South Carolina is currently home to 1161 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Columbia and Spartanburg. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder
NCT05858346
Recruiting
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Social Anxiety Disorder
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CARS: Cannabis and Alcohol Reduction Study
NCT05486234
Recruiting
The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
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IV Gallium Study for Patients with Cystic Fibrosis Who Have NTM (ABATE Study)
NCT04294043
Recruiting
The purpose of this study is to assess the safety and tolerability of two 5-day infusion cycles of IV gallium in adult patients with CF who are infected with NTM. Funding Source - FDA Office of Orphan Products Development (OOPD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Nontuberculous Mycobacterium Infection
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Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement
NCT06768762
Recruiting
The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines \[≥150 min/week of MVPA\]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of South Carolina, Columbia, South Carolina
Conditions: Knee Replacement
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A Study to Evaluate the Effect of Budesonide, Glycopyrronium, Formoterol Fumarate (BGF) Metered Dose Inhaler (MDI), Budesonide and Formoterol Fumarate (BFF) MDI and Placebo MDI on Exercise Parameters in Participants With Chronic Obstructive Pulmonary Disease (COPD).
NCT06067828
Recruiting
This study will investigate the effect of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) metered dose inhaler (MDI) compared with Placebo MDI, and Budesonide and Formoterol Fumarate (BFF) MDI on isotime inspiratory capacity (IC) and exercise endurance time.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
03/03/2025
Locations: Research Site, Anderson, South Carolina
Conditions: Chronic Obstructive Pulmonary Disease
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Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)
NCT06052072
Recruiting
This early feasibility study is intended to characterize the impact of pulmonary artery denervation on the quality of life in Heart Failure Patients with Group 2 Pulmonary Hypertension
Gender:
ALL
Ages:
Between 22 years and 85 years
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Group 2 Pulmonary Hypertension, Heart Failure
Register for Updates
MITIGAAT: Multifaceted Intervention to Improve Graft Outcome Disparities in African American Kidney Transplants
NCT06023615
Recruiting
This is a randomized study to test a smartphone app that a pharmacist will use to help kidney transplant patients track their medications, blood pressures, and blood sugars in those with diabetes. The goal of this study is to improve care and outcomes in kidney transplant patients and, in particular, help African American patients have better outcomes after transplant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Medication Adherence, Medication Compliance
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Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes
NCT05896033
Recruiting
In a 2x2 design, current menthol smokers (N=240) will complete a baseline period before being assigned to a cigarette (menthol or non-menthol) and e-cigarette condition (menthol or tobacco-flavored e-liquid) and receiving a 7-week supply of cigarettes and e-cigarettes. The study builds upon our well-established methodology for simulating tobacco regulatory policies. To model a ban, smokers will be instructed to only use their assigned products. Primary outcomes include cigarette smoking and e-ci... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Smoking Prevention and Control
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Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors
NCT05086757
Recruiting
Pediatric traumatic injury (i.e., injury of sudden onset and severity requiring immediate attention) is the leading cause of death and morbidity among US adolescents and are associated with mental health and health risk outcomes, including posttraumatic stress and depression (affecting between 19-42%), deficits in physical recovery, social functioning and quality of life, which if unaddressed, may contribute to increased use of health care services. The investigators partnered with three accredi... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Traumatic Injury, Technology, Posttraumatic Stress Disorder, Adolescents
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Post-stroke Perturbation Training
NCT04855032
Recruiting
Following a stroke, many individuals have a high risk of falls, which can negatively influence quality of life. Unfortunately, current treatments have not effectively addressed this problem. This study investigates whether two methods of delivering mechanical perturbations during walking have the potential to improve post-stroke walking balance and reduce real-world fall incidence.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke
Register for Updates
Integrity Implant System Post Market Clinical Follow-Up Study
NCT06741527
Recruiting
The study design is a prospective, multi-center, single-arm, non-randomized post market clinical follow-up study to confirm the performance, safety and clinical benefit of the Integrity Implant System when used for rotator cuff tear augmentation (with or without repair).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: Steadman Hawkins Clinic of the Carolinas, Greenville, South Carolina
Conditions: Rotator Cuff Tears of the Shoulder
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Trial of DFP-10917 vs Non-Intensive or Intensive Reinduction for AML Patients in 2nd/3rd/4th Salvage
NCT03926624
Recruiting
Phase III, multicenter, randomized study with two arms (1:1 ratio) enrolling patients with AML relapsed/refractory after 2, 3, or 4 prior induction regimens: Experimental arm: DFP-10917 14-day continuous intravenous (IV) infusion at a dose of 6 mg/m²/day followed by a 14-day resting period per 28-day cycles. Control arm: Non-Intensive Reinduction (LoDAC, Azacitidine, Decitabine, Venetoclax Combination Regimens) or Intensive Reinduction (High and Intermediate Dose Cytarabine Regimens), dependin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2025
Locations: Prisma Health Cancer Institute, Greenville, South Carolina
Conditions: Leukemia, Myeloid, Acute
Register for Updates