Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
NCT04592809
Active Not Recruiting
This project aims to examine the signal of efficacy of ketamine, a rapidly acting medication shown to decrease suicidality in adults in as short as hours or days, as opposed to weeks. The study design is a double-blind, randomized, active-control trial of adolescents (ages 13-18 years) with recent suicidal behaviors (suicide attempt or increased suicidal ideation). All participants must be receiving standard of care treatment which may range broadly from both outpatient and inpatient programs w... Read More
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
04/22/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Suicide, Attempted, Suicide and Depression, Suicide Threat
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Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
NCT05327699
Recruiting
The main purpose of this study is to investigate the effects of ketamine on decision-making and emotion processing in a sample of individuals diagnosed with Major Depressive Disorder (MDD).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/18/2025
Locations: Emory University, Atlanta, Georgia
Conditions: Major Depressive Disorder
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Ketamine Effects on Learning In Eating Disorders
NCT06736769
Not Yet Recruiting
This is a single site, single dose clinical trial of intravenous (IV) ketamine for medically hospitalized adolescents and young adults with anorexia nervosa or atypical anorexia nervosa. Eating disorder symptoms will be measured pre- and post-ketamine infusion. Investigators hypothesize that ketamine will increase cognitive flexibility, making medical hospitalizations less distressing by improving the ability to learn new, positive associations with food.
Gender:
ALL
Ages:
Between 16 years and 26 years
Trial Updated:
04/17/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Anorexia Nervosa, Atypical Anorexia Nervosa
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Ketamine for Opioid Use Disorder
NCT06943859
Not Yet Recruiting
The goal of this clinical trial is to learn if ketamine works to reduce craving for opioids in adults entering methadone treatment for opioid use disorder. The main questions it aims to answer are: * Does ketamine reduce craving for opioids in patients with opioid use disorder? * Does ketamine reduce symptoms of opioid withdrawal such as depression, pain, and poor sleep quality? * Do patients who take ketamine stay in methadone treatment longer, and/or have better treatment outcomes than those... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2025
Locations: University of Maryland Addiction Programs and Affiliated Clinics, Baltimore, Maryland
Conditions: Opioid Use Disorder
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Ketamine for Sedation in Severe Traumatic Brain Injury
NCT06429657
Suspended
This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with severe traumatic brain injury.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/16/2025
Locations: Brooke Army Medical Center, Fort Sam Houston, Texas
Conditions: Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive
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Ketamine Treatment of Youth Suicide Attempters
NCT04763343
Recruiting
Ketamine, an NMDA antagonist, has been shown to have rapid anti- suicidal effects. However, its safety and efficacy and special populations has not been investigated and documented. Several reports in adults suggest rapid decrease of suicidal ideation. In the last decade there is an alarming increase of the number of suicide attempts in patients ages 14-30. Suicide is the second leading cause of death in this population. Patients with previous history of suicide attempt, are even in a higher ris... Read More
Gender:
ALL
Ages:
Between 14 years and 30 years
Trial Updated:
04/15/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Suicide, Attempted
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Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers
NCT06001372
Terminated
The goal of this open-label clinical trial is to assess the feasibility of Ketamine-assisted psychotherapy (KAP) studies for adults with non-operable GI cancers suffering with existential distress. The main questions it aims to answer are: * Is it feasible to conduct a KAP study with this population? * What is the safety and tolerability of KAP in this population? * How prevalent is existential distress in this population? Participants will undergo KAP administered as standard of care at the H... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: Huntsman Cancer Institute, Salt Lake City, Utah
Conditions: Gastrointestinal Cancer, Depression, Anxiety
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Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
NCT05037123
Active Not Recruiting
The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain. Participants randomized to the first arm will receive a 0.35 mg/kg dose after induction, followed by a 0.25 mg/kg/hr infusion during surgery (up to a maximum of 6 hours) and continued for 2 hours postoperatively. Participants in the second arm will receive a single dose of 0.6 mg/kg of ketamine in the post-anesthesia care unit, and the final group will serve as the c... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +13 locations
Conditions: Chronic Postsurgical Pain
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Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
NCT06767566
Recruiting
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting. Ketamine is expected to exert different kinetics during the physiologic state of post-pregnancy. The goal in conducting this study is to better understand the pharmacokinetics and pharmacodynamics of postpartum ketamine infusion. A secondary goal is to compare these kinetics to reproductive age matched controls and to assess sex diffe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania +1 locations
Conditions: Pain, Postpartum Depression
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Ketamine for Veterans With Parkinson's Disease
NCT06231563
Recruiting
Parkinson's disease (PD) is a devastating illness that has a growing impact on Veterans. One of the most disabling symptoms is depression, which is common in PD and linked to poor quality of life and higher risk of suicide. Unfortunately, there is a lack of effective treatments for depression in PD. Ketamine, which has rapid and potent antidepressant effects, is a potential option but has not been tested in Veterans with PD. Studies in rodents show that ketamine may not only improve depression i... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
04/11/2025
Locations: San Francisco VA Medical Center, San Francisco, CA, San Francisco, California
Conditions: Parkinson's Disease
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Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
NCT02461927
Completed
The investigators will compare 3 treatment groups (ketamine plus naltrexone vs. ketamine alone vs. placebo) for treating major depressive disorder (MDD) and alcohol use disorder (AUD) in an 8-week randomized, double-blind, placebo-controlled, between-subjects trial. First, prior to the double-blind trial, the investigators will conduct an open-label trial that will include 5 patients with comorbid MDD and AUD to test safety and efficacy of repeated ketamine treatment (0.5 mg/kg; once a week for... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
04/09/2025
Locations: VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut
Conditions: Major Depressive Disorder, Alcohol Use Disorder
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The Dreamy Jet Study
NCT06919198
Not Yet Recruiting
The goal of this clinical trial is to see if a device known as a jet-injection system can help deliver a single dose of a sedating medication with less pain and stress than current methods. Participants will receive a dose of the sedative in their arm or thigh before their procedure at the sedation clinic.
Gender:
ALL
Ages:
Between 2 years and 15 years
Trial Updated:
04/02/2025
Locations: University of Wisconsin - Madison, Madison, Wisconsin
Conditions: Sedation, Blood Drawing Procedure, Immunization, IV Placement
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