The PATHFINDER Study: A Feasibility Trial
NCT04016740
Completed
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery, decrease in postoperative delirium, and decrease in long term postoperative cognitive dysfunction up to 6 months following cardiac surgery.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/27/2021
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Coronary Artery Disease, Delirium
Register for Updates
A Randomized, Double-Masked, Controlled, Single Site Investigator Initiated, Exploratory Study of the Midazolam/Ketamine Melt vs Ketamine Melt Alone vs Midazolam Melt Alone in Subjects Undergoing Intraocular Surgery.
NCT04725747
Unknown
This study is designed to explore the sedative and analgesic effectiveness of the Midazolam/Ketamine melt compared to Midazolam melt alone or Ketamine melt alone in subjects undergoing intraocular surgery.
Gender:
ALL
Ages:
Between 55 years and 80 years
Trial Updated:
01/22/2021
Locations: Vance Thompson Vision, Sioux Falls, South Dakota
Conditions: Anesthesia
Register for Updates
The Role of HNKs in the Antidepressant Effect of Ketamine
NCT03977675
Terminated
The objective of the proposed study is to examine the relationship between serum concentrations of HNK and changes in the Hamilton Depression Rating Scale (HDRS), Beck Depression Inventory (BDI), and the Profile of Mood States (POMS), as well as glutamatergic/GABAergic response. To achieve these aims the investigators propose a double-blind, uncontrolled (no placebo, no healthy control subjects) study with several different doses of ketamine. The investigators will conduct MRI scans to measure G... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2021
Locations: New York State Psychiatric Institute, New York, New York
Conditions: Major Depressive Disorder
Register for Updates
Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine
NCT04216888
Completed
This pilot study aims to identify predictors of response to intranasal ketamine treatment in patients with treatment-resistant depression. Participants will give a sample of blood and undergo magnetic resonance imaging before and after a single intranasal ketamine treatment. Participants will subsequently receive a second intranasal ketamine treatment.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/20/2021
Locations: Nathan Kline Institute, Orangeburg, New York
Conditions: Depressive Disorder, Treatment-Resistant
Register for Updates
Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control
NCT04698772
Completed
The proposed research will be a single blinded (patient) randomized controlled prospective trial of adult patients receiving treatment for moderate to severe abdominal pain to test the hypothesis that patient satisfaction with pain control with Ketamine will be comparable to patient satisfaction with pain control using morphine when treating abdominal pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/05/2021
Locations: CHRISTUS, Corpus Christi, Texas
Conditions: Abdominal Pain
Register for Updates
Ketamine Infusion for Comorbid PTSD and Chronic Pain
NCT04322968
Completed
The purpose of the study is to investigate the effectiveness of low dose IV ketamine infusion in the treatment of patients with PTSD and comorbid chronic pain. Hypothesis: A single ketamine infusion should be associated with significantly greater reduction in core PTSD symptom levels after the treatment and such an effect is not only due to its analgesic properties but also through unknown mechanism of action that maybe related to NMDA/AMPA receptor modulation.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/30/2020
Locations: Ann Arbor VA Medical Center, Ann Arbor, Michigan
Conditions: PTSD, Chronic Pain
Register for Updates
The UTHealth Ketamine Project
NCT02882711
Terminated
The primary objective of this study is to determine the effectiveness of serial infusions of intravenous (IV) ketamine in adults with treatment resistant depression (TRD).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/06/2020
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Treatment Resistant Depression, Major Depressive Disorder, Bipolar Disorder
Register for Updates
Anesthetic Techniques in EP Patients
NCT02664922
Terminated
The purpose of this study is to compare different combinations of anesthetic drugs (cause loss of sensation) in terms of effectiveness, adverse effects, pain relief, and patient comfort for cardiac electrophysiology procedures. In addition, the investigators are studying the different anesthetic combinations to determine the best approach in terms of identification and treatment of arrhythmias.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/21/2020
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Cardiac Disease
Register for Updates
Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department
NCT04266288
Completed
The purpose of this study is to examine the effect of a low-dose ketamine infusion on depression symptoms within the Emergency Department (ED) visit, and healthcare utilization after leaving the ED, when administered in the ED for depression or suicidal ideation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/31/2020
Locations: MercyOne Des Moines Medical Center, Des Moines, Iowa
Conditions: Depression, Depression Severe, Depression Acute, Depression and Suicide, Suicidal Ideation
Register for Updates
Ketamine for Low Mood States in the ER
NCT01209845
Completed
The investigators hope to see if a commonly used drug such as ketamine could help depressed ER patients feel better and improve their mood quickly.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2020
Locations: Yale New Haven Hospital Emergency Department, New Haven, Connecticut
Conditions: Depression, Suicide Ideation
Register for Updates
EEG Studies of Ketamine General Anesthesia
NCT03553758
Completed
We are doing this research study to find out how and where ketamine acts in the brain. Ketamine is an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain by putting you in an unconscious state). We will look at the brain using a machine that records the brain's electrical activity, called an electroencephalogram (EEG). We will assess how it impacts patient's pain responses.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
08/14/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anesthesia
Register for Updates
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)
NCT02422290
Completed
This pilot study is proposed to determine the acceptability, feasibility and potential efficacy of ketamine, a medication that modulates glutamate in the brain, as a rapid treatment for obsessive-compulsive disorder (OCD) symptoms in adolescents and young adults with OCD. This study will recruit 6 youth (ages 14-22) who are diagnosed with clinically significant OCD and have failed at least one adequate trial of a Serotonin Reuptake Inhibitor (SRI) medication and a course of Cognitive-Behavioral... Read More
Gender:
ALL
Ages:
Between 14 years and 22 years
Trial Updated:
08/14/2020
Locations: New York State Psychiatric Institute/Columbia University, New York, New York
Conditions: Obsessive-Compulsive Disorder
Register for Updates