A Study on the Safety of an Investigational Chickenpox Vaccine, When Given to Healthy Children, 12 to 15 Months of Age
Recruiting
The purpose of this study is to assess how well-tolerated GSK's investigational varicella vaccine (VNS Vaccine) is, in comparison to an already approved varicella vaccine (VV) known as Varivax. The study will be conducted on healthy children aged 12 to 15 months, and who have neither contracted varicella nor received a varicella vaccination.
Gender:
ALL
Ages:
Between 12 months and 15 months
Trial Updated:
01/17/2025
Locations: GSK Investigational Site, West Covina, California
Conditions: Chickenpox
A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision
Recruiting
This study is investigating the effects on immune cells of injecting the influenza vaccine (also known as "flu shot") into cutaneous squamous cell carcinoma (CSCC) tumors prior to having standard-of-care Mohs excision surgery. The study will help understand if the addition of the influenza vaccine could improve the immune system response against the cancer. The names of the study drug involved in this study is: -Fluzone Influenza vaccine (flu shot)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/15/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC), Cutaneous Squamous Cell Cancer
Co-administration Study of an Investigational Live-Attenuated Respiratory Syncytial Virus Vaccine in Infants and Toddlers
Active Not Recruiting
This study is a Phase III, randomized, single-blind, placebo-controlled, multi-center study to be conducted in healthy infants and toddlers which will be enrolled at approximately 6 months of age (Cohort 1) and approximately 12 months of age (Cohort 2). The primary objective of the study will be to assess non-inferiority of the RSV infant and toddler (RSVt) vaccine antibody response when administered concomitantly with routine pediatric vaccines at 6 months of age (Diphtheria and Tetanus Toxoids... Read More
Gender:
ALL
Ages:
Between 6 months and 12 months
Trial Updated:
01/13/2025
Locations: Alabama Clinical Therapeutics - Birmingham - St. Vincent's Drive- Site Number : 8400007, Birmingham, Alabama +66 locations
Conditions: RSV Immunization
Study of an Investigational Pentavalent Meningococcal ABCYW Vaccine in Adults and Adolescents
Active Not Recruiting
The purpose of VAN00010 study is to assess the safety and immunogenicity of the investigational pentavalent meningococcal ABCYW vaccine in adults and adolescents. The study duration will be up to 12 months for all participants.
Gender:
ALL
Ages:
Between 10 years and 25 years
Trial Updated:
01/10/2025
Locations: Accel Research Site - Birmingham Clinical Research Unit- Site Number : 8400080, Birmingham, Alabama +46 locations
Conditions: Healthy Volunteers, Meningococcal Immunisation
Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma
Active Not Recruiting
This is a single institution, open-label, single arm, study assessing the safety, feasibility, and immunogenicity of a personalized neoantigen-based vaccine in subjects with newly diagnosed, unmethylated glioblastoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Glioblastoma
Systems Biological Assessment of Statin Effect on Vaccine Responses
Completed
This study is being done to answer the question: Does the use of statin lipid-lowering medication change the effect of influenza vaccine? The research team will use the knowledge gained from answering this question to understand how this medication affects long-lasting immune responses to vaccines. The researchers will study the immune response to the influenza vaccine in the blood (where antibodies are). The team will also look at how statin therapy affects the bacteria that live in the gut by... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
01/06/2025
Locations: Hope Clinic, Atlanta, Georgia
Conditions: Vaccine Response
A Synthetic MVA-based SARS-CoV-2 Vaccine, GEO-CM04S1, for the Prevention of COVID-19 Infection
Active Not Recruiting
This phase I trial evaluates the side effects and best dose of GEO-CM04S1 (previously designated as COH04S1), a synthetic modified vaccinia Ankara (MVA)-based SARS-CoV-2 vaccine, for the prevention of COVID-19 infection. COVID-19 infection is caused by the SARS-CoV-2 virus. SARS-CoV-2 has demonstrated the capability to spread rapidly, leading to significant impacts on healthcare systems and causing societal disruption. GEO-CM04S1 was created by placing small pieces of SARS-CoV-2 DNA (the chemica... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/02/2025
Locations: EmVenio Research, Claremont, California +2 locations
Conditions: COVID-19 Infection
A Study to Learn About the Safety and Immune Response of a New Pneumococcal Vaccine in Adults
Active Not Recruiting
The purpose of this study is to learn about the safety and immune effects of a pneumococcal vaccine in adults. This vaccine can possibly provide protection against further pneumococcal disease. This study will happen in 3 stages: Stage 1 is seeking participants who are between 18 years to 49 years of age. The participants will receive 1 of 2 pneumococcal vaccine candidates (different formulations) or 20vPnC (Prevnar 20) as a single shot given into the upper arm muscle. Stage 2 will begin after... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/23/2024
Locations: Alliance for Multispecialty Research, LLC, Coral Gables, Florida +16 locations
Conditions: Pneumococcal Disease
Pilot Study With CY, Pembrolizumab, GVAX, and IMC-CS4 (LY3022855) in Patients With Borderline Resectable Adenocarcinoma of the Pancreas
Completed
The purpose of this study is to evaluate whether combining cyclophosphamide (CY), pembrolizumab, GVAX and IMC-CS4 is effective and safe in patients with borderline resectable pancreatic cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/23/2024
Locations: Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: Pancreatic Cancer
A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults
Completed
The study is divided into 2 parts: Part 1 and Part 2. The purpose of Part 1 of this study is to generate sufficient safety, reactogenicity, and immunogenicity data to enable selection of an mRNA-1083 vaccine composition and dose level to evaluate in a subsequent Phase 3 clinical trial in adults. The purpose of Part 2 of this study is to generate safety and immunogenicity data for additional mRNA-1083 compositions and dose levels in young adults ≥18 years and \<50 years of age.
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
12/21/2024
Locations: Chandler Clinical Trials, Chandler, Arizona +68 locations
Conditions: SARS-CoV-2, Influenza
A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older
Completed
The purpose of this study is to evaluate the safety and efficacy of mRNA-1010 in preventing seasonal influenza in adults 50 years and older.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
12/20/2024
Locations: North Alabama Research Center, LLC, Athens, Alabama +232 locations
Conditions: Seasonal Influenza
Post-marketing Safety of Elasomeran/Davesomeran and Andusomeran
Completed
The main objective of the study is to evaluate the safety of the elasomeran/davesomeran and andusomeran vaccines as used in routine clinical practice.
Gender:
ALL
Ages:
All
Trial Updated:
12/17/2024
Locations: Aetion, Inc, New York, New York
Conditions: SARS-CoV-2