Ketamine for Pain in the Emergency Department
NCT03896230
Terminated
This study will prospectively compare the mean Numerical Rating Scale (NRS) pain score reduction amongst three recommended dosing strategies of intravenous ketamine (0.1 mg/kg, 0.2 mg/kg, and 0.3mg/kg) for acute pain in the emergency department (ED).This study will also examine the frequency of adverse events secondary to ketamine including fatigue, dizziness, nausea, headache, feeling of unreality, changes in hearing or vision, mood changes, generalized discomfort, and hallucinations, changes i... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
05/11/2023
Locations: Hackensack University Medical Center, Hackensack, New Jersey
Conditions: Acute Pain
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Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy
NCT04831736
Completed
This is a randomized, single blinded, placebo-controlled trial to study the effectiveness of a subanesthetic dose (0.6mg/kg) of ketamine versus placebo (saline) on postoperative pain on adult women undergoing mastectomy. The objective of the study is to examine the effect of a subanesthetic dose (0.6mg/kg) of ketamine vs. saline control on postoperative pain in subjects who have undergone mastectomy.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
04/24/2023
Locations: NYU Langone Health, New York, New York
Conditions: Postoperative Pain
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Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients
NCT02989597
Terminated
Methadone has several advantages over standard narcotic medications, especially when considering use after a typically painful surgery such as lumbar fusion. Methadone is low cost, has a long half-life, has a convenient dosing schedule, has excellent oral bioavailability, and demonstrates slow onset to withdrawal. The literature comparing methadone to more commonly used post-operative narcotics demonstrates that it manages pain better, sustains consistent plasma concentrations, decreases overall... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/24/2023
Locations: Montefiore Medical Center, Bronx, New York
Conditions: Pain, Postoperative
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Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department Patients
NCT03043430
Terminated
Investigators plan to conduct a randomized, double-blinded, controlled study among pediatric patients requiring minor procedures in the Emergency Department setting. Patients will be randomized to one of two arms of intranasal treatments: ketamine 1.0 mg/kg (K) or midazolam 0.3 mg/kg (M). The primary outcome will be change in anxiety using the Modified Yale Preoperative Anxiety Scale (mYPAS).
Gender:
ALL
Ages:
Between 2 years and 12 years
Trial Updated:
04/23/2023
Locations: San Antonio Military Medical Center, Fort Sam Houston, Texas
Conditions: Anxiety, Pediatric ALL, Procedural Anxiety
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Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
NCT03781817
Terminated
This a randomized clinical trial involving children with non-operative fractures presenting the emergency department randomized either to intranasal or intravenous ketamine.
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
04/19/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Trauma, Fractures, Closed, Children, Only, Deep Sedation, Ketamine
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UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study
NCT03284307
Completed
This study will be a single-site, controlled, unblinded study at the University of Wisconsin to examine changes in the electroencephalogram during anesthesia and waking.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/10/2023
Locations: UW Hospital and Clinics, Madison, Wisconsin
Conditions: Unconsciousness, Consciousness
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Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy
NCT03889756
Terminated
The purpose of this study is to evaluate the intermediate-term efficacy and tolerability of a multiple-dosing ketamine infusion paradigm for the treatment of medication-refractory major depressive disorder (MDD). We are using a two-phase design. The first phase is a 3-week double blind parallel design clinical trial comparing 6 infusions of ketamine compared to 6 infusions of midazolam in 24 adolescents with treatment resistant depression. The primary outcome of this phase will be Children's Dep... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/31/2023
Locations: Yale Child Study Center, New Haven, Connecticut
Conditions: Major Depressive Disorder
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Ketamine for Acute Pain Management After Trauma
NCT04129086
Completed
The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
03/30/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Trauma Injury, Pain, Opioid Use
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Combined Ketamine/Propofol for Emergency Department Procedural Sedation
NCT01126957
Terminated
Introduction Numerous drugs and combinations of drugs are used for procedural sedation and analgesia (PSA) in Emergency Departments, including propofol, ketamine, benzodiazepines, narcotics, barbiturates, and others, but propofol has gained popularity despite its potential to cause cardiac and respiratory depression. Obviously the optimal agent or combination of agents has not been identified. There are reasons to believe that a combination of ketamine and propofol may have advantages over othe... Read More
Gender:
ALL
Ages:
1 year and above
Trial Updated:
03/29/2023
Locations: University of Missouri - Columbia dept. of Emergency Medicine, Columbia, Missouri
Conditions: Procedural Sedation and Analgesia
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The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
NCT01969227
Completed
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements. The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and e... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Mechanical Ventilation, Airway Patency, Respiratory Depression
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Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
NCT01881763
Completed
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients. The investigators hypothesize that patients who receive ketamine anesthesia during ECT will achieve remission status faster than those receiving methohexital anesthesia. Also, at the end of the ECT course subjects will display fewer cognitive side effects compared to those treated with methohexital anesthesia.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/08/2023
Locations: Zucker Hillside Hospital, Glen Oaks, New York
Conditions: Unipolar Depression, Bipolar Depression
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Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
NCT03539887
Completed
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar Disorder (BD) with or without comorbid recent abuse of alcohol.
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
02/27/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Suicidal Ideation, Depression, Alcohol Abuse
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