South Carolina is currently home to 1173 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Spartanburg and Columbia. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Core Semantic Systems TMS
NCT06870552
Recruiting
This study examines the time course of activation of the left anterior temporal lobe (ATL) during lexical processing using Transcranial Magnetic Stimulation (TMS).
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
03/05/2025
Locations: Prisma Health Richland, Columbia, South Carolina
Conditions: Lexical Access in Neurotypicals
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A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
NCT06118502
Recruiting
This is a research study to find out if treatment decision making can be improved for smokers who find it difficult to quit with medications. Everyone who participates in this study will receive free product, either nicotine replacement therapies (patches and lozenges), varenicline, or a harm reduction product (e-cigarette) for a full 12 weeks. Most participants will receive some combination of these treatments, depending on individual response to each. All visits and study assessments will be... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cigarette Smoking, Smoking Behaviors, Treatment
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A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
NCT05890729
Recruiting
A phase 1b/2 study of XTMAB-16 in patients with pulmonary sarcoidosis
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Xentria Investigative Site, Charleston, South Carolina
Conditions: Pulmonary Sarcoidosis
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Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder
NCT05858346
Recruiting
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Social Anxiety Disorder
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CARS: Cannabis and Alcohol Reduction Study
NCT05486234
Recruiting
The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
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IV Gallium Study for Patients with Cystic Fibrosis Who Have NTM (ABATE Study)
NCT04294043
Recruiting
The purpose of this study is to assess the safety and tolerability of two 5-day infusion cycles of IV gallium in adult patients with CF who are infected with NTM. Funding Source - FDA Office of Orphan Products Development (OOPD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Nontuberculous Mycobacterium Infection
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Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement
NCT06768762
Recruiting
The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines \[≥150 min/week of MVPA\]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of South Carolina, Columbia, South Carolina
Conditions: Knee Replacement
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MITIGAAT: Multifaceted Intervention to Improve Graft Outcome Disparities in African American Kidney Transplants
NCT06023615
Recruiting
This is a randomized study to test a smartphone app that a pharmacist will use to help kidney transplant patients track their medications, blood pressures, and blood sugars in those with diabetes. The goal of this study is to improve care and outcomes in kidney transplant patients and, in particular, help African American patients have better outcomes after transplant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Medication Adherence, Medication Compliance
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Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes
NCT05896033
Recruiting
In a 2x2 design, current menthol smokers (N=240) will complete a baseline period before being assigned to a cigarette (menthol or non-menthol) and e-cigarette condition (menthol or tobacco-flavored e-liquid) and receiving a 7-week supply of cigarettes and e-cigarettes. The study builds upon our well-established methodology for simulating tobacco regulatory policies. To model a ban, smokers will be instructed to only use their assigned products. Primary outcomes include cigarette smoking and e-ci... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Smoking Prevention and Control
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Post-stroke Perturbation Training
NCT04855032
Recruiting
Following a stroke, many individuals have a high risk of falls, which can negatively influence quality of life. Unfortunately, current treatments have not effectively addressed this problem. This study investigates whether two methods of delivering mechanical perturbations during walking have the potential to improve post-stroke walking balance and reduce real-world fall incidence.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/03/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke
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Integrity Implant System Post Market Clinical Follow-Up Study
NCT06741527
Recruiting
The study design is a prospective, multi-center, single-arm, non-randomized post market clinical follow-up study to confirm the performance, safety and clinical benefit of the Integrity Implant System when used for rotator cuff tear augmentation (with or without repair).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2025
Locations: Steadman Hawkins Clinic of the Carolinas, Greenville, South Carolina
Conditions: Rotator Cuff Tears of the Shoulder
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Trial of DFP-10917 vs Non-Intensive or Intensive Reinduction for AML Patients in 2nd/3rd/4th Salvage
NCT03926624
Recruiting
Phase III, multicenter, randomized study with two arms (1:1 ratio) enrolling patients with AML relapsed/refractory after 2, 3, or 4 prior induction regimens: Experimental arm: DFP-10917 14-day continuous intravenous (IV) infusion at a dose of 6 mg/m²/day followed by a 14-day resting period per 28-day cycles. Control arm: Non-Intensive Reinduction (LoDAC, Azacitidine, Decitabine, Venetoclax Combination Regimens) or Intensive Reinduction (High and Intermediate Dose Cytarabine Regimens), dependin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2025
Locations: Prisma Health Cancer Institute, Greenville, South Carolina
Conditions: Leukemia, Myeloid, Acute
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