South Carolina is currently home to 1231 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Spartanburg and Columbia. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder
NCT06102200
Recruiting
The Overcome II study is a randomized controlled trial among adults receiving sublingual buprenorphine to help prevent or reduce illicit drug use. The study outcomes will be compared between three treatment arms: (1) sublingual buprenorphine only, which is the standard-of-treatment (2) sublingual buprenorphine with a computer-based cognitive behavior therapy for substance use disorders (CBT4CBT), (3) sublingual buprenorphine with CBT4CBT and peer recovery coaching. The primary outcome of interes... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/20/2023
Locations: Greenville Health System, Greenville, South Carolina
Conditions: Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
Register for Updates
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
NCT05766813
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank diagnostic criteria, who are experiencing wearing off symptoms and levodopa-induced dyskinesia.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
10/20/2023
Locations: Clinical Site, Rock Hill, South Carolina
Conditions: Parkinson Disease
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Together Everyone Achieves More (TEAM) Trial
NCT05519696
Recruiting
The Together Everyone Achieve More (TEAM) Physical Activity trial evaluates the efficacy of a group-based social affiliation intervention (vs. a standard group-delivered physical activity comparison program) for increasing physical activity among inactive African American women. Using a group cohort randomized design implemented at community centers across five years, the primary aim of this study is to evaluate the efficacy of the 10-week TEAM-PA group-based intervention (vs. comparison program... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
10/18/2023
Locations: College of Nursing, University of South Carolina, Columbia, South Carolina
Conditions: Physical Activity
Register for Updates
Cold Atmospheric Plasma Device Extension Study
NCT05937672
Recruiting
Patients between 4-21 years of age with at least one wart or molluscum lesion are eligible to participate in this study. The duration of the study is a minimum of 4 weeks with the maximum duration of monthly treatments for one year, depending on lesion clearance. The number of lesions will be chosen by the dermatologist. Patients who opt to participate will receive non-thermal, or cold, atmospheric plasma to treat all lesions selected. Safety profile as well as changes in size, pain and appearan... Read More
Gender:
All
Ages:
Between 4 years and 21 years
Trial Updated:
10/17/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Verruca Vulgaris, Molluscum Contagiosum
Register for Updates
ITM vs QL for Pediatric Open Lower Abdominal Procedures
NCT05506930
Recruiting
Patients between the ages of 12 months and 11 years who are undergoing an open lower abdominal procedure will be randomized to receive intrathecal morphine, or bilateral quadratus lumborum block. The investigators will compare the effect that intrathecal morphine and quadratus lumborum blocks have on the duration of pain control as demonstrated by charted pain scores and morphine equivalents in the first 48 hours. This study will also assess the side effects of each intervention such as nausea a... Read More
Gender:
All
Ages:
Between 12 months and 11 years
Trial Updated:
10/17/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Pain Control, Ureteral Reimplantation, Pediatrics, Intrathecal Morphine
Register for Updates
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
NCT03860883
Recruiting
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Cutaneous Melanoma, Stage II
Register for Updates
Implementing and Evaluating the Integration of Physical Activity Into a Major Health System and Connecting Patients to Physical Activity Programs.
NCT06073041
Recruiting
Multiple case study trial examining the adoption, implementation, and reach of eligible patients visiting participating Prisma Health primary care clinics and receiving a referral to a 12-week evidence-informed physical activity (PA) program hosted at local community PA facilities.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/16/2023
Locations: Prisma Health, Greenville, South Carolina
Conditions: Chronic Disease, Exercise, Physical Activity
Register for Updates
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
NCT04061746
Recruiting
The goal of this study is to determine the safety and efficacy of fresh metabolically active allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) for the treatment of new-onset type 1 diabetes (T1D) and to understand the mechanisms of protection. If proven effective, such a strategy can be used as a therapeutic option for T1D patients and potentially other autoimmune disorders.
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
10/13/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Diabetes Mellitus, Type 1
Register for Updates
Mindful Walking Program for Older African Americans
NCT06085196
Recruiting
The goal of this clinical trial is to understand the beneficial role of mindful walking in sustaining cognitive health in African American older adults who have elevated risk of developing neuropsychological diseases. The main question it aims to answer is "Does a multi-session mindful walking intervention lead to promising signals of sustaining cognitive health in vulnerable AA older adults?" The researchers in this 2-arm randomized controlled trial will compare the mindful walking group with a... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
10/12/2023
Locations: University of South Carolina, Columbia, South Carolina
Conditions: Cognitive Function, Aging Well, Behavior, Health
Register for Updates
Study to Evaluate IMP9064 as a Monotherapy or in Combination in Patients With Advanced Solid Tumors
NCT05269316
Recruiting
This is a Phase 1/2, multicenter, open-label study to evaluate the safety and efficacy of IMP9064 as monotherapy or in combination with PARP inhibitor Senaparib in patients with advanced solid tumors
Gender:
All
Ages:
18 years and above
Trial Updated:
10/12/2023
Locations: Greenville Hospital System University Medical Center (ITOR), Greenville, South Carolina
Conditions: Solid Tumor, Advanced Solid Tumor
Register for Updates
Advanced Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants
NCT04701437
Recruiting
The overarching goal of this study is to develop a peer-based care coordination intervention for individuals with HCV who were recently released from correctional settings to promote linkage to and retention in HCV care. The investigators will assess the existing barriers and facilitators of HCV treatment initiation, HCV treatment completion, and sustained virologic response among individuals recently released from a U.S. jail or prisons in a randomized control trial. This study will assess the... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/09/2023
Locations: Prisma Health-Upstate, Greenville, South Carolina
Conditions: Hepatitis C
Register for Updates
Rollover Extension Clinical Trial To Evaluate The Long-Term Safety And Efficacy Of KT-301 (Formerly US-APR2020) In Subjects With CKD IV Completing The US-APR2020-01 Study
NCT05407389
Recruiting
This is an Open-Label Rollover Extension Clinical Trial to Evaluate the Long-Term Safety and Efficacy of KT-301 (formerly US-APR2020) in Subjects With CKD IV Who Completed the US-APR2020-01 Study
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/06/2023
Locations: South Carolina Clinical Research, Orangeburg, South Carolina
Conditions: Chronic Kidney Disease stage4
Register for Updates