Memory Modulation by Pain During Anesthesia
NCT02515890
Completed
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
06/22/2020
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Amnesia, Pain, Anesthesia
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The Sustained Effects of Ketamine
NCT02708849
Terminated
The purpose of the study is to characterize the effects of a single, sub-anesthetic dose of ketamine in rs-fMRI in healthy subjects. Post-ketamine rs-fMRI data will demonstrate a pattern of increased global brain connectivity (GBC) in fronto-temporal cortex.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/18/2020
Locations: Yale Center for Clinical Investigation, Yale University, New Haven, Connecticut
Conditions: Mental Disorders
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Intravenous Ketamine Effects on Functional Neuroanatomy
NCT04205890
Withdrawn
The purpose of this study is to investigate the neuroanatomical effects of ketamine treatment on patients with treatment-resistant depression. The investigators will compare the neuroimaging of patients several days before and after injection in order to assess the more durable changes induced by ketamine. In addition, changes in perfusion will be analyzed, in addition to changes in neurovascular coupling, and functional connectivity that are correlated with psychiatric measures.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/28/2020
Locations: Neurological Associates of West Los Angeles, Santa Monica, California
Conditions: Depression
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Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial
NCT02105415
Completed
The hypothesis of this study is that a Ketamine / Propofol mixture will produce more stable hemodynamics as compared to Etomidate during emergent intubations in the intensive care unit. Patients that require a breathing tube to be placed in the ICU will be randomized to receIve either a Ketamine / Propofol mixture or Etomidate for sedation in order to place the breathing tube.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/28/2020
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Critical Illness
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The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation.
NCT02997722
Terminated
This study will evaluate the effect of ketamine on the treatment of patients hospitalized with suicidal thoughts. Half of the patients will receive one dose of ketamine in the vein. The other half will receive a placebo. Because we think that ketamine will improve depression and suicidal thoughts, we expect that patients who receive ketamine will require less time in the hospital than patients who receive placebo.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/18/2020
Locations: University of Mississippi Medical Center, Jackson, Mississippi
Conditions: Suicidal Ideation
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Effect of Single Dose Ketamine and Magnesium on Postoperative Pain in Patients Undergoing Bariatric Surgery
NCT02334059
Completed
Opioid sparing analgesia is extremely important in the post-operative obese population. With more and more obese patients entering the operating room a multi-modal approach to analgesia is crucial. Finding effective alternatives to opioid therapy is the rationale of this proposal. Literature involving ketamine and magnesium in bariatric surgical patients is very sparse.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/15/2020
Locations: Milton S.Hershey Medical Center, Hershey, Pennsylvania
Conditions: Obesity
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Low Dose Ketamine Infusion for the Treatment of Resistant Depression
NCT04283058
Withdrawn
The purpose of this investigator-initiated observational study is to examine how low Ketamine infusion treatments impact antidepressant and anti-suicidal effects for refractory and non-refractory depression.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
04/29/2020
Locations: Loma Linda University Medical Center, Loma Linda, California
Conditions: Depression
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Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department
NCT02916927
Completed
Objective: The purpose of this study is to determine if administering ketamine as an intravenous (IV) infusion over 15 minutes, as compared to an IV push, will decrease adverse drug reactions without attenuating its analgesic effects. Study design: prospective, randomized, controlled, double-blind trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2020
Locations: Alameda Health System, Highland Hospital, Oakland, California
Conditions: Pain
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ACL Repair and Multimodal Analgesia
NCT01868425
Completed
This study will evaluate the effectiveness of an aggressive multimodal regimen versus standard multimodal for Anterior Cruciate Ligament (ACL) repair using hamstring graft for patients having surgery in our outpatient surgicenter.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/13/2020
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Pain
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Ketamine in the Treatment of Suicidal Depression
NCT01700829
Completed
This study is designed to compare the effectiveness of two medications, Ketamine and Midazolam, for rapidly relieving suicidal thoughts in people suffering from depression. The first drug, Ketamine, is an experimental antidepressant that early studies have shown may quickly reduce suicidal thoughts, but we are not sure how well it may work. Midazolam, the comparison drug, is not thought to reduce depression or suicidal thoughts.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/10/2020
Locations: Columbia University/New York State Psychiatric Institute, New York, New York
Conditions: Major Depressive Disorder, Suicidal Ideation
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Ketamine for Refractory Chronic Migraine: a Pilot Study
NCT03896256
Completed
Ketamine is a drug used for anesthesia but at low doses it is a very effective pain reliever in several chronic conditions. Preliminary studies have shown that ketamine might be effective for patients with refractory chronic migraine, which is a severe type of headache for which patients usually have tried and failed many medications and can cause severe disability to their lives. This study will evaluate ketamine prospectively when given to patients who have "failed" an initial inpatient treatm... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/09/2020
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Migraine Headache With Intractable Migraine
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Ketamine for Depression and Alcohol Dependence
NCT01551329
Completed
The purpose of this study is to evaluate the efficacy of ketamine in reducing depressive symptoms in subjects with a comorbid major depressive episode and alcohol dependence. The investigators hypothesize the following for the present study: A single dose of ketamine will induce a rapid, robust and sustained reduction in depressive symptoms in subjects with a comorbid major depressive episode and alcohol dependence relative to placebo as defined by change in Hamilton Depression Rating Scale tot... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
03/05/2020
Locations: VA CT Healthcare Systems, West Haven, Connecticut
Conditions: Depression, Alcohol Dependence
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