Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department
NCT01538745
Completed
The purpose of this study is to compare the safety and effectiveness of intravenous low dose ketamine (LDK) to the industry standard of morphine (MOR) in regards to controlling acute pain in the emergency department. Both LDK and morphine have side effects. The amount and character of these side effects will be compared. Additionally, the degree of sedation or agitation will be specifically measured. The aim of this current study is to make this comparison and shift the evidence for LDK use fro... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
02/03/2021
Locations: Brooke Army Medical Center, San Antonio, Texas
Conditions: Abdomen, Acute, Other Acute Pain, Flank Pain, Back Pain, Musculoskeletal Pain
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The PATHFINDER Study: A Feasibility Trial
NCT04016740
Completed
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery, decrease in postoperative delirium, and decrease in long term postoperative cognitive dysfunction up to 6 months following cardiac surgery.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/27/2021
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Coronary Artery Disease, Delirium
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A Randomized, Double-Masked, Controlled, Single Site Investigator Initiated, Exploratory Study of the Midazolam/Ketamine Melt vs Ketamine Melt Alone vs Midazolam Melt Alone in Subjects Undergoing Intraocular Surgery.
NCT04725747
Unknown
This study is designed to explore the sedative and analgesic effectiveness of the Midazolam/Ketamine melt compared to Midazolam melt alone or Ketamine melt alone in subjects undergoing intraocular surgery.
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
01/22/2021
Locations: Vance Thompson Vision, Sioux Falls, South Dakota
Conditions: Anesthesia
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The Role of HNKs in the Antidepressant Effect of Ketamine
NCT03977675
Terminated
The objective of the proposed study is to examine the relationship between serum concentrations of HNK and changes in the Hamilton Depression Rating Scale (HDRS), Beck Depression Inventory (BDI), and the Profile of Mood States (POMS), as well as glutamatergic/GABAergic response. To achieve these aims the investigators propose a double-blind, uncontrolled (no placebo, no healthy control subjects) study with several different doses of ketamine. The investigators will conduct MRI scans to measure G... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2021
Locations: New York State Psychiatric Institute, New York, New York
Conditions: Major Depressive Disorder
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Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine
NCT04216888
Completed
This pilot study aims to identify predictors of response to intranasal ketamine treatment in patients with treatment-resistant depression. Participants will give a sample of blood and undergo magnetic resonance imaging before and after a single intranasal ketamine treatment. Participants will subsequently receive a second intranasal ketamine treatment.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2021
Locations: Nathan Kline Institute, Orangeburg, New York
Conditions: Depressive Disorder, Treatment-Resistant
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A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients
NCT03714919
Completed
This proposed study will assess analgesic efficacy of a multi-modal, non-opioid analgesic regimen for providing surgical analgesia in pediatric patients undergoing adenoidectomy and to assess recovery characteristics in the post-anesthesia care unit (PACU) and at home following surgery.
Gender:
ALL
Ages:
Between 4 years and 8 years
Trial Updated:
01/19/2021
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Adenoid Hypertrophy
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Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control
NCT04698772
Completed
The proposed research will be a single blinded (patient) randomized controlled prospective trial of adult patients receiving treatment for moderate to severe abdominal pain to test the hypothesis that patient satisfaction with pain control with Ketamine will be comparable to patient satisfaction with pain control using morphine when treating abdominal pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/05/2021
Locations: CHRISTUS, Corpus Christi, Texas
Conditions: Abdominal Pain
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Ketamine Infusion for Comorbid PTSD and Chronic Pain
NCT04322968
Completed
The purpose of the study is to investigate the effectiveness of low dose IV ketamine infusion in the treatment of patients with PTSD and comorbid chronic pain. Hypothesis: A single ketamine infusion should be associated with significantly greater reduction in core PTSD symptom levels after the treatment and such an effect is not only due to its analgesic properties but also through unknown mechanism of action that maybe related to NMDA/AMPA receptor modulation.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/30/2020
Locations: Ann Arbor VA Medical Center, Ann Arbor, Michigan
Conditions: PTSD, Chronic Pain
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The UTHealth Ketamine Project
NCT02882711
Terminated
The primary objective of this study is to determine the effectiveness of serial infusions of intravenous (IV) ketamine in adults with treatment resistant depression (TRD).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/06/2020
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Treatment Resistant Depression, Major Depressive Disorder, Bipolar Disorder
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Anesthetic Techniques in EP Patients
NCT02664922
Terminated
The purpose of this study is to compare different combinations of anesthetic drugs (cause loss of sensation) in terms of effectiveness, adverse effects, pain relief, and patient comfort for cardiac electrophysiology procedures. In addition, the investigators are studying the different anesthetic combinations to determine the best approach in terms of identification and treatment of arrhythmias.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/21/2020
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Cardiac Disease
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Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain
NCT03959852
Terminated
The objective of this study is to evaluate the potential opioid-sparing effect associated with the novel combination of fentanyl and sub-dissociative ketamine in adult patients with moderate to severe pain in the emergency department.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/09/2020
Locations: St. Elizabeth Boardman Hospital, Boardman, Ohio
Conditions: Pain, Acute
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Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department
NCT04266288
Completed
The purpose of this study is to examine the effect of a low-dose ketamine infusion on depression symptoms within the Emergency Department (ED) visit, and healthcare utilization after leaving the ED, when administered in the ED for depression or suicidal ideation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/31/2020
Locations: MercyOne Des Moines Medical Center, Des Moines, Iowa
Conditions: Depression, Depression Severe, Depression Acute, Depression and Suicide, Suicidal Ideation
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