South Carolina is currently home to 1231 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Spartanburg and Columbia. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis
NCT03987763
Recruiting
This study is to evaluate the safety, the systemic exposure of halobetasol propionate (HP), and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-122 lotion in pediatric participants with moderate to severe plaque psoriasis.
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
07/25/2023
Locations: Bausch Site 05, Spartanburg, South Carolina
Conditions: Psoriasis
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Usability of the Adapted Rower for People With Spinal Cord Injury
NCT05959837
Recruiting
The goal of this clinical trial is to examine usability of a locally built adaptive rower for people with spinal cord injury using an established and tested design. The main questions it aims to answer are: What exercise intensity of activity do users achieve on the rower for steady state and interval rowing plans? What assistance is required for setup and usage of the adaptive rower? What do users think about the ease of use and what is their satisfaction with the adaptive rower? Participant... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: Public Health Research Center, Columbia, South Carolina
Conditions: Spinal Cord Injuries
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Trial of Parkinson's And Zoledronic Acid
NCT03924414
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
NCT05219110
Recruiting
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E. coli (STEC) infection in children and adolescents when compared with traditional approaches (conservative fluid management).
Gender:
All
Ages:
Between 9 months and 21 years
Trial Updated:
07/21/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
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Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders
NCT05064319
Recruiting
This research study evaluates the effects of an FDA-approved medication Gabapentin in individuals with Bipolar Disorder who smoke marijuana. Participants in the study will will be assigned to take either Gabapentin or a matched placebo. Study medication will be taken for 17 days. There will be 5 study visits, with 2 MRI brain imaging scans completed. Questionnaires and clinical interview measures will be completed at study visits along with consistent assessment of potential side effects from st... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
07/20/2023
Locations: Medical University Of South Carolina, Charleston, South Carolina
Conditions: Bipolar Disorder, Cannabis Use, Schizoaffective Disorder, Bipolar Type, Bipolar I Disorder, Bipolar II Disorder, Cannabis Use Disorder, Mild, Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
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A Study of SHR-A1811 in Subjects With Advanced Malignant Solid Tumors
NCT04446260
Recruiting
This is an open-label, two-part study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-A1811 and preliminary anti-tumor efficacy in HER2 expressing or mutated advanced malignant solid tumor subjects.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2023
Locations: Greenville Hospital System, Greenville, South Carolina
Conditions: Advanced Solid Tumors
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Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
NCT01526681
Recruiting
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting. Optional addendums 1 and 2 included in the protocol are intended to establish comparative groups and focused subgroups within the registry.
Gender:
All
Ages:
All
Trial Updated:
07/17/2023
Locations: Sensation-NOW: East Cooper Plastic Surgery, Mount Pleasant, South Carolina
Conditions: Peripheral Nerve Injuries
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Study Comparing Ultrasound-guided FICNB Block to Systemic Analgesia in Treatment of Pediatric Femur Fracture
NCT05947292
Recruiting
The goal of this prospective observational study is to compare pain control strategies in children with femur fractures. Researchers will compare ultrasound-guided fascia iliaca compartment nerve block to IV pain control alone. The main questions it aims to answer are: Are ultrasound-guided fascia iliaca compartment nerve blocks as effective as IV pain control in controlling pain? Do patients who receive an ultrasound-guided fascia iliaca compartment nerve block require less opioid pain medicat... Read More
Gender:
All
Ages:
Between 4 years and 17 years
Trial Updated:
07/12/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Femur Fracture
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Spectral Characteristics of Memory Transformation
NCT05946616
Recruiting
Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-inv... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/07/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Healthy
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Clinical Outcomes Following Implantation of Tecnis Synergy and Symfony Intraocular Lens
NCT05541796
Recruiting
Tecnis Symfony Optiblue (Johnson & Johnson Vision, Santa Ana, CA, Unites States) is a violet light filtering extended depth of focus intraocular lens (IOL) that provides a continuous range of clear vision at far and intermediate. Tecnis Synergy™ IOL (Johnson & Johnson Vision, Santa Ana, CA, Unites States) is another latest United States Food and Drug Administration (USFDA) approved IOL, designed to provide good acuity at far through near distances, reducing the need for spectacles. These IOLs ar... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
07/07/2023
Locations: Waring Vision Institute, Mount Pleasant, South Carolina
Conditions: Cataract
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A Study to Explore if Long-term Use of Mucinex Can Help With Symptoms in Patients With Stable Chronic Bronchitis.
NCT05843669
Recruiting
This is an open-label, multicenter, single-group study designed to determine the effectiveness of Mucinex® when used by patients to treat SCB over a 12-week period, following a 2-week run-in period of no treatment (to establish a baseline).
Gender:
All
Ages:
Between 40 years and 90 years
Trial Updated:
07/06/2023
Locations: Clinical Research of Rock Hill, Rock Hill, South Carolina
Conditions: Chronic Bronchitis
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Early Intervention Following Sexual Assault
NCT04582695
Recruiting
This study is for women who have experienced a sexual assault in the past six weeks and use alcohol. The research involves completing a five week behavioral treatment for stress and alcohol use. Participants will complete surveys during visits. Participants may also be asked to complete brief daily assessments on their smart phones.
Gender:
Female
Ages:
Between 18 years and 65 years
Trial Updated:
07/05/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Ptsd, Alcohol Use Disorder, Sexual Assault and Rape
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