Ketamine to Prevent PPD After Cesarean
NCT04227704
Completed
The investigators plan to randomise participants to receive ketamine or placebo control subcutaneously or by 40-minute intravenous infusions and will follow them up for 42 days to assess the incidence of postpartum depression. This feasibility pilot study is designed to explore the adequacy of the study procedures and tolerability of the interventions.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
01/06/2023
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Postpartum Depression
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A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)
NCT05133518
Completed
The primary purpose of the study is to evaluate the efficacy and safety of MELT-300 (Midazolam and Ketamine Sublingual Tablets) and the contribution of midazolam and ketamine components to sedation and during the surgery or ocular analgesia in participants undergoing cataract surgery with lens replacement.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
12/15/2022
Locations: Martel Eye Medical Group, Rancho Cordova, California +2 locations
Conditions: Cataract
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Ketamine to Improve Recovery After Cesarean Delivery - Part 1
NCT04037085
Completed
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic modality to reduce pain and opioid requirements. In Part 1, physiochemical analysis of pharmacokinetic/pharmacodynamic (PK/PD) and breastmilk transfer of ketamine and its metabolites will be assessed. Additionally calculated estimations for neonatal and infant exposure will... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
11/23/2022
Locations: UPMC Montefiore Hospital CTRC, Pittsburgh, Pennsylvania +1 locations
Conditions: Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute, Pain, Chronic, Obstetric Anesthesia Problems, Drug Effect, Opioid Use
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Modified Ketogenic Diet and Ketamine for Anorexia Nervosa
NCT04714541
Completed
This Open-Label Pilot Study Aims to Determine Whether a Two-Part Sequenced Out Patient Procedure Utilizing a Modified Ketogenic Diet Followed by a Series of Titrated Ketamine Infusions Results in Improvement or Remission of Chronic Anorexia Nervosa in Adults with Symptoms of Anorexia for at Least 3 Years Despite Treatment Involving at Least 2 Different Modalities. The Hypothesis is That the Diet Addresses Core Metabolic Deficits in the "Anorexic Brain" and Primes the Response to Ketamine.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/01/2022
Locations: Lori Calabrese MD Innovative Psychiatry, South Windsor, Connecticut
Conditions: Anorexia Nervosa
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Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy
NCT02727998
Terminated
The purpose of this study is to combine a single infusion of Ketamine with 7-days of trauma focus psychotherapy to relieve post traumatic stress disorder (PTSD) symptoms more effectively. This treatment has the potential to produce a significant therapeutic effect that otherwise would take months to occur.
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
10/12/2022
Locations: Yale University School of Medicine, New Haven, Connecticut
Conditions: Posttraumatic Stress Disorder
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Acute Pain Management in Patients on Opioid Replacement Therapy
NCT03933865
Terminated
This is an outpatient randomized within subject placebo-controlled human laboratory investigation of analgesia (as assessed with quantitative sensory testing; QST) from ketamine alone and in combination with hydromorphone in buprenorphine maintained participants. The goals of this project are to characterize the analgesic, subjective, and physiologic effects of ketamine combined with hydromorphone in patients on buprenorphine maintenance for opioid use disorder.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/06/2022
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Opioid-use Disorder, Pain, Acute
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The Effects of Sedatives on Tobacco Use Disorder
NCT03813121
Completed
This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/28/2022
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Tobacco Use Disorder
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Ketamine and Epigenetic Aging
NCT05294835
Unknown
This is a prospective, clinical pilot study (n=20) to evaluate the impact of a ketamine treatment for Major Depressive Disorder (MDD) or Post Traumatic Stress Disorder (PTSD) on epigenetic aging by the TruAge epigenetic age laboratory test.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/07/2022
Locations: Wild Health, Lexington, Kentucky
Conditions: Depression, Post Traumatic Stress Disorder
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Low Dose Ketamine for Management of Acute Severe Pain in the Emergency Department
NCT01740492
Completed
This study aims to address both the management and evaluation of pain. The primary aim of this study is to determine the efficacy of low dose ketamine in adults with moderate to severe pain in the emergency department as compared with parenteral opioids alone. Another aim is to examine the safety of low dose ketamine compared to opioids alone. The investigators hypothesize that low dose ketamine will result in more effective pain control than morphine alone and will not be associated with an in... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/06/2022
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Pain
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Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy
NCT04939987
Withdrawn
This study will address the gaps in research of non-opioid postoperative pain management for prostatectomies.
Gender:
MALE
Ages:
Between 40 years and 75 years
Trial Updated:
08/31/2022
Locations: Wake Forest Health Sciences, Winston-Salem, North Carolina
Conditions: Radical Prostatectomies
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Sub-dissociative Dose Ketamine Dosing Study
NCT03714620
Completed
Goal is to determine if in adults presenting to the Emergency Department (ED) with moderate to severe acute pain, Ketamine administered at 0.15 mg/kg will provide similar pain relief to Ketamine administered at 0.3 mg/kg, with fewer adverse effects.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
08/08/2022
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Acute Pain
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miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
NCT02418195
Completed
The purpose of this study is to examine whether neural-derived exosomal miRNAs are differentially expressed that are specific to suicidal ideation or behavior, and which by affecting specific miRNA targets and pathways, are associated with suicidal behavior and response to ketamine. The following groups of subjects will be examined: 1) major depressive disorder (MDD) with a recent suicide attempt (in past 2 weeks), 2) MDD with serious ideation (in the past 7 days) without recent suicide attempt... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/03/2022
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Major Depressive Disorder
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