Ketamine for Multiple Sclerosis Fatigue
NCT05378100
Recruiting
The proposed study is a single-center, phase II, randomized, double-blind, parallel-group, active-placebo-controlled trial of intravenous low-dose ketamine in patients with MS fatigue.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/08/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Multiple Sclerosis Fatigue
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Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
NCT05907213
Completed
The purpose of this study is to identify a tolerable dose for postpartum ketamine infusion using a maximum tolerated dose (MTD) 3+3 design. A loading dose over 1 hour will be the MTD variable to be tested, as our data suggest that ketamine side effects occur with the loading dose. The investigators hypothesize that subanesthetic ketamine dose will be well tolerated and any noted side effects will be rated acceptable by postpartum women following cesarean delivery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania
Conditions: Pain, Postoperative, Depression, Postpartum
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Ketamine for the Treatment for Alcohol Use Disorder in the ED
NCT05661669
Withdrawn
The investigators' approach is to conduct a pilot double-blind, placebo-controlled randomized clinical trial with individuals with alcohol use disorder (AUD) seeking inpatient alcohol detoxification in the emergency department (ED) to receive either intravenous ketamine or saline placebo. The primary aim is to evaluate the intervention's safety. The secondary aim is to evaluate the preliminary efficacy of alcohol-related outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Brigham and Women's Faulkner Hospital, Boston, Massachusetts
Conditions: Alcohol Use Disorder
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Ketamine and Kidney Injury in Cardiac Surgery
NCT05268562
Recruiting
The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.
Gender:
ALL
Ages:
70 years and above
Trial Updated:
01/07/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cardiac Surgery
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Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting
NCT06752759
Recruiting
This is a double blind active placebo controlled clinical trial for individuals within an inpatient setting with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
12/23/2024
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Severe Depression, Moderate Depression, Ketamine, Midazolam, Peripheral Nervous System Agents, Central Nervous System Agents, Neurotransmitter Agents, Physiologic Effects of Drugs, Sensory System Agents, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Depressive Symptom, Hypnotics and Sedatives, Anti-anxiety Agents, Tranquilizing Agents, Psychotropic Drugs, Anesthetics Agent, GABA Modulators, GABA Agents
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The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
NCT05786066
Recruiting
The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid receptors (AMPAR).
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
12/19/2024
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: Depressive Disorder, Major Depressive Disorder, Bipolar Disorder, Post Traumatic Stress Disorder, Suicidal Ideation
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Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
NCT05940324
Recruiting
The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/17/2024
Locations: Department of Psychiatry & Behavioral Sciences, Stanford, California
Conditions: Obsessive-Compulsive Disorder
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Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine
NCT04613453
Terminated
The purpose of this study is to determine if intravenous ketamine reduces suicidal thinking compared to an active placebo (midazolam) in adolescents who have treatment resistant depression and a recent history of a suicide event (defined as a suicide attempt, emergency room evaluation for suicidal thinking, or a transition to inpatient care for suicidality in the past 120 days). The primary objective of this study is to determine whether ketamine reduces suicidal ideation (as measured via the C... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
12/16/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Adolescent Suicide, Adolescent Depression
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Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
NCT03470675
Active Not Recruiting
Obstetric anal sphincter injuries (OASIS) encompass both third and fourth degree perineal tears. These tears can have a significant impact on women's quality of life in the short and long term. One of the most distressing immediate complications of this severe perineal injury is perineal pain. Women can also experience postpartum depression, dyspareunia, and altered sexual function after OASIS. This is a randomized controlled trial to study the effects of three interventions (placebo, low dose... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Pain, Postpartum Depression
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Low-Dose Ketamine Infusion During Burn Wound Care
NCT06506565
Recruiting
The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamine infusion during wound care will safely provide pain relief for patients with burn injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Regional One Health, Memphis, Tennessee
Conditions: Burn, Pain, Dissociation, Opioid
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Ketamine Treatment Plans for Chronic Conditions
NCT06038409
Recruiting
A study aimed to assess the efficacy of the various approaches to prescribing Ketamine currently in use off-label. The focus will be to include ketamine within the study plan of those with chronic conditions who are receiving ketamine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/23/2024
Locations: RIVER Telehealth, Helena, Montana
Conditions: Chronic Pain, Depressive Disorder, Anxiety Disorders, Chronic Disease
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RIVER At Home Ketamine Protocols
NCT06070766
Recruiting
Multiple site studies with the recruitment of other sub-investigators and sites. It's sobering to consider how chronic illness makes us more vulnerable to suicidal thoughts and behavior. However, the existence of multiple risk factors also means that there are numerous ways to intervene. Addressing and improving even one risk area will reverberate and improve other areas and the quality of life. RIVER Foundation is completing a 500-participant pilot study researching the safety of oral and nasa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: RIVER Foundation, Bigfork, Montana +1 locations
Conditions: Chronic Condition, Chronic Pain, Chronic Disease, Major Depressive Disorder, Post Traumatic Stress Disorder, Anxiety Disorders
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