Phase 1 Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual) and IV Midazolam or Ketamine
NCT04485702
Completed
Comparative Bioavailability study testing MELT-100 (midazolam and ketamine sublingual tablet) and IV midazolam or ketamine in healthy volunteers
Gender:
ALL
Ages:
55 years and above
Trial Updated:
02/22/2021
Locations: WWCT, San Antonio, Texas
Conditions: Healthy Volunteers
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Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine
NCT04767035
Completed
A Pivotal Phase 1, Randomized, Single-Dose, 4-Period, Crossover Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine under Fasted Conditions in Healthy Volunteers
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
02/22/2021
Locations: Worldwide Clinical Trials, San Antonio, Texas
Conditions: Procedural Sedation
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Ketamine Infusion for Social Anxiety Disorder
NCT02083926
Completed
* Social Anxiety Disorder (SAD) is common and causes significant impairment. * First-line treatments for Social Anxiety Disorder are only partially effective. Many SAD patients experience little or inadequate symptom relief with available treatments. * Ketamine is a potent NMDA receptor antagonist. Ketamine represents an agent with a potentially novel mechanism of action for the treatment of anxiety disorders. * Ketamine has demonstrated efficacy in the treatment of psychiatric disorders closely... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/22/2021
Locations: Connecticut Mental Health Center, New Haven, Connecticut
Conditions: Social Anxiety Disorder
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Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
NCT02397889
Completed
The purpose of this study is to study new ways to treat post-traumatic stress disorder (PTSD). Current treatments for PTSD do not work for everyone and it can take time to determine whether a person responds to a chosen treatment. The purpose of this study is to see whether ketamine, when given repeatedly intravenously can produce a quick and persistent improvement in PTSD symptoms. At higher doses, ketamine has been used for many years as an anesthetic for medical procedures, and at lower doses... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/16/2021
Locations: Depression and Anxiety Center (DAC), New York, New York
Conditions: Posttraumatic Stress Disorder (PTSD)
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Ketamine vs Hydromorphone
NCT03001843
Completed
This study will help to determine if investigators can minimize narcotic use in laparoscopic gastric bypass patients while maintaining adequate pain control. This will allow investigators to minimize the negative side effects of narcotics which is a goal in this population.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/16/2021
Locations: University of Florida, Gainesville, Florida
Conditions: Laparoscopic Gastric Bypass, Obesity, Pain, Postoperative
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Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department
NCT01538745
Completed
The purpose of this study is to compare the safety and effectiveness of intravenous low dose ketamine (LDK) to the industry standard of morphine (MOR) in regards to controlling acute pain in the emergency department. Both LDK and morphine have side effects. The amount and character of these side effects will be compared. Additionally, the degree of sedation or agitation will be specifically measured. The aim of this current study is to make this comparison and shift the evidence for LDK use fro... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
02/03/2021
Locations: Brooke Army Medical Center, San Antonio, Texas
Conditions: Abdomen, Acute, Other Acute Pain, Flank Pain, Back Pain, Musculoskeletal Pain
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The PATHFINDER Study: A Feasibility Trial
NCT04016740
Completed
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery, decrease in postoperative delirium, and decrease in long term postoperative cognitive dysfunction up to 6 months following cardiac surgery.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/27/2021
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Coronary Artery Disease, Delirium
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A Randomized, Double-Masked, Controlled, Single Site Investigator Initiated, Exploratory Study of the Midazolam/Ketamine Melt vs Ketamine Melt Alone vs Midazolam Melt Alone in Subjects Undergoing Intraocular Surgery.
NCT04725747
Unknown
This study is designed to explore the sedative and analgesic effectiveness of the Midazolam/Ketamine melt compared to Midazolam melt alone or Ketamine melt alone in subjects undergoing intraocular surgery.
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
01/22/2021
Locations: Vance Thompson Vision, Sioux Falls, South Dakota
Conditions: Anesthesia
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Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine
NCT04216888
Completed
This pilot study aims to identify predictors of response to intranasal ketamine treatment in patients with treatment-resistant depression. Participants will give a sample of blood and undergo magnetic resonance imaging before and after a single intranasal ketamine treatment. Participants will subsequently receive a second intranasal ketamine treatment.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2021
Locations: Nathan Kline Institute, Orangeburg, New York
Conditions: Depressive Disorder, Treatment-Resistant
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The Role of HNKs in the Antidepressant Effect of Ketamine
NCT03977675
Terminated
The objective of the proposed study is to examine the relationship between serum concentrations of HNK and changes in the Hamilton Depression Rating Scale (HDRS), Beck Depression Inventory (BDI), and the Profile of Mood States (POMS), as well as glutamatergic/GABAergic response. To achieve these aims the investigators propose a double-blind, uncontrolled (no placebo, no healthy control subjects) study with several different doses of ketamine. The investigators will conduct MRI scans to measure G... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2021
Locations: New York State Psychiatric Institute, New York, New York
Conditions: Major Depressive Disorder
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Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control
NCT04698772
Completed
The proposed research will be a single blinded (patient) randomized controlled prospective trial of adult patients receiving treatment for moderate to severe abdominal pain to test the hypothesis that patient satisfaction with pain control with Ketamine will be comparable to patient satisfaction with pain control using morphine when treating abdominal pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/05/2021
Locations: CHRISTUS, Corpus Christi, Texas
Conditions: Abdominal Pain
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Ketamine Infusion for Comorbid PTSD and Chronic Pain
NCT04322968
Completed
The purpose of the study is to investigate the effectiveness of low dose IV ketamine infusion in the treatment of patients with PTSD and comorbid chronic pain. Hypothesis: A single ketamine infusion should be associated with significantly greater reduction in core PTSD symptom levels after the treatment and such an effect is not only due to its analgesic properties but also through unknown mechanism of action that maybe related to NMDA/AMPA receptor modulation.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/30/2020
Locations: Ann Arbor VA Medical Center, Ann Arbor, Michigan
Conditions: PTSD, Chronic Pain
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