The city of Houston, Texas, currently has 18 active clinical trials seeking participants for Depression research studies.
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: UT Health Science Center at Houston (UTHSC-H), Houston, Texas
Conditions: Treatment Resistant Depression
Telehealth Behavioral Activation for Teens
Recruiting
Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation and skill-building to increase an individual's engagement in valued and enjoyable activities (e.g., socializing with family and friends, exercising, participating in a hobby) in order to improve depressive symptoms. Research has shown that behavioral activation is an effective intervention for depr... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
03/18/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild, Depression Moderate, Depression Severe
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: The University Of Texas Medical School At Houston - UT Center Of Excellence On Mood Disorders, Houston, Texas +1 locations
Conditions: Treatment Resistant Depression
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Recruiting
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
03/04/2024
Locations: McGovern Medical School /ID# 240779, Houston, Texas +2 locations
Conditions: Depression, Bipolar I Disorder
Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD
Recruiting
A Phase 3, randomized, double-blind, placebo-controlled, multicenter trial of REL-1017 in patients with major depressive disorder (MDD).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/15/2024
Locations: Relmada Site, Houston, Texas
Conditions: Major Depressive Disorder, Depression
A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)
Recruiting
This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/15/2024
Locations: Relmada Site, Houston, Texas +1 locations
Conditions: Major Depressive Disorder, Depression
Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes
Recruiting
This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testosterone levels and risk of dementia may help determine the long-term effects of androgen deprivation therapy and may help improve quality of life.
Gender:
All
Ages:
All
Trial Updated:
02/14/2024
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Anxiety Disorder, Depression, Genetic Disorder, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Transdiagnostic Behavioral Therapy for Anxiety and Depression in Autistic Adolescents
Recruiting
This study tests the effectiveness of a transdiagnostic cognitive behavioral therapy for autistic youth with anxiety and/or depression.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
02/13/2024
Locations: Baylor Psychiatry Clinic, Houston, Texas
Conditions: Anxiety, Depression, Emotional Disorder, Autism
Improving Adult Protective Services Client Outcomes: A Stepped-Care Social and Mental Health Engagement Program
Recruiting
The purpose of this study is to ascertain the feasibility and effectiveness of an 8-week social engagement program aimed at reducing depression and increasing social engagement among seniors who are transitioning out of Adult Protective Services (APS) for either elder abuse or self-neglect.
Gender:
All
Ages:
65 years and above
Trial Updated:
02/05/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Depression in Old Age
Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression
Recruiting
The overall objective of the investigators is to assess the therapeutic efficacy and tolerability of Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs) isolated from hematogenous bone marrow for treatment of treatment-resistant bipolar depression patient (TRBD).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/25/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Treatment-resistant Bipolar Depression
A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression
Recruiting
The purpose of this study is to o evaluate the antidepressant efficacy of the PEA in Bipolar Depression and the association between antidepressant response with endogenous cannabinoids and cytokine levels
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/19/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Bipolar Depression
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment Resistant Depression
Recruiting
This study will be conducted as a randomized, double-blind, placebo-controlled, multi-center Phase 2b study. Approximately 180 subjects with treatment resistant depression who meet all eligibility criteria will be enrolled.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/02/2023
Locations: University of Texas Medical School at Houston, Houston, Texas
Conditions: Treatment Resistant Depression