A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine
NCT02611505
Completed
The purpose of this study is to evaluate the pharmacokinetics, safety, and tolerability of intranasally administered esketamine in both participants with varying stages of hepatic impairment and healthy participants.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/31/2025
Locations: Not set, Knoxville, Tennessee
Conditions: Hepatic Impairment, Normal Hepatic Function
Register for Updates
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
NCT06069843
Active Not Recruiting
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown to rapidly improve symptoms in depression. Even a single dose of ketamine has been shown to improve depression and cognition with short-term memory, inhibitory control, cognitive flexibility, and processing speed showing improvements within days of treatment. The mechanism behind ketamine's rapid action is not clear but some groups have speculated it may be related to enhanced neuroplasticity, particularly... Read More
Gender:
ALL
Ages:
Between 50 years and 90 years
Trial Updated:
01/27/2025
Locations: Icahn School of Medicine at Mount Sinai (Depression and Anxiety Center), New York, New York
Conditions: Depression, Mild Cognitive Impairment
Register for Updates
The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series
NCT06048263
Not Yet Recruiting
The goal of this open label case series is to learn about the feasibility of conducting a future randomised controlled trial to evaluate how well the Perinatal SMILES intervention works in improving post-cesarean mood in low-income women. The main questions it aims to answer are: 1. Is it feasible to recruit a sufficient number of participants? 2. Is it feasible to administer Perinatal SMILES and 3. Is it feasible to collect participant outcomes? To profile EEG in participants at rest and in... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
01/14/2025
Locations: Barnes-Jewish Hospital, Saint Louis, Missouri
Conditions: Postpartum Depression
Register for Updates
The Impact of Perioperative Ketamine Infusion on Surgical Recovery
NCT04625283
Completed
In order to effectively treat surgical pain with the least amount of opioids required, a multi-modal approach must include medications with different mechanisms of actions at alternative receptors. In light of the opioid epidemic, medical providers at Vanderbilt University Medical Center (VUMC) are strategically combining these medications in a bundled pain-regimen after surgery. These regimens have been shown to decrease opioid consumption, improve surgical outcomes, and reduce hospital stays,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/10/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Opioid Use, Enhanced Recovery After Surgery, Anesthesia, Ketamine, Pain, Postoperative
Register for Updates
Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
NCT05907213
Completed
The purpose of this study is to identify a tolerable dose for postpartum ketamine infusion using a maximum tolerated dose (MTD) 3+3 design. A loading dose over 1 hour will be the MTD variable to be tested, as our data suggest that ketamine side effects occur with the loading dose. The investigators hypothesize that subanesthetic ketamine dose will be well tolerated and any noted side effects will be rated acceptable by postpartum women following cesarean delivery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania
Conditions: Pain, Postoperative, Depression, Postpartum
Register for Updates
Ketamine for Multiple Sclerosis Fatigue
NCT05378100
Recruiting
The proposed study is a single-center, phase II, randomized, double-blind, parallel-group, active-placebo-controlled trial of intravenous low-dose ketamine in patients with MS fatigue.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/08/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Multiple Sclerosis Fatigue
Register for Updates
Ketamine for the Treatment for Alcohol Use Disorder in the ED
NCT05661669
Withdrawn
The investigators' approach is to conduct a pilot double-blind, placebo-controlled randomized clinical trial with individuals with alcohol use disorder (AUD) seeking inpatient alcohol detoxification in the emergency department (ED) to receive either intravenous ketamine or saline placebo. The primary aim is to evaluate the intervention's safety. The secondary aim is to evaluate the preliminary efficacy of alcohol-related outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Brigham and Women's Faulkner Hospital, Boston, Massachusetts
Conditions: Alcohol Use Disorder
Register for Updates
Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting
NCT06752759
Recruiting
This is a double blind active placebo controlled clinical trial for individuals within an inpatient setting with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
12/23/2024
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Severe Depression, Moderate Depression, Ketamine, Midazolam, Peripheral Nervous System Agents, Central Nervous System Agents, Neurotransmitter Agents, Physiologic Effects of Drugs, Sensory System Agents, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Depressive Symptom, Hypnotics and Sedatives, Anti-anxiety Agents, Tranquilizing Agents, Psychotropic Drugs, Anesthetics Agent, GABA Modulators, GABA Agents
Register for Updates
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
NCT05786066
Recruiting
The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid receptors (AMPAR).
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
12/19/2024
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: Depressive Disorder, Major Depressive Disorder, Bipolar Disorder, Post Traumatic Stress Disorder, Suicidal Ideation
Register for Updates
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
NCT05940324
Recruiting
The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/17/2024
Locations: Department of Psychiatry & Behavioral Sciences, Stanford, California
Conditions: Obsessive-Compulsive Disorder
Register for Updates
Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine
NCT04613453
Terminated
The purpose of this study is to determine if intravenous ketamine reduces suicidal thinking compared to an active placebo (midazolam) in adolescents who have treatment resistant depression and a recent history of a suicide event (defined as a suicide attempt, emergency room evaluation for suicidal thinking, or a transition to inpatient care for suicidality in the past 120 days). The primary objective of this study is to determine whether ketamine reduces suicidal ideation (as measured via the C... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
12/16/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Adolescent Suicide, Adolescent Depression
Register for Updates
Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
NCT03470675
Active Not Recruiting
Obstetric anal sphincter injuries (OASIS) encompass both third and fourth degree perineal tears. These tears can have a significant impact on women's quality of life in the short and long term. One of the most distressing immediate complications of this severe perineal injury is perineal pain. Women can also experience postpartum depression, dyspareunia, and altered sexual function after OASIS. This is a randomized controlled trial to study the effects of three interventions (placebo, low dose... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Pain, Postpartum Depression
Register for Updates