Ketamine: Comparison of IV Push vs. IV Drip
NCT02363270
Completed
Our previous published research comparing the efficacy of intravenous ketamine to morphine has shown ketamine to provide equivalent relief of moderate to severe acute pain in emergency medicine patients. Secondary analysis of the previous published research has also revealed ketamine to have statistically more side effects. The investigators believe that increasing the time of administration of the ketamine, from a push injection to a drip infusion, will minimize the side effects experienced by... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/19/2017
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Pain
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Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus
NCT02726867
Withdrawn
The purpose of the study is to evaluate the efficacy and safety of levetiracetam , lacosamide and ketamine treatment of refractory status epilepticus. This will be a randomized, open-label, four-arm pilot study comparing time to cessation of refractory status epilepticus, determined by continuous EEG monitoring, in patients with refractory status epilepticus. Patients with status epilepticus who have been treated with standard dose lorazepam (or midazolam) and ≥ 1000 mg phenytoin with documented... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/28/2017
Locations: MidAtlantic Epilepsy and Sleep Center, Bethesda, Maryland
Conditions: Epilepsy, Status Epilepticus
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Ketamine Patient-Controlled Analgesia for Acute Pain
NCT02062879
Terminated
This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have similar or improved objective pain scores. Patients receiving ketamine are also expected to have shorter duration of supplemental oxygen requirement, fewer episodes of oxygen desaturation, improved pulmonary toilet, lower use of antiemetics, and shorter times to first bowe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2017
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Acute Pain, Multiple Trauma, Fractures
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Ketamine for Depression and Suicide Risk
NCT02094898
Completed
The purpose of this research study was to find out if the medication known as ketamine could help the symptoms of depression. This drug is approved by the U.S. Food and Drug Administration (FDA) as an anesthetic agent; however, it is not approved for use in depression treatment. The FDA allowed the use of this drug in this research study.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/10/2017
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Depression, Suicide
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Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
NCT00516503
Completed
RATIONALE: Baclofen-amitriptyline-ketamine (BAK) gel may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether BAK gel is more effective than a placebo in treating peripheral neuropathy caused by chemotherapy . PURPOSE: This randomized phase III trial is studying BAK gel to see how well it works compared with a placebo in treating peripheral neuropathy caused by chemotherapy in patients with cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2017
Locations: Mayo Clinic Scottsdale, Scottsdale, Arizona +164 locations
Conditions: Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Neurotoxicity, Pain, Unspecified Adult Solid Tumor, Protocol Specific
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Immunomodulatory Properties of Ketamine in Sepsis
NCT01089361
Completed
The aim of the study is to assess the effect of short-term infusion of ketamine at analgesic dosage on the immune response, morbidity and mortality among patients suffering from septic shock. We hypothesize that ketamine will modulate the cytokine response to sepsis and reduce morbidity and mortality.
Gender:
ALL
Ages:
Between 21 years and 100 years
Trial Updated:
07/21/2017
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Sepsis
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Ketamine For Acute Treatment of Pain in Emergency Department
NCT02306759
Completed
The aim of the study is to compare the safety \& efficacy of low dose ketamine and morphine versus morphine alone for acute generalized pain in the Emergency Department (ED). The investigators are also interested to investigate whether low-dose ketamine is a safe and effective alternative option to opioids for the acute treatment of pain in the Emergency Department. The agents that are available in the department includes acetaminophen, non-steroidal anti-inflammatory (NSAIDS) and opioids. In m... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/11/2017
Locations: The Brooklyn Hospital Center, Brooklyn, New York
Conditions: Pain
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Low Dose Ketamine as an Adjunct to Fentanyl in Outpatient Tonsillectomy
NCT00587665
Completed
Comparing patients receiving subanesthetic doses of Ketamine vs placebo to see if it can reduce narcotic needs for patients receiving a tonsillectomy and adenoidectomy
Gender:
ALL
Ages:
Between 3 years and 12 years
Trial Updated:
06/12/2017
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Pain
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Intranasal Ketamine Versus Intramuscular Ketamine for Procedural Sedation in Pediatric Patients
NCT01170247
Terminated
The purpose of this study is to determine if intranasal ketamine is equally as effective and safe as intramuscular ketamine for procedural sedation in pediatric patients.
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
06/03/2017
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Sedation
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A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion
NCT02424591
Completed
Postoperative pain is severe after major spine surgery. Opioids such as morphine and hydromorphone are routinely used for postoperative pain control. These drugs have significant side effects, most importantly respiratory depression, nausea, constipation and tolerance. Moreover, many spine surgery patients have used opioid pain medication for back pain long term, leading to pre-surgical opioid tolerance and increased postoperative pain. This has led to a search for adjuvant medications to reduce... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2017
Locations: NYU School of Medicine, New York, New York
Conditions: Postoperative Pain
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Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions
NCT00596050
Completed
There are multiple retrospective studies detailing the use of etomidate in pediatric procedural sedation but few to no prospective clinical trials. None have compared etomidate to ketamine, currently the most commonly used sedative in the emergency department for pediatric procedural sedation. The investigators propose a randomized, controlled trial comparing etomidate versus ketamine for procedural sedation for fracture reduction for children presenting with extremity fracture requiring sedatio... Read More
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
05/08/2017
Locations: St. Christopher's Hospital for Children, Philadelphia, Pennsylvania
Conditions: Conscious Sedation Failure During Procedure
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Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery
NCT01983020
Completed
This study has been designed as a controlled clinical trial to evaluate the efficacy of brief lidocaine infusion, brief ketamine infusion and a lidocaine/ketamine combined infusion when added to conventional opioid therapy following major spine surgery, as well as to evaluate the effects of the lidocaine/ketamine pain protocol on the feasibility of performing routine intraoperative neurophysiology during spine surgery in adults and determine whether this infusion protocol is compatible with intr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2017
Locations: Beth Israel Medical Center, New York, New York
Conditions: Postoperative Pain
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