Ketamine and Prolonged Exposure in PTSD
NCT03960658
Completed
This study aims at investigating the effectiveness of the drug, Ketamine, in combination with Prolonged Exposure (PE) therapy for people suffering from PTSD. Participation in the study includes Ketamine infusions, which occur once a week for three weeks. PE therapy sessions will be scheduled one day after each infusion, and may continue up to 12 weeks. After completely therapy, there will be two monthly follow-up assessment visits.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/19/2021
Locations: Minneapolis VA Medical Center, Minneapolis, Minnesota
Conditions: Post-traumatic Stress Disorder
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Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic Pain
NCT02920528
Completed
This is a prospective, randomized controlled trial which will be conducted to determine whether sub-dissociative dose ketamine (SDDK) can improve pain control in subjects with chronic pain syndrome presenting to the emergency department with exacerbation of their chronic pain. The investigators also aim to determine whether use of SDDK can reduce the amount of subsequent opioid pain medications required for adequate pain relief in this population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2021
Locations: Emergency Department, Harbor-UCLA Medical Center, Torrance, California
Conditions: Chronic Pain
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Ketamine for Acute Migraine in the Emergency Department
NCT02697071
Completed
This research study will be a prospective, randomized, double-blind, placebo-controlled trial. Because ketamine has yet to be directly studied as treatment for acute migraine headache in the emergency department, the research team is initially interested if ketamine can reduce pain scores in headache patients and reduce the incidence of recurrence while exhibiting an adequate safety profile. By using a placebo-controlled study design, the research team can adequately investigate the effectivenes... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/02/2021
Locations: Carilion Roanoke Memorial Emergency Department, Roanoke, Virginia
Conditions: Headache
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Ketamine for Mood Disorders With Suicidal Ideation
NCT04099771
Unknown
This study will explore whether the use of a medication, Ketamine, can help patients who come to the ER with thoughts of suicide by improving their mood and reducing thoughts of suicide. Ketamine has been used for this purpose in patients who have been hospitalized, but it has not been well studied in the ER. The investigators are first trying to show that patients and doctors in the ER find the treatment acceptable. The investigators also hope to determine whether Ketamine is effective in decre... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/01/2021
Locations: The Miriam Hospital, Providence, Rhode Island
Conditions: Depressive Disorder, Major, Suicidal Ideation
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A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery
NCT02341963
Terminated
The purpose of this pilot study is to test the safety of oral ketamine to treat acute pain after amputation surgery. The objective of the proposed research is to conclusively determine if oral ketamine is a safe alternative analgesic to opioid for acute pain in subjects undergoing elective amputation of the lower extremity. All participants will receive oral ketamine.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/24/2021
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Acute Pain Management, Analgesic, Nonopioid, Amputation of Lower Extremity, All Causes
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Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics
NCT03947099
Completed
This is an observational study to assess the change in several psychological screening tools before and after a series of six ketamine infusions in paramedics who suffer from post traumatic stress disorder as a result of working in emergency medical services.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/24/2021
Locations: Klarisana, San Antonio, Texas
Conditions: Stress Disorders, Post-Traumatic, Anxiety Disorders
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Micro-Dose, Macro-Impact: Leveraging Psychedelics in Frontline Healthcare Workers During the COVID-19 Pandemic
NCT04769297
Unknown
A retrospective chart review of an open-label trial of low-dose ketamine administered to front-line Healthcare workers who were identified as experiencing acute stress disorder due to the COVID-19 Pandemic.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/23/2021
Locations: Limbic Medical, Toluca Lake, California
Conditions: Acute Stress Disorder
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Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine
NCT04767035
Completed
A Pivotal Phase 1, Randomized, Single-Dose, 4-Period, Crossover Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine under Fasted Conditions in Healthy Volunteers
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
02/22/2021
Locations: Worldwide Clinical Trials, San Antonio, Texas
Conditions: Procedural Sedation
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Ketamine Infusion for Social Anxiety Disorder
NCT02083926
Completed
* Social Anxiety Disorder (SAD) is common and causes significant impairment. * First-line treatments for Social Anxiety Disorder are only partially effective. Many SAD patients experience little or inadequate symptom relief with available treatments. * Ketamine is a potent NMDA receptor antagonist. Ketamine represents an agent with a potentially novel mechanism of action for the treatment of anxiety disorders. * Ketamine has demonstrated efficacy in the treatment of psychiatric disorders closely... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/22/2021
Locations: Connecticut Mental Health Center, New Haven, Connecticut
Conditions: Social Anxiety Disorder
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Phase 1 Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual) and IV Midazolam or Ketamine
NCT04485702
Completed
Comparative Bioavailability study testing MELT-100 (midazolam and ketamine sublingual tablet) and IV midazolam or ketamine in healthy volunteers
Gender:
ALL
Ages:
55 years and above
Trial Updated:
02/22/2021
Locations: WWCT, San Antonio, Texas
Conditions: Healthy Volunteers
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Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
NCT02397889
Completed
The purpose of this study is to study new ways to treat post-traumatic stress disorder (PTSD). Current treatments for PTSD do not work for everyone and it can take time to determine whether a person responds to a chosen treatment. The purpose of this study is to see whether ketamine, when given repeatedly intravenously can produce a quick and persistent improvement in PTSD symptoms. At higher doses, ketamine has been used for many years as an anesthetic for medical procedures, and at lower doses... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/16/2021
Locations: Depression and Anxiety Center (DAC), New York, New York
Conditions: Posttraumatic Stress Disorder (PTSD)
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Ketamine vs Hydromorphone
NCT03001843
Completed
This study will help to determine if investigators can minimize narcotic use in laparoscopic gastric bypass patients while maintaining adequate pain control. This will allow investigators to minimize the negative side effects of narcotics which is a goal in this population.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/16/2021
Locations: University of Florida, Gainesville, Florida
Conditions: Laparoscopic Gastric Bypass, Obesity, Pain, Postoperative
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