Ketamine and Midazolam Infusions for CRPS: Feasibility Study
NCT05945147
Withdrawn
This study will assess the feasibility of administering ketamine plus midazolam or midazolam alone, when infused over 5 days in an outpatient setting, to adults with complex regional pain syndrome (CRPS).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/20/2024
Locations: Stanford University, Stanford, California
Conditions: Complex Regional Pain Syndromes
Register for Updates
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
NCT05796791
Completed
The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for tobacco use disorder when delivered in conjunction with brief motivational enhancement therapy. Participants will receive ketamine assisted motivational enhancement therapy weekly for three weeks and there will be 2 follow up visits. All visits will also consist of questionnaires and saliva samples will be taken. The overall participation will last approximately... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
11/19/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Tobacco Use, Smoking Cessation, Nicotine Dependence
Register for Updates
The Effect of Opioid-Free Anesthesia in TMJ Surgery
NCT04724759
Completed
This study aims is to evaluate the effect of opioid free total intravenous anesthesia on postoperative quality of recovery in patients undergoing oral and maxillofacial surgery (OMF) temporomandibular joint (TMJ) surgery.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Temporomandibular Joint Disorders
Register for Updates
Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in the PED
NCT04150757
Terminated
This will be a descriptive cohort study of intranasal ketamine as the initial analgesic for children with sickle cell disease who present to the pediatric emergency department with vaso-occlusive crisis and are awaiting intravenous line placement.
Gender:
ALL
Ages:
Between 3 years and 25 years
Trial Updated:
11/14/2024
Locations: Jacobi Medical Center, Bronx, New York +1 locations
Conditions: Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Vaso-occlusive Crisis, Ketamine, Intranasal Ketamine, Analgesia
Register for Updates
Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery
NCT04176419
Terminated
The purpose of this study is to determine how a non-opioid pain control regimen, administered before and during surgery, will affect postoperative pain control and total opioid consumption in head and neck cancer participants undergoing cancer surgery with free flap reconstruction.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Postoperative Pain Control, Opioid Consumption
Register for Updates
Ketamine for the Treatment of Depression in Parkinson's Disease
NCT04944017
Recruiting
The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density and reorganization of functional networks underlie ketamine's putative antidepressant effects in PD.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/08/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Parkinson's Disease, Depression
Register for Updates
Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain
NCT05575999
Not Yet Recruiting
Bupivacaine is the most widely used local anesthetic agent across majority of the Cardiac Implantable Electronic device (CIED) implant procedures in the United States. It is hypothesized that the combination of Bupivacaine-Ketorolac-Ketamine (BKK) is more effective in alleviating perioperative and postoperative pain as compared to the use of bupivacaine alone. A few studies have been done to look for the effectiveness of BKK in abdominal surgical procedures. However, no study has been done to e... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Loma Linda University Health, Loma Linda, California +2 locations
Conditions: Pain Management
Register for Updates
Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse
NCT06660017
Not Yet Recruiting
This 2-arm phase II study proposes to determine the efficacy of ketamine oral rinse in pain relief from mucositis in head and neck cancer patients undergoing radiation treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma
Conditions: Head and Neck Cancer
Register for Updates
Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED
NCT03950817
Completed
In the situation when intravenous access is not readily available or unobtainable, sub-dissociative dose ketamine can be administered via intranasal route (IN). The data supporting intranasal route in pediatric patients is somewhat conflicting with regards to the optimum intranasal dose (range 0.75-1 mg/kg) and frequencies of administration. Hence, another non-invasive route such as nebulization via Breath-Actuated Nebulizer which allows a controlled patient-initiated delivery of analgesics in t... Read More
Gender:
ALL
Ages:
Between 7 years and 17 years
Trial Updated:
10/21/2024
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain
Register for Updates
Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer
NCT05156060
Recruiting
This is a study to establish a safe and feasible dose for prophylactic use of a combination of gabapentin and ketamine in head and neck cancer patients undergoing chemoradiation.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/17/2024
Locations: Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Conditions: Head and Neck Cancer, Locally Advanced Head and Neck Carcinoma
Register for Updates
Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
NCT04600089
Recruiting
The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/14/2024
Locations: University of Kentucky Medical Center, Lexington, Kentucky
Conditions: Descending Aortic Dissection, Postoperative Pain, Thoracoabdominal Aortic Aneurysm
Register for Updates
Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD
NCT04889664
Completed
The current pilot project will evaluate the efficacy of adding Written Exposure Therapy (WET) to a course of repeated IV ketamine infusions in improving PTSD symptoms and maintaining symptom improvement in patients with chronic PTSD. WET is a brief, 5-session evidence-based written trauma-focused therapy without in between-session assignments, with demonstrated efficacy and low dropout rates in patients with PTSD. WET will be administered to all eligible participants; the first WET sessions will... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/27/2024
Locations: Depression and Anxiety Center, Icahn School of Medicine at Mount Sinai, Manhattan, New York
Conditions: PTSD
Register for Updates