The Effects of Sedatives on Tobacco Use Disorder Version 2
NCT05505630
Active Not Recruiting
Double-blind, placebo-controlled, randomized mechanistic clinical trial to test an intravenous dose of either ketamine, midazolam, dexmedetomidine, or a placebo (saline) on cigarette smoking behavior, craving, and neural effects.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
07/03/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Tobacco Smoking
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Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
NCT06317636
Active Not Recruiting
The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression. We do not know whether ketamine will be more effective than placebo under these circumstances. This study aims to: * Evaluate whether placebo is non-inferior to ketamine in treating chronic pain and depression, when delivered under propofol sedation * Confirm that propofol sedation is a safe way to keep participants blinded to treatm... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/01/2025
Locations: Stanford University, Stanford, California
Conditions: Chronic Pain, Depression
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Ketamine-enhanced Prolonged Exposure Therapy in PTSD
NCT04560660
Active Not Recruiting
The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as compared to placebo to reduce symptoms of Posttraumatic Stress Disorder (PTSD) among Veteran receiving Prolonged Exposure Therapy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/01/2025
Locations: Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
Conditions: PTSD
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Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
NCT06903819
Not Yet Recruiting
The goal of this clinical trial is to learn whether a single dose of ketamine during surgery can help lower pain, reduce the need for opioid medications, and improve mental health recovery in adults with serious orthopedic injuries. The main questions it aims to answer are: Does ketamine lower pain after surgery? Does ketamine help reduce how much opioid medicine participants need? Does ketamine improve symptoms of depression and post-traumatic stress disorder (PTSD)? Researchers will compare p... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/01/2025
Locations: Texas Tech University Health Sciences Center Lubbock, Lubbock, Texas +1 locations
Conditions: Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use, Depression, Post-traumatic Stress Disorder (PTSD)
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Observational Study of Ketamine Infusions for the Treatment of Chronic Pain
NCT05477004
Enrolling By Invitation
This observational study will collect prospectively specified data on patient characteristics and clinically relevant outcomes in patients who receive a ketamine infusion at Stanford Pain Management Center for the treatment of chronic pain, with the goal of identifying treatment responders and relationships between patient characteristics and treatment response.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Stanford University, Stanford, California
Conditions: Chronic Pain
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Neural Circuit Effects of Ketamine in Depression
NCT06213324
Recruiting
This project is designed to examine the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in humans with depression, as well as the acute and sustained effects of ketamine on agACC activation and depression symptoms.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/30/2025
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Major Depressive Disorder
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Reducing Pain With Methadone and Ketamine in Liver Transplant
NCT06868589
Recruiting
The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery. The main questions it aims to answer are: * What impact does using methadone and ketamine during a deceased donor liver transplant have on pain after surgery? * Does the use of methadone and ketamine also have an impact on mental confusion (delirium) after surgery? Researchers will compare the use of methadone and ketamine to standar... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/29/2025
Locations: Lahey Hospital and Medical Center, Burlington, Massachusetts +1 locations
Conditions: Liver Transplantation
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Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
NCT03573349
Active Not Recruiting
This is a feasibility study and the goal of this project is to evaluate whether peak ACC GABA and glutamate, quantified as a CSF-corrected absolute concentration percent change from baseline, is associated with clinical remission, Montgomery Asberg Depression Rating Scale (MADRS) total score of \<10, to the anti-glutamatergic antidepressant ketamine. As MRS is expensive, we also aim to study a correlation between change in peripheral metabolites (GABA and glutamate) and central GABA and glutama... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/25/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Major Depressive Disorder, Treatment Resistant Depression, Bipolar Depression
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Ketamine Treatment of Youth Suicide Attempters
NCT04763343
Recruiting
Ketamine, an NMDA antagonist, has been shown to have rapid anti- suicidal effects. However, its safety and efficacy and special populations has not been investigated and documented. Several reports in adults suggest rapid decrease of suicidal ideation. In the last decade there is an alarming increase of the number of suicide attempts in patients ages 14-30. Suicide is the second leading cause of death in this population. Patients with previous history of suicide attempt, are even in a higher ris... Read More
Gender:
ALL
Ages:
Between 14 years and 30 years
Trial Updated:
06/25/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Suicide, Attempted
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Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
NCT04032301
Completed
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability. Veterans with both PTSD and MDD (PTSD+MDD) have been shown to be at much greater suicidal risk than individuals with only one of these disorders. Ketamine given as repeated infusions has been shown to be effective in rapidly reducing PTSD and MDD symptoms in treatment resistant PTSD+MDD individ... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/25/2025
Locations: Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota
Conditions: Post-Traumatic Stress Disorders, Major Depressive Disorder
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Anhedonia, Development, and Emotions: Phenotyping and Therapeutics
NCT05487885
Completed
The goal of the ADEPT Study is to understand anhedonia in young people and how it changes based on treatments targeting the brain circuit underlying it. Anhedonia is a challenging mental health symptom that involves difficulty with motivation to experience pleasant events. This study could help develop treatments for people whose depression does not improve with traditional treatments. The ADEPT Study includes two phases. In Phase 1, participants are asked to go through a series of activities t... Read More
Gender:
ALL
Ages:
Between 15 years and 25 years
Trial Updated:
06/24/2025
Locations: Loeffler Building, Pittsburgh, Pennsylvania
Conditions: Depression, Anhedonia
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Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
NCT05037123
Active Not Recruiting
The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain. Participants randomized to the first arm will receive a 0.35 mg/kg dose after induction, followed by a 0.25 mg/kg/hr infusion during surgery (up to a maximum of 6 hours) and continued for 2 hours postoperatively. Participants in the second arm will receive a single dose of 0.6 mg/kg of ketamine in the post-anesthesia care unit, and the final group will serve as the c... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +13 locations
Conditions: Chronic Postsurgical Pain
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