Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD
NCT04889664
Completed
The current pilot project will evaluate the efficacy of adding Written Exposure Therapy (WET) to a course of repeated IV ketamine infusions in improving PTSD symptoms and maintaining symptom improvement in patients with chronic PTSD. WET is a brief, 5-session evidence-based written trauma-focused therapy without in between-session assignments, with demonstrated efficacy and low dropout rates in patients with PTSD. WET will be administered to all eligible participants; the first WET sessions will... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/27/2024
Locations: Depression and Anxiety Center, Icahn School of Medicine at Mount Sinai, Manhattan, New York
Conditions: PTSD
Register for Updates
Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty
NCT04437888
Completed
Prospective randomized double blinded, placebo controlled study that will evaluate the effect of intra-operative ketamine administration on post-operative analgesic requirements and self-reported pain in patients undergoing total hip and total knee arthroplasty who demonstrate high levels of pain catastrophizing.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: Dartmouth-Hitchcock, Lebanon, New Hampshire
Conditions: Pain, Postoperative, Arthroplasty Complications
Register for Updates
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
NCT06085937
Recruiting
There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/25/2024
Locations: University of Kansas Strawberry Hill Campus, Kansas City, Kansas +1 locations
Conditions: Suicide, Suicidal Ideation, Depression
Register for Updates
Understanding Ketamine's Dissociative Effects (KD Study)
NCT04861051
Recruiting
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Epilepsy
Register for Updates
HNC: Human Neural Circuits Electrophysiology During Cognition
NCT05962424
Recruiting
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: Stanford University, Palo Alto, California
Conditions: Psychiatric Disorder
Register for Updates
Brain Network Dynamics of Depression During Esketamine Treatment
NCT06012916
Completed
This is a monocentric, observational clinical trial investigating the effect of Esketamine on brain network activity and a belief updating task in people with depression. We investigate the immediate and the long-term effect (approx. 8 weeks) of Esketamine on EEG signals, pupillometry and belief updating and the relation of those effects on depressive symptomatology.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
09/13/2024
Locations: Carolina Center for Neurostimulation, Chapel Hill, North Carolina
Conditions: Depressive Disorder, Major
Register for Updates
Oral Ketamine for Treatment of Vaso-Occlusive Pain
NCT05378555
Recruiting
The purpose of this study is to learn more about the feasibility of oral ketamine for the treatment of painful sickle-cell crises in children and adolescents as a supplement to intravenous (IV) opioids. There is a need for improved non-opioid analgesia for patients experiencing sickle-cell crises in the hospital and prehospital setting, as children and adolescents with sickle cell disease who experience sickle-cell crises often have severe pain that is not well controlled by high dose opioids, l... Read More
Gender:
ALL
Ages:
Between 12 years and 24 years
Trial Updated:
08/30/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Vaso-occlusive Crisis
Register for Updates
KET-RO Plus RO DBT for Treatment Resistant Depression
NCT06138691
Active Not Recruiting
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine combined with RO DBT in young adults with Treatment-Resistant Depression (TRD). In addition, this study will develop and utilize innovative methodological approaches to demonstrate the feasibility of precision medicine with this type of therapy.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/29/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Treatment Resistant Depression
Register for Updates
IM Ketamine vs Midazolam for Suicidal ER Patients
NCT04640636
Active Not Recruiting
Rising US suicide rates and the increased risk of suicide among persons who visit an emergency department (ED) for suicidality make the ED an important site for interventions to prevent suicide. There is no approved treatment for rapid relief of suicidal thoughts although clinical trials, including ours, show relief of suicidal thoughts within hours of treatment with inexpensive, generic, sub-anesthetic ketamine. We propose a clinical trial of intramuscular ketamine in depressed ED patients with... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/27/2024
Locations: Comprehensive Psychiatric Emergency Department of Columbia University Medical Center, New York, New York
Conditions: Depression, Unipolar, Depression, Bipolar, Suicidal Ideation
Register for Updates
Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan
NCT06034821
Enrolling By Invitation
This study is a randomized open-label single-blind non-inferiority comparative effectiveness study of ECT vs. KET for the treatment of Acute Suicidal Depression (ASD).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/26/2024
Locations: University of Arizona, Tucson, Arizona +10 locations
Conditions: Acute Suicidal Depression (ASD)
Register for Updates
Ketamine in Severe Traumatic Brain Injury
NCT06062628
Recruiting
Traumatic brain injury (TBI) accounts for approximately 2.5 million visits to emergency departments in the United States each year. After decades of research, management strategies for severe TBI (sTBI) patients are still evolving. Optimizing intracranial pressure (ICP) and cerebral perfusion pressure (CPP) are paramount in the management of these patients and placement of these monitors is the current standard-of-care. However, monitoring brain oxygenation (PbtO2) with invasive intraparenchymal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Parkland Memorial Hospital, Dallas, Texas
Conditions: Traumatic Brain Injury, Traumatic Encephalopathy
Register for Updates
Glutamatergic Mechanisms: Aim2
NCT05401227
Suspended
This is a randomized, double-blind, and placebo controlled. 120 HV will be randomized to one of three ketamine arms, delivered in a bolus dose over one minute: low (0.086 mg/kg), medium (0.125 mg/kg), and high (0.23 mg/kg). Within each ketamine arm, subjects will be randomized to 4 days of TS-134 20 mg or placebo in a 5:3 ratio (25 TS-134:15 placebo). Following an outpatient Screening Period (up to 31 days), eligible subjects will undergo an up to 5-day inpatient Treatment Period. During the st... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/13/2024
Locations: NYSPI, New York, New York
Conditions: Healthy
Register for Updates