Acute Pain Management in Patients on Opioid Replacement Therapy
NCT03933865
Terminated
This is an outpatient randomized within subject placebo-controlled human laboratory investigation of analgesia (as assessed with quantitative sensory testing; QST) from ketamine alone and in combination with hydromorphone in buprenorphine maintained participants. The goals of this project are to characterize the analgesic, subjective, and physiologic effects of ketamine combined with hydromorphone in patients on buprenorphine maintenance for opioid use disorder.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/06/2022
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Opioid-use Disorder, Pain, Acute
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The Effects of Sedatives on Tobacco Use Disorder
NCT03813121
Completed
This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/28/2022
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Tobacco Use Disorder
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Ketamine and Epigenetic Aging
NCT05294835
Unknown
This is a prospective, clinical pilot study (n=20) to evaluate the impact of a ketamine treatment for Major Depressive Disorder (MDD) or Post Traumatic Stress Disorder (PTSD) on epigenetic aging by the TruAge epigenetic age laboratory test.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
09/07/2022
Locations: Wild Health, Lexington, Kentucky
Conditions: Depression, Post Traumatic Stress Disorder
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Low Dose Ketamine for Management of Acute Severe Pain in the Emergency Department
NCT01740492
Completed
This study aims to address both the management and evaluation of pain. The primary aim of this study is to determine the efficacy of low dose ketamine in adults with moderate to severe pain in the emergency department as compared with parenteral opioids alone. Another aim is to examine the safety of low dose ketamine compared to opioids alone. The investigators hypothesize that low dose ketamine will result in more effective pain control than morphine alone and will not be associated with an in... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/06/2022
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Pain
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Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy
NCT04939987
Withdrawn
This study will address the gaps in research of non-opioid postoperative pain management for prostatectomies.
Gender:
MALE
Ages:
Between 40 years and 75 years
Trial Updated:
08/31/2022
Locations: Wake Forest Health Sciences, Winston-Salem, North Carolina
Conditions: Radical Prostatectomies
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Sub-dissociative Dose Ketamine Dosing Study
NCT03714620
Completed
Goal is to determine if in adults presenting to the Emergency Department (ED) with moderate to severe acute pain, Ketamine administered at 0.15 mg/kg will provide similar pain relief to Ketamine administered at 0.3 mg/kg, with fewer adverse effects.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
08/08/2022
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Acute Pain
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miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
NCT02418195
Completed
The purpose of this study is to examine whether neural-derived exosomal miRNAs are differentially expressed that are specific to suicidal ideation or behavior, and which by affecting specific miRNA targets and pathways, are associated with suicidal behavior and response to ketamine. The following groups of subjects will be examined: 1) major depressive disorder (MDD) with a recent suicide attempt (in past 2 weeks), 2) MDD with serious ideation (in the past 7 days) without recent suicide attempt... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/03/2022
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Major Depressive Disorder
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IN Sub-Dissociative Ketamine vs IN Fentanyl
NCT02521415
Completed
This single center, randomized control, double blind trial will prospectively examine the feasibility of intranasal, sub-dissociative (IN) ketamine versus intranasal fentanyl for pain control in the pediatric emergency department setting. The investigators hypothesize that IN ketamine may provide a safe and effective alternative to IN fentanyl for children with suspected, isolated extremity fractures. Eighty children ages 3-17 years with a suspected, isolated extremity fracture that requires an... Read More
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
06/30/2022
Locations: Carolinas Medical Center Main - Levine Children's Hospital Emergency Department, Charlotte, North Carolina
Conditions: Bone Fracture
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Nebulized Sub-dissociative Dose Ketamine for Treating Pain
NCT03909607
Completed
The investigators previous research study comparing the efficacy of intravenous ketamine to morphine showed ketamine to provide equivalent relief of moderate to severe acute pain in emergency department patients. A second study by the investigators showed that increasing the time of administration of the ketamine, from a push injection to a drip infusion, will minimize the adverse effects experienced by recipients of ketamine. The investigators now aim to see if nebulized subdissociative-dose k... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
05/26/2022
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain
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Ketamine and Magnesium in Post-operative Pain Control in Patients Treated With Opioids
NCT02940509
Terminated
The goal of this research proposal is to determine if the intraoperative administrative of Ketamine and Magnesium during laparoscopic gynecologic surgery improves postoperative pain in patients on chronic opioid therapy for management of chronic pelvic pain.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
05/24/2022
Locations: Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Chronic Pain
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CAP-Ketamine for Antidepressant Resistant PTSD
NCT02655692
Completed
The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as compared to placebo, in reducing symptoms of Posttraumatic Stress Disorder (PTSD) in an active duty military and Veteran population.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/06/2022
Locations: VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut +2 locations
Conditions: PTSD, Posttraumatic Stress Disorder
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Use of Transmucosal Ketamine in Post Stroke Depression
NCT04876066
Unknown
Studies have shown that ketamine is very effective and has a quick onset in treatment of depression. Most of these studies used intravenous ketamine in an inpatient setting and there are no large trials examining its use in Post Stroke Depression (PSD). There have been only few studies that have used other routes of administration (i.e., oral, transmucosal, intranasal, intramuscular) of ketamine which provided symptom relief for depression. The purpose of this study is to assess the effectivenes... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2022
Locations: WVU Medicine, Morgantown, West Virginia
Conditions: Post-stroke Depression
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