Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery
NCT01106846
Terminated
Hypothesis: The intraoperative administration of ketamine will result in a 30% reduction in opiate requirement following endometrial ablation surgery and the intraoperative administration of ketamine will result in a decreased time to meet discharge criteria in the PACU following endometrial ablation surgery. The research question is "Does intraoperative administration of ketamine result in decreased postoperative opiate requirement and time to discharge from the postanesthesia recovery unit (P... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
07/20/2015
Locations: Northwestern University, Chicago, Illinois +1 locations
Conditions: Pain
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Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
NCT01260662
Completed
This will be a randomized trial of propofol versus the combination of propofol and ketamine for procedural sedation for procedures in the Emergency Department (ED). Propofol produces sedation, hypnosis, and dense amnesia, and is commonly used in the ED at Hennepin County Medical Center (HCMC) for procedural sedation. Ketamine is a dissociative anesthetic that is also frequently used in the ED in children and sometimes in adults. It has been proposed that by combining the two agents, the negative... Read More
Gender:
ALL
Ages:
1 year and above
Trial Updated:
06/15/2015
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: Procedural Sedation
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Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting
NCT02303847
Unknown
This project is a pilot study to evaluate the analgesic and opioid-sparing effects of ketamine in an ultra-low dose oral formulation as a novel intervention for treatment of chronic non-cancer pain in opioid-tolerant patients in the primary care outpatient setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/24/2015
Locations: Pioneer Family Practice, Lacey, Washington
Conditions: Chronic Pain
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N-acetylcysteine and NMDA Antagonist Interactions
NCT00611897
Completed
This study tests the hypothesis that extrasynaptic mechanisms are critically linked with cognitive effects of NMDA antagonism as evidenced by event-related potentials (ERPs) in healthy humans.
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
05/07/2015
Locations: VHA Connecticut, West Haven, Connecticut
Conditions: Cognitive Dysfunction
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Anesthetics in Rhytidoplasty - A Comparison Study
NCT02410460
Completed
This study is a prospective, double-blind, randomized comparison study of different anesthesia methods in rhytidoplasty surgery. The study is designed to determine whether post-operative side-effect profiles in patients undergoing elective cosmetic facelift surgery can be decreased through the use of propofol/ketamine anesthesia with bispectral monitoring (PKA-BIS) rather than general anesthesia, without increasing intra-operative time, side-effect profiles, or patient recall. Approximately 30 s... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/06/2015
Locations: Mercy Facial Plastic Surgery Center, Springfield, Missouri
Conditions: Rhytidoplasty
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Study Testing Ketamine Sublingual Wafer After Wisdom Tooth Extraction
NCT02356965
Completed
The purpose of the study is to test two different doses of ketamine sub-lingual (under the tongue) wafer against placebo to see how effective the medication is to treat moderate to severe pain after wisdom tooth extraction.
Gender:
ALL
Ages:
Between 18 years and 38 years
Trial Updated:
03/24/2015
Locations: Jean Brown Research, Salt Lake City, Utah
Conditions: Pain
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Subanesthetic IV Bolus Ketamine in the Treatment of Acute Depression
NCT02378415
Terminated
The objective of this double-blinded placebo-controlled pilot study is to determine whether a single sub-anesthetic rapid IV bolus dose of ketamine administered to acutely depressed patients with or without suicidality has a significant rapid antidepressant effect in the acutely depressed population. The study will pursue as a primary outcome measure whether a significant reduction in depressive symptoms, as assessed by the BSS and BHS, occurs shortly after administration of ketamine at 40, 80,... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/03/2015
Locations: Naval Medical Center San Diego, San Diego, California
Conditions: Acute Depression
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Ketamine for Acute Suicidal Ideation in the Emergency Department: Randomized Controlled Trial
NCT01892995
Unknown
This study will enroll patients presenting to the emergency department with acute suicidal ideation meeting inclusion and exclusion criteria. Patients will be randomized to one of three arms: ketamine (intervention) or diphenhydramine (control) or placebo (control). Serial measurements will be made in the ED and at follow-up intervals.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/13/2015
Locations: Brooke Army Medical Center, Fort Sam Houston, Texas
Conditions: Suicide
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Use of Ketamine vs Methohexital for Electroconvulsive Therapy (ECT) on Patient Recovery and Re-orientation Time
NCT01567852
Completed
When undergoing ECT treatments, patient recovery time and re-orientation time may be shorter using ketamine for induction than using methohexital.
Gender:
ALL
Ages:
All
Trial Updated:
12/15/2014
Locations: University of New Mexico, Albuquerque, New Mexico
Conditions: Post-anesthesia Recovery, Orientation
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Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial
NCT01269307
Completed
The purpose of this study is to determine if procedural sedation utilizing a 1:1 mixture of propofol and ketamine is equivalent in complications, patient and physician satisfaction, post-procedure pain level, and procedural outcome to propofol sedation alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/11/2014
Locations: University of Utah, Salt Lake City, Utah
Conditions: Sedation
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A Study to Assess the Analgesic Properties of a Sublingual Wafer Formulation of Ketamine Following Third Molar Extraction
NCT02199678
Completed
This is a Phase 2, randomized, multicenter, parallel group, double-blind, dose-ranging, placebo-controlled evaluation of the analgesic efficacy, safety and pharmacokinetics of ketamine sublingual wafer in adult subjects who experience post operative pain after undergoing third molar extraction.
Gender:
ALL
Ages:
Between 18 years and 38 years
Trial Updated:
11/19/2014
Locations: Lotus Clinical Research, LLC, Pasadena, California +1 locations
Conditions: Pain
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SNAP VS BIS(OAA/S) Scale During a Sedation Regimen With and Without Ketamine
NCT01250418
Terminated
The study question: Does the SNAP-Index (SI) correlates better with the OASS than the BIS Monitor during sedation with ketamine? The study hypothesis: Since the SNAP II monitor seems to be more responsive during emergence of anesthesia, it will have a better correlation with the OASS than the BIS monitor with the use of ketamine.
Gender:
FEMALE
Ages:
Between 18 years and 64 years
Trial Updated:
08/18/2014
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Pain
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