site, West Columbia, South Carolina
Conditions: Breast Cancer
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Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma
NCT05371093
Recruiting
The goal of this clinical study is test how well the study drug, axicabtagene ciloleucel, works in participants with relapsed/refractory follicular lymphoma
Gender:
All
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: Prisma Health - Upstate, Greenville, South Carolina
Conditions: Relapsed/Refractory Follicular Lymphoma
Register for Updates
A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
NCT05329766
Recruiting
The purpose of this study is to evaluate the safety and preliminary clinical activity of treatment combinations with and without chemotherapy in participants with locally advanced unresectable or metastatic gastric, GEJ, and esophageal adenocarcinoma. Chemotherapy will consist of FOLFOX (oxaliplatin, leucovorin, fluorouracil).
Gender:
All
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: Prisma Health Cancer Institute, Spartanburg, South Carolina
Conditions: Gastrointestinal Tract Malignancies
Register for Updates
Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM
NCT05145491
Recruiting
Vitrectomy to remove an epiretinal membrane (ERM) is one of the most common procedures performed by retinal surgeons. Patients who present with significant macular changes on optical coherence tomography (OCT) but relatively good vision are often advised to defer surgery until vision declines to 20/40 or worse. However, it is unknown if delaying surgery, which allows the foveal architecture to remain compromised and potentially to deteriorate, results in worse visual acuity outcomes than if surg... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
06/04/2024
Locations: Hilton Head Retina Institute, Hilton Head Island, South Carolina
Conditions: Epiretinal Membrane
Register for Updates
Neurostimulation to Improve NOWS Outcomes
NCT05129020
Recruiting
The objective of this study is to determine if tAN therapy can reduce the median number of days of oral morphine administered to an infant after start of treatment.
Gender:
All
Ages:
Between 33 weeks and 1 year
Trial Updated:
06/04/2024
Locations: Medical University of South Carolina - Shawn Jenkins Children's Hospital, Charleston, South Carolina
Conditions: Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome
Register for Updates
Optimizing Tobacco Treatment Delivery for People Living With HIV
NCT05019495
Recruiting
The purpose of this study is to conduct a randomized trial to evaluate a proactive, opt-out model of provider contact to deliver smoking cessation support for people living with HIV compared to standard care support delivered through traditional clinic pathways. Investigators will also evaluate implementation outcomes to identify barriers and facilitators towards future implementation. Investigators hope to define best practices and optimize the delivery of smoking cessation interventions for pe... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
06/04/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Hiv, Smoking, Cigarette
Register for Updates