Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash
NCT01566448
Completed
Oral mucositis (inflammation of the lining of the mouth) is a very common adverse effect when chemotherapy and radiation therapy are used to treat cancer. Mucositis occurs in about 40% of patients receiving standard dose chemotherapy, 80% of patients receiving radiation therapy of the head and neck, and up to 100% of patients undergoing a bone marrow transplant. Because the pain from mucositis can be so bad it can cause the inability to eat or drink, inability to talk, gagging and drooling. Many... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2022
Locations: West Virginia University Hospitals Mary Babb Randolph Cancer Center, Morgantown, West Virginia
Conditions: Mucositis
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Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures
NCT04061330
Withdrawn
The purpose of this study is to establish the feasibility of initiating a ketamine pain control protocol in the emergency department for the treatment of acute pain in patients with long bone fractures and to compare the efficacy of the ketamine pain protocol to bolus morphine for pain control in the first 6 hours of patient stay in the emergency department.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/19/2022
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Pain, Acute
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Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects
NCT04173962
Completed
The objective of this study is to examine the effect of a single IV dose of ketamine (0.5 mg/kg) on laboratory-induced stress in healthy participants.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
04/18/2022
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Healthy Volunteers
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Intramuscular Ketamine for Suicidal Ideation
NCT05105061
Withdrawn
The objective of the present research protocol, a cross-over, subject-blinded, clinical trial, is to correlate changes in brain activity with reduction in suicidal ideation in response to a single intramuscular dose of ketamine. While ketamine is increasingly used as a rapid, antidepressant agent, there is accumulating evidence of additional anti-suicidal properties that may be distinct from its effects on depression. This pilot study will be used to determine (1) whether specific electroencepha... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/24/2022
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Suicidal Ideation
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Ketamine Versus Fentanyl for Surgical Abortions
NCT04871425
Completed
Ketamine is commonly used for procedural sedation and analgesia. It is widely used for trauma cases in the emergency department and is considered a superior agent in the outpatient setting due to its lack of respiratory and cardiovascular depression. In chronic opioid users, ketamine decreases acute pain and reduces postoperative opioid consumption. Few studies have examined the use of ketamine for surgical abortions. Previous studies found significant rates of emergence phenomena; however, this... Read More
Gender:
FEMALE
Ages:
14 years and above
Trial Updated:
03/22/2022
Locations: Cedar River Clinic, Renton, Washington
Conditions: Abortion in First Trimester, Pain, Procedural, Opioid Use
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Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects
NCT00700076
Completed
Org 25935 is a new putative antipsychotic agent developed by N.V. Organon.The primary objective of this study is to investigate the effect of Org 25935 on ketamine-induced impairments in immediate recall.
Gender:
MALE
Ages:
Between 18 years and 55 years
Trial Updated:
03/02/2022
Locations: Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine, West Haven, Connecticut
Conditions: Healthy
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The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.
NCT03156504
Completed
The purpose of this research study is to find out if the medication known as ketamine can help the symptoms of depression. This drug is approved by the Food and Drug Administration (FDA) but the investigators will use it for a non-FDA approved reason (depression).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/23/2022
Locations: Johns Hopkins Hospital, Baltimore, Maryland +3 locations
Conditions: Major Depression, Bipolar I Disorder, Bipolar II Disorder, Unipolar Depression
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Ketamine in Veterans With Gulf War Illness
NCT04712071
Terminated
Up to one third of the 700,000 U.S. military veterans of the 1990-91 Gulf War have Gulf War Illness (GWI), a symptom complex characterized by a combination of chronic pain, cognitive impairment, debilitating fatigue, gastrointestinal complications, and other persistent symptoms. Epidemiologic studies of 1990-1991 Gulf War veterans have identified the short but intense combined exposure to insecticides (e.g., organophosphates, DEET, permethrin), pills with anti-nerve gas agent pyridostigmine brom... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/16/2022
Locations: Marijn Lijffijt, Houston, Texas
Conditions: Gulf War Syndrome
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Effect of Ketamine on Postoperative Clinical Outcomes
NCT01365195
Terminated
The purpose of this research is to evaluate the effectiveness of ketamine as an analgesic adjuvant in decreasing the narcotic (opioids) analgesics during surgery, on pain management and on the later recovery after surgery in patients undergoing colorectal surgery.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/09/2022
Locations: Cedars Sinai Medical center, Los Angeles, California
Conditions: Colorectal Surgery
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Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder
NCT05209217
Unknown
Aim 1: Test the hypothesis that participants with Bipolar Disorder - Fear of Harm Phenotype have an enhanced amygdala fMRI response to fearful threatening stimuli, increased resting beta and gamma EEG spectral activity in temporal leads and blunted posterior insula response to cold when partially withdrawn from ketamine with normalization of these responses following intranasal administration of ketamine. Aim 2. Test the hypothesis that ketamine alters response to fearful-threatening visual sti... Read More
Gender:
ALL
Ages:
Between 14 years and 40 years
Trial Updated:
01/26/2022
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Bipolar Disorder
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The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
NCT02554253
Completed
Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. It has been shown to have anti-inflammatory properties which may decrease post-operative complications following cardiac surgery with cardiopulmonary bypass that are thought to associated with inflammation. Some studies have shown that ketamine does decrease these complications when compared with anesthetics that are not commonly used in our cardiac anesthesiology practice. Pro... Read More
Gender:
ALL
Ages:
75 years and above
Trial Updated:
01/24/2022
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cognitive Disorders, Delirium, Acute Kidney Injury
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A Study to Assess the Electrophysiology, Safety, Tolerability, and Pharmacokinetics of SAGE-718 Using a Ketamine Challenge in Healthy Subjects
NCT03771586
Completed
This study is a phase 1, double-blind, placebo-controlled crossover study of single, oral dose of SAGE-718 using a ketamine challenge, to evaluate the electrophysiology, safety, tolerability, and pharmacokinetics in healthy subjects
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2022
Locations: Sage Investigational Site, Long Beach, California +1 locations
Conditions: Healthy Volunteer
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