The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women
NCT04285684
Completed
Quantification of Ketamine in Breast Milk at 3 hour Intervals up to 30 hours-- obtained from lactating women who receive 2 different Intramuscular injections of ketamine on two separate days at least 5 days apart.
Gender:
FEMALE
Ages:
Between 21 years and 45 years
Trial Updated:
12/10/2021
Locations: Ketamine Research Foundation, San Anselmo, California
Conditions: Ketamine, Lactation
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Methadone and Ketamine for Spinal Surgery
NCT02827526
Completed
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure. Several factors contribute to postoperative pain in this patient population. Many patients present to surgery dependent on relatively high doses of oral opioids; this daily administration leads to tolerance to the effects of these drugs as well as hyperalgesia (exposure to opioids makes subsequent pain worse). In addition, surgical procedures on the... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/06/2021
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Pain
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Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial
NCT02643381
Completed
Patients who are having problems breathing sometimes require placement of a breathing tube in their mouth and windpipe. The purpose of this breathing tube is to save the patient's life. It is common to give the patient a medication to sedate him or her before the breathing tube is placed. For patients who are gravely ill two medications are commonly used: etomidate or ketamine. Both medications have risks and benefits. Researchers at UT-Southwestern Medical Center and Parkland Memorial Hospital... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2021
Locations: Parkland Hospital, Dallas, Texas
Conditions: Cardiopulmonary Arrest, Respiratory Arrest
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Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine
NCT03621085
Completed
The purpose of this project is to test how ketamine, an analgesics currently employed in the pre-hospital setting by the US Army, alters the capacity to tolerate a hemorrhagic insult in humans.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
10/29/2021
Locations: Texas Health Presbyterian Hospital Dallas, Dallas, Texas
Conditions: Hemorrhage, Healthy
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Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation
NCT03545503
Completed
The purpose of this study is to compare the hemodynamic effects of ketamine v etomidate during rapid sequence intubation (RSI) in the pre-hospital and emergency department setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2021
Locations: New Hanover Regional Medical Center, Wilmington, North Carolina
Conditions: Intubation Complication
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Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression
NCT03756129
Completed
This study evaluated the efficacy and safety of the compound MIJ821 compared to placebo in patients aged from 18 to 65 years diagnosed with treatment-resistant depression. The study was conducted in the US and in Europe (Spain). The MIJ821 was administered via infusion on a weekly or bi-weekly basis. The efficacy was measured after 24 hours using a specific golden standard scale, the Montgomery-Asberg Depression Rating Scale. The study duration was 6 weeks of treatment plus 1 month of follow up... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/07/2021
Locations: Novartis Investigative Site, Birmingham, Alabama +11 locations
Conditions: Depressive Disorder, Treatment-Resistant
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Bubiket Study: Ultrasound Guided Fascia Iliaca Nerve Block With Bupivacaine and Adjuvant Ketamine vs. Bupivacaine Alone
NCT03909594
Withdrawn
The project is meant to evaluate the effect of a combination of medications (Bupivacaine + Ketamine) used in an ultra-sound guided nerve block for patients presenting to the Emergency Department (ED) with hip and/or femur fractures. The goal is to see whether the combination of these two medications will result in greater and longer-lasting pain relief, longer-lasting motor and sensory block and overall less need for opioid rescue analgesia.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
10/04/2021
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain, Musculoskeletal
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Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression
NCT04011592
Terminated
Postpartum depression is a non-psychotic major or minor depressive episode that occurs during pregnancy or within 12 months of post-partum period. The nature of symptoms is same as depressive episode characterized by depressed mood, anxiety, sleep difficulties, suicidal thoughts, tiredness and diminished interest in pleasurable activities. Severe maternal depression affects children by increasing the risk of emotional and behavioral and physical health problems and cognitive difficulties. Thus e... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
09/29/2021
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Post Partum Depression
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Pharmacokinetics of Antiepileptics in Patients on CRRT
NCT03632915
Completed
The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/27/2021
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Acute Kidney Injury, Renal Insufficiency, Renal Failure, Pharmacokinetics
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Ketamine/Placebo Family History Positive Study
NCT00588952
Completed
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism. This study may lead to an enhanced understanding of the underlying neurobiological mechanism in high-risk individuals that may lead to the transition from moderate to excessive use of alcohol.
Gender:
ALL
Ages:
Between 21 years and 30 years
Trial Updated:
09/09/2021
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: Alcoholism
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Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
NCT02037035
Completed
This study is looking at the mechanisms underlying the behavioral effects of ketamine in healthy and depressed individuals.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
09/07/2021
Locations: Yale Depression Research Program, New Haven, Connecticut
Conditions: Depression
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Intranasal (NAS) Ketamine for Cancer Pain
NCT03146806
Completed
The main purpose of this study is to determine the safety, feasibility, and utility of intranasal (NAS) ketamine in persistent uncontrolled cancer related pain. In this prospective clinical trial the researchers will investigate the use of NAS ketamine in patients with pain related to cancer or cancer treatment. The researchers plan to enroll at least 25 patients meeting inclusion/exclusion criteria, to achieve a minimum of 10 patients who complete the study. Participants will be recruited from... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2021
Locations: Winship Cancer Institute, Atlanta, Georgia
Conditions: Cancer, Pain
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