Sub-dissociative Ketamine for the Management of Acute Pediatric Pain
NCT01951963
Completed
The proposed trial is a prospective, double blinded, randomized control trial with the primary aim of determining whether a single, sub-dissociative dose of ketamine will decrease the total narcotic requirements of pediatric patients requiring intravenous analgesia in an urban emergency department (ED) compared to a group of patients who receive morphine alone for pain management. Patients are randomized to receive either a single bolus of ketamine (0.3 mg/kg) or a single bolus of morphine (0.05... Read More
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
06/05/2018
Locations: Regions Hospital, Saint Paul, Minnesota
Conditions: Pain
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Ketamine Anesthesia for Improvement of Depression in ECT
NCT02752724
Completed
The purpose of this prospective randomized clinical trial is to determine if patients receiving ketamine as a part of general anesthesia during electroconvulsive therapy (ECT) rather than standard of care will have improvement in symptoms of depression after a course of ECT treatments. The investigators hypothesize that utilization of ketamine for induction of general anesthesia during ECT treatments will improve symptoms of depression better than standard care. This study is ONLY open to patie... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/01/2018
Locations: VA Puget Sound Health Care System, Seattle, Washington
Conditions: Major Depressive Disorder
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Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)
NCT01920555
Completed
This study is looking at the efficacy, durability, safety, and tolerability of multiple single doses of Ketamine vs. active placebo for treating patients with treatment resistant depression who are taking an antidepressant that is not working for them.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/24/2018
Locations: Stanford University, Palo Alto, California +5 locations
Conditions: Treatment Resistant Depression
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A Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal Fusion
NCT03274453
Completed
The aim of the proposed study is to examine the effectiveness of low dose postoperative ketamine infusion as an analgesic adjuvant to morphine pca in opioid tolerant and opioid naïve patients after major spine surgery. Primary endpoints of the study are to determine the effectiveness of postoperative ketamine infusion in for the reduction of postoperative pain and opioid requirements.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
05/15/2018
Locations: New York University School of Medicine, New York, New York
Conditions: Spinal Fusion
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Pediatric Ketamine Study for Pain Management
NCT02388321
Terminated
Direct comparison of intranasal sub-dissociative dose ketamine with intranasal fentanyl for the treatment of moderate to severe pain in pediatric patients in the emergency department.
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
05/07/2018
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain
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Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency Department
NCT02417298
Terminated
Pain associated with sickle cell disease is a common emergency department visit. It is also frequently associated with a high emergency department recidivism rate for pain control and admissions to the hospital. Opiates are considered the first line therapy for acute flares and to manage chronic pain. This often times leads to a stigma of being "opiate seekers" or "frequent fliers". With this study, we wish to explore whether adding ketamine to standard acute opiate therapy (morphine or dilaudid... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2018
Locations: The Brooklyn Hospital Center, Brooklyn, New York
Conditions: Pain, Sickle Cell Disorder
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The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial
NCT01690988
Completed
Delirium is a medical term or condition that includes a temporary inability to focus attention and to think clearly. Delirium occurs commonly (10% to 70%) in patients older than 60 undergoing large surgeries. The purpose of this study is to test rigorously whether a drug called ketamine can decrease the chance that patients will experience delirium after their surgery. The investigators are also testing whether ketamine decreases postoperative pain, postoperative opioid consumption, postoperativ... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
05/02/2018
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Delirium
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Effects of TS-134 on Ketamine-induced BOLD Signals in Healthy Subjects
NCT03141658
Completed
The purpose of this study is to evaluate the effects of TS-134 on ketamine-induced BOLD signals in ROIs in resting fMRI in healthy adult subjects.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/27/2018
Locations: New York State Psychiatric Institute, New York, New York
Conditions: Healthy Volunteers
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CYP2B6 Polymorphisms in Ketamine
NCT01988922
Completed
This research study will determine if genetic variation in CYP2B6 affects how the body metabolizes ketamine.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/13/2018
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Healthy Volunteers
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Physiological and Cognitive Biomarkers for Ketamine's Antidepressant Effects
NCT02669043
Terminated
Anxious depression is a particularly difficult-to-treat subtype of depression. Patients with anxious depression do not respond as well to currently available antidepressant medications. Nevertheless, in previous studies, low dose IV ketamine, which rapidly decreases symptoms of depression within hours in many patients with "treatment-resistant" depression, has been associated with superior efficacy in those individuals with anxious compared with non-anxious depression. In order to understand thi... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/22/2018
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Depression
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IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures
NCT03466242
Unknown
The primary objective of this study is to evaluate the sedative, and analgesic effects of intranasal (IN) Dexmedetomidine (DEX) in children presenting to a Pediatric Emergency Department (PED) who undergo conscious sedation for reduction of closed distal forearm fractures when compared to those receiving intravenous (IV) Ketamine. The secondary objective is to compare each sedation technique for safety and procedural outcomes.
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
03/08/2018
Locations: Phoenix Children's Hospital, Phoenix, Arizona
Conditions: Conscious Sedation, Distal Radius Fracture
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Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder
NCT01613820
Withdrawn
Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. Scopolamine infusions produced also a significant improvement in depression that was sustained over time. We therefore plan to investigate the feasibility and efficacy of open-label repeated intravenous administration of ketamine and scopolamine combined in this population of severely depressed, treatment-resistant patients. The results from this study could lead to the developmen... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/15/2018
Locations: Depression Clinical and Reseach Program - MGH, Boston, Massachusetts
Conditions: Major Depressive Disorder
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