Bubiket Study: Ultrasound Guided Fascia Iliaca Nerve Block With Bupivacaine and Adjuvant Ketamine vs. Bupivacaine Alone
NCT03909594
Withdrawn
The project is meant to evaluate the effect of a combination of medications (Bupivacaine + Ketamine) used in an ultra-sound guided nerve block for patients presenting to the Emergency Department (ED) with hip and/or femur fractures. The goal is to see whether the combination of these two medications will result in greater and longer-lasting pain relief, longer-lasting motor and sensory block and overall less need for opioid rescue analgesia.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
10/04/2021
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain, Musculoskeletal
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Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression
NCT04011592
Terminated
Postpartum depression is a non-psychotic major or minor depressive episode that occurs during pregnancy or within 12 months of post-partum period. The nature of symptoms is same as depressive episode characterized by depressed mood, anxiety, sleep difficulties, suicidal thoughts, tiredness and diminished interest in pleasurable activities. Severe maternal depression affects children by increasing the risk of emotional and behavioral and physical health problems and cognitive difficulties. Thus e... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
09/29/2021
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Post Partum Depression
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Pharmacokinetics of Antiepileptics in Patients on CRRT
NCT03632915
Completed
The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/27/2021
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Acute Kidney Injury, Renal Insufficiency, Renal Failure, Pharmacokinetics
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Ketamine/Placebo Family History Positive Study
NCT00588952
Completed
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism. This study may lead to an enhanced understanding of the underlying neurobiological mechanism in high-risk individuals that may lead to the transition from moderate to excessive use of alcohol.
Gender:
ALL
Ages:
Between 21 years and 30 years
Trial Updated:
09/09/2021
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: Alcoholism
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Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
NCT02037035
Completed
This study is looking at the mechanisms underlying the behavioral effects of ketamine in healthy and depressed individuals.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
09/07/2021
Locations: Yale Depression Research Program, New Haven, Connecticut
Conditions: Depression
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Intranasal (NAS) Ketamine for Cancer Pain
NCT03146806
Completed
The main purpose of this study is to determine the safety, feasibility, and utility of intranasal (NAS) ketamine in persistent uncontrolled cancer related pain. In this prospective clinical trial the researchers will investigate the use of NAS ketamine in patients with pain related to cancer or cancer treatment. The researchers plan to enroll at least 25 patients meeting inclusion/exclusion criteria, to achieve a minimum of 10 patients who complete the study. Participants will be recruited from... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2021
Locations: Winship Cancer Institute, Atlanta, Georgia
Conditions: Cancer, Pain
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IN Ketamine vs IN Midazolam and Fentanyl for Laceration Repair
NCT03528512
Terminated
Often, repair of the cuts (laceration repair) proves to be traumatic for the children and the parents. Nasal spray (Intranasal/IN) approaches for procedural pain reduction, such as during dental work, have been demonstrated to make drug administration painless and well tolerated. We are comparing IN ketamine to IN midazolam and fentanyl for pain and reducing anxiety during repair of cuts in children.
Gender:
ALL
Ages:
Between 6 months and 10 years
Trial Updated:
07/29/2021
Locations: Beaumont Hospital - Royal Oak, Royal Oak, Michigan
Conditions: Laceration of Skin
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Pre-hospital Nebulized Ketamine for Pain
NCT04162028
Withdrawn
In the situation when intravenous access is not readily available or unobtainable, or when prehospital delays to obtain intravenous access are not warranted, sub-dissociative dose ketamine can be administered via intranasal (IN) route. The data supporting IN is not set on the optimum intranasal dose (range 0.75-1 mg/kg) and frequencies of administration. In addition, IN administration of SDK for adult patients in the ED requires a highly concentrated solution that is not routinely stock in the E... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
07/28/2021
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain
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Comparison of Outcomes During MRI Sedation With Midazolam-dexmedetomidine Versus Ketamine-dexmedetomidine
NCT02129426
Terminated
This study will compare 2 different sedation drugs (Ketamine and Midazolam) when they are used with another sedating medicine called Dexmedetomidine for MRI sedation. This study hopes to measure the impact each drug has on what happens during and after MRI sedation with Dexmedetomidine
Gender:
ALL
Ages:
18 years and below
Trial Updated:
07/12/2021
Locations: University of Louisville, Louisville, Kentucky
Conditions: Sedation
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Delirium Prevention With Ketamine in Ear, Nose, and Throat (ENT) Patients
NCT03040024
Terminated
The goal of this prospective randomized double blinded placebo controlled study is to investigate if a single dose of ketamine in addition to standard anesthesia will reduce the risk of delirium in otolaryngeal cancer patients postoperatively. Ketamine's effect on post-operative pain and opioid use will be measured as well. Electroencephalogram (EEG) will be utilized during the surgical procedure to evaluate its potential as a possible predictive device for delirium.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2021
Locations: Emory University Hospital Midtown, Atlanta, Georgia
Conditions: Otolaryngeal Cancer
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Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia
NCT02761330
Completed
This study is geared toward characterizing the recovery of brain activity and cognitive function following treatments of electroconvulsive therapy and ketamine general anesthesia.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/25/2021
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Depression, Delirium, Seizures, Cognitive Disorders
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Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus
NCT03115489
Withdrawn
The study will investigate the efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as a first line agent in refractory status epilepticus versus traditional general anesthetic agents used for burst suppression that target the gamma-aminobutyric acid adrenergic receptors.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/18/2021
Locations: UAB Department of Anesthesiology and Perioperative Medicine, Birmingham, Alabama
Conditions: Refractory Epilepsy
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