Optimization of IV Ketamine for Treatment Resistant Depression
NCT00768430
Completed
Existing treatments for major depressive disorder (MDD) generally take weeks to months to exert their maximal benefit. There is an urgent need to develop rapid-acting treatments for MDD. Ketamine, a high-affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, has been used as a standard intravenous (IV) anesthetic agent for many years in both pediatric and adult patients. Beyond its well-established role in anesthesia and pain management, there is emerging evidence that ketamine may... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
12/27/2013
Locations: Mount Sinai School of Medicine, New York, New York +1 locations
Conditions: Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Register for Updates
Ketamine Anesthesia in Electroconvulsive Therapy
NCT01367119
Completed
Does the use of ketamine as the anesthetic medication in electroconvulsive therapy (ECT) accelerate the antidepressant effect of ECT? The study hypothesis was that depressed subjects receiving ECT with ketamine as the anesthetic agent would demonstrate a faster rate of improvement, defined as lower depression ratings after the second ECT than depressed patients receiving ECT with the usual anesthetic agent.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2013
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Depression
Register for Updates
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
NCT01309581
Terminated
The primary objectives of this study are to investigate the potential for ketamine anesthesia to increase the antidepressant efficacy of Electroconvulsive therapy (ECT) and to decrease acute ECT-induced adverse cognitive effects.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/29/2013
Locations: Icahn School of Medicine at Mount Sinai, New York City, New York
Conditions: Major Depression, Bipolar Depression
Register for Updates
Dexmedetomidine Sedation With Third Molar Surgery
NCT01017237
Terminated
Intravenous sedation is used frequently for the relief of pain and anxiety associated with oral surgical procedures performed under local anesthesia. The purpose of this study is to learn about patient and surgeon satisfaction with sedation using Dexmedetomidine in combination with midazolam alone or with midazolam plus low dose ketamine while having wisdom teeth removed. The sedation produced by dexmedetomidine is unique in that it mimics natural sleep, a unique quality not shared by other dru... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
05/07/2013
Locations: University of North Carolina School of Dentistry, Chapel Hill, North Carolina
Conditions: Anesthesia
Register for Updates
Modifying Virtual Reality Analgesia With Low-Dose Pain Medication
NCT01840774
Unknown
The purpose of this study is to determine how pain relief is modified when the investigators combine the Virtual Reality based Snow World game with certain pain medications.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/25/2013
Locations: University of Washington, Seattle, Washington
Conditions: Virtual Reality Therapy
Register for Updates
A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters
NCT01065350
Completed
This is a pilot study to compare the hemodynamic changes that occur during induction with a novel drug combination known as ketofol (propofol and ketamine admixture with that of propofol alone (prototypic anesthesia induction agent). Propofol and ketamine are widely used as induction agents and their effects on patient hemodynamics are well known. Some of these drug-induced hemodynamic changes are undesirable and lead to deleterious effects on patient hemodynamics. We seek to investigate the hem... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/21/2013
Locations: Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Blood Pressure
Register for Updates
Neuromodulation to Facilitate the Effect of Ketamine
NCT01816958
Completed
application of external neuromodulation along with ketamine infusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2013
Locations: The Neuroscience Center, Deerfield, Illinois
Conditions: Depression, Chronic Pain, Substance Abuse
Register for Updates
Ketamine Pharmacokinetics in Children Having Heart Surgery
NCT00598195
Completed
What are the pharmacokinetics of ketamine in infants and children requiring ketamine for induction of anesthesia for cardiac surgery that requires CPB? Specific Aim 1: To determine the pharmacokinetic parameters of a single intravenous bolus dose of ketamine in infants and children undergoing cardiac surgery with and without CPB (cardio-pulmonary bypass). Specific Aim 2: To describe the disposition of ketamine's primary active metabolite, norketamine,following a single intravenous bolus dose of... Read More
Gender:
ALL
Ages:
Between 1 day and 6 years
Trial Updated:
02/26/2013
Locations: Arkansas Children's Hospital, Little Rock, Arkansas
Conditions: C.Surgical Procedure; Cardiac
Register for Updates
Oral Ketamine for Control of Chronic Pain in Children
NCT01369680
Completed
The study is a maximum tolerated dose finding study for oral, chronic, daily administration of oral ketamine (by mouth) in children with long-term daily pain.
Gender:
ALL
Ages:
Between 8 years and 22 years
Trial Updated:
02/11/2013
Locations: University of Rochester, Rochester, New York
Conditions: Chronic Pain
Register for Updates
Fentanyl vs. Low-Dose Ketamine for the Relief of Moderate to Severe Pain in Aeromedical Patients
NCT01169025
Withdrawn
Often, patients transported by aeromedical systems do not receive enough medication to control and relieve their pain. The purpose of this study is to determine if pain treatment with intravenous (IV) ketamine is a better way to treat aeromedical patients' pain than the current treatment practices.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/01/2012
Locations: University of Utah Medical Center, Salt Lake City, Utah
Conditions: Trauma, Pain
Register for Updates
Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects
NCT00690170
Completed
This study examines the interactive effects of ketamine and nicotine.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
05/08/2012
Locations: Veterans Administration Hospital, West Haven, Connecticut
Conditions: Healthy Subjects
Register for Updates
Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)
NCT00997321
Completed
This study is a clinical trial of moderate sedation with propofol versus moderate sedation with ketamine for procedural sedation in the Emergency Department.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2012
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: Sedation
Register for Updates