FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression
NCT06620042
Recruiting
This is a prospective open-label observational study of patients with treatment resistant bipolar depression referred for intravenous ketamine, with an interventional component of fMRI.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/17/2025
Locations: Cleveland Clinic Lutheran Hospital, Cleveland, Ohio +1 locations
Conditions: Bipolar Depression, Treatment Resistant Bipolar Depression
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Ketamine for Opioid Use Disorder
NCT06943859
Not Yet Recruiting
The goal of this clinical trial is to learn if ketamine works to reduce craving for opioids in adults entering methadone treatment for opioid use disorder. The main questions it aims to answer are: * Does ketamine reduce craving for opioids in patients with opioid use disorder? * Does ketamine reduce symptoms of opioid withdrawal such as depression, pain, and poor sleep quality? * Do patients who take ketamine stay in methadone treatment longer, and/or have better treatment outcomes than those... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2025
Locations: University of Maryland Addiction Programs and Affiliated Clinics, Baltimore, Maryland
Conditions: Opioid Use Disorder
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Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers
NCT06001372
Terminated
The goal of this open-label clinical trial is to assess the feasibility of Ketamine-assisted psychotherapy (KAP) studies for adults with non-operable GI cancers suffering with existential distress. The main questions it aims to answer are: * Is it feasible to conduct a KAP study with this population? * What is the safety and tolerability of KAP in this population? * How prevalent is existential distress in this population? Participants will undergo KAP administered as standard of care at the H... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: Huntsman Cancer Institute, Salt Lake City, Utah
Conditions: Gastrointestinal Cancer, Depression, Anxiety
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Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
NCT06767566
Recruiting
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting. Ketamine is expected to exert different kinetics during the physiologic state of post-pregnancy. The goal in conducting this study is to better understand the pharmacokinetics and pharmacodynamics of postpartum ketamine infusion. A secondary goal is to compare these kinetics to reproductive age matched controls and to assess sex diffe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania +1 locations
Conditions: Pain, Postpartum Depression
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Ketamine for Veterans With Parkinson's Disease
NCT06231563
Recruiting
Parkinson's disease (PD) is a devastating illness that has a growing impact on Veterans. One of the most disabling symptoms is depression, which is common in PD and linked to poor quality of life and higher risk of suicide. Unfortunately, there is a lack of effective treatments for depression in PD. Ketamine, which has rapid and potent antidepressant effects, is a potential option but has not been tested in Veterans with PD. Studies in rodents show that ketamine may not only improve depression i... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
04/11/2025
Locations: San Francisco VA Medical Center, San Francisco, CA, San Francisco, California
Conditions: Parkinson's Disease
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Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
NCT02461927
Completed
The investigators will compare 3 treatment groups (ketamine plus naltrexone vs. ketamine alone vs. placebo) for treating major depressive disorder (MDD) and alcohol use disorder (AUD) in an 8-week randomized, double-blind, placebo-controlled, between-subjects trial. First, prior to the double-blind trial, the investigators will conduct an open-label trial that will include 5 patients with comorbid MDD and AUD to test safety and efficacy of repeated ketamine treatment (0.5 mg/kg; once a week for... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
04/09/2025
Locations: VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut
Conditions: Major Depressive Disorder, Alcohol Use Disorder
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The Dreamy Jet Study
NCT06919198
Not Yet Recruiting
The goal of this clinical trial is to see if a device known as a jet-injection system can help deliver a single dose of a sedating medication with less pain and stress than current methods. Participants will receive a dose of the sedative in their arm or thigh before their procedure at the sedation clinic.
Gender:
ALL
Ages:
Between 2 years and 15 years
Trial Updated:
04/02/2025
Locations: University of Wisconsin - Madison, Madison, Wisconsin
Conditions: Sedation, Blood Drawing Procedure, Immunization, IV Placement
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Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIV
NCT06538285
Recruiting
The goal of this clinical trial is to learn whether it is possible to use intramuscular (IM) ketamine in combination with psychotherapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in publicly insured patients with or at-risk for HIV disease. The main questions it aims to answer are: * Do publicly insured patients find ketamine-assisted psychotherapy feasible and acceptable as a potential treatment for MeUD? * Is IM ketamine safe and tolerable among patients with MeUD? Parti... Read More
Gender:
ALL
Ages:
Between 18 years and 69 years
Trial Updated:
04/01/2025
Locations: San Francisco Department of Public Health, San Francicso, California
Conditions: Methamphetamine Use Disorder
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Ketamine Infusion for Neuropathic Pain in Brachial Plexus Injuries
NCT04933149
Enrolling By Invitation
The purpose of this study is to assess pre- and postoperative neuropathic pain in patients with traumatic brachial plexus injuries to determine if intraoperative ketamine infusion affect neuropathic pain associated with avulsion injuries of the brachial plexus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Brachial Plexus Injury
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Paravertebral Nerve Blocks in Neonates
NCT03408340
Terminated
This study is a prospective, randomized, non-blinded clinical trial examining the use of paravertebral peripheral nerve block in the neonatal and infant populations. The primary aim of this study is to determine the feasibility of studying whether a single-shot paravertebral nerve block is effective in providing intraoperative and postoperative pain control in infants undergoing a thoracotomy for coarctation of the aorta. This will be determined by comparing consumption of narcotics, expressed a... Read More
Gender:
ALL
Ages:
12 months and below
Trial Updated:
03/20/2025
Locations: Children's Healthcare of Atlanta, Atlanta, Georgia
Conditions: Congenital Heart Disease
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Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing CarDiac SurgERies
NCT05279898
Completed
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1. reduce the incidence of perioperative neurocognitive dysfunction in cardiac surgical patients 2. ensure hemodynamic stability and decrease use of vasopressors in the operating rooms 3. reduce pain and opioid consumption postoperatively
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/18/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
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Ketamine for Pain Control After Severe Traumatic Injury
NCT04274361
Completed
This study evaluates if the early utilization of ketamine infusion therapy among acutely injured adult trauma hospital inpatients with an ISS \>15 will decrease the amount of opioid pain medication used as compared with placebo group. Ketamine infusion therapy initiated within 12 hours of hospital arrival will lead to decreased total opiate consumption (standardized to oral morphine equivalent units) in the first 24 and 48 hours compared to controls.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/12/2025
Locations: Froedtert Hospital, Milwaukee, Wisconsin
Conditions: Hospital Inpatient Trauma Injury, Pain Management
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