Effectiveness of and Immune Response to HIV Vaccination Followed by Treatment Interruption in HIV Infected Patients
NCT00080106
Completed
HIV vaccines may help the immune systems of HIV infected patients better control the virus. The goal of this study is to determine whether patients on anti-HIV medications can stop taking those medications if they receive an HIV vaccine. While taking anti-HIV medications, participants will receive either an HIV vaccine or a placebo. Participants will then stop taking their anti-HIV medications and the study will compare the viral loads of participants who received the vaccine with the viral load... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
11/04/2021
Locations: UCLA CARE Center CRS, Los Angeles, California +27 locations
Conditions: HIV Infections
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Quadrivalent HPV Vaccine to Prevent Anal HPV in HIV-infected Men and Women
NCT01461096
Completed
Men who have sex with men (MSM) have an increased risk of developing anal human papillomavirus (HPV) infections, which can be a risk factor for anal cancer. HIV-infected women are also at risk of anal cancer. This study will evaluate the effectiveness of the Food and Drug Administration (FDA)-approved quadrivalent HPV vaccine, Gardasil, at preventing anal HPV infection in HIV-infected MSM and HIV-infected women.
Gender:
ALL
Ages:
27 years and above
Trial Updated:
10/29/2021
Locations: UCLA CARE Center CRS, Los Angeles, California +23 locations
Conditions: HIV Infections
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Immune System Function Following Vaccination in HIV Infected Children Taking Anti-HIV Drugs
NCT00257127
Completed
The purpose of this study is to determine immune system function following vaccination in HIV-infected children currently taking anti-HIV drugs. To test the effectiveness of prior vaccination, patients in this study will receive booster shots of one of two pneumococcal vaccines, a hepatitis B vaccine, and a measles vaccine.
Gender:
ALL
Ages:
Between 6 years and 23 years
Trial Updated:
10/28/2021
Locations: UAB, Dept. of Ped., Div. of Infectious Diseases, Birmingham, Alabama +25 locations
Conditions: HIV Infections
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Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors
NCT02747407
Completed
This research trial studies qualitative, qualitative, and functional studies over the first year in measuring immune system response in patients with brain tumors. Measuring the number of immune cells, whether these immune cells work correctly, and response to 2 vaccines at several times during the first year of treatment may help find out how active the immune system responds to fight infection and cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2021
Locations: Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina
Conditions: Astrocytoma, Glioma, Oligodendroglioma
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Evaluating the Safety of and Immune Response to an HIV Vaccine Followed by Booster, Administered by Two Devices, in HIV-Uninfected Adults
NCT01260727
Completed
The purpose of this study is to evaluate the safety of and immune response to an HIV vaccine, administered using two different devices, followed by a vaccine boost, in healthy, HIV-uninfected adults.
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
10/28/2021
Locations: Rockville Vaccine Assessment Clinic (RVAC), Rockville, Maryland +3 locations
Conditions: HIV Infections
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Pneumococcal Vaccine and Routine Pediatric Immunizations in HIV-Infected Children Receiving Anti-HIV Drugs
NCT00013871
Completed
The purpose of this study is to determine if 2 doses of Pneumococcal Conjugate Vaccine (PCV) followed by 1 dose of Pneumococcal Polysaccharide Vaccine (PPV) in HIV-infected children on anti-HIV therapy is helpful and safe in fighting pneumococcal infections in this group of children. This study will also look at the protection provided by childhood vaccination against measles, pertussis, and hepatitis B virus. Pneumococcal infections are the most common AIDS-related infection in HIV-infected ch... Read More
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
10/28/2021
Locations: UAB, Dept. of Ped., Div. of Infectious Diseases, Birmingham, Alabama +39 locations
Conditions: HIV Infections, Hepatitis B, Measles, Pneumococcal Infections, Pertussis
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Safety of and Immune Response to Two Influenza Vaccines in HIV Infected Children and Adolescents
NCT00091702
Completed
The purpose of this study is to compare two flu vaccines to determine their safety and ability to stimulate an immune response in HIV infected children and adolescents. This study will also determine how often and how long people who receive a vaccine are able to spread flu vaccine virus to other people.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
10/28/2021
Locations: UAB, Dept. of Ped., Div. of Infectious Diseases, Birmingham, Alabama +60 locations
Conditions: HIV Infections, Influenza
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A Phase I Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety and Immunogenicity of HIV-1 Recombinant Envelope Glycoprotein gp160
NCT00000745
Completed
To determine the reactivity and safety of HIV-1 recombinant envelope glycoprotein gp160. To determine the immunogenicity of gp160. Although recent advances have been made in antiviral therapy against AIDS, there is currently no cure. It is likely that ultimate control of the disease will depend on the development of safe and effective vaccines against HIV.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
10/27/2021
Locations: JHU AVEG, Pittsburgh, Pennsylvania +1 locations
Conditions: HIV Infections
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A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of a Recombinant Vaccinia-HIV-1 IIIB Env/Gag/Pol Vaccine (TBC-3B)
NCT00000767
Completed
To evaluate, in healthy HIV-1 seronegative vaccinia-immune and vaccinia-naive volunteers, the safety and immunogenicity of an HIV-1 candidate vaccine (TBC-3B) consisting of a live recombinant vaccinia virus expressing the env, gag, and pol genes of HIV-1 IIIB strain. To evaluate the potential of boosting with one of a variety of HIV-1 recombinant subunit, peptide, or pseudovirion vaccines, if available, to augment the immune responses of the vaccinees. Antigenic drift, defined as the genetic va... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/27/2021
Locations: St. Louis Univ. School of Medicine AVEG, Saint Louis, Missouri +4 locations
Conditions: HIV Infections
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A Phase I/II Study of Delayed-Type Hypersensitivity (DTH) Reactions to Intradermal HIV Envelope Antigen
NCT00000782
Completed
To determine the frequency of delayed-type hypersensitivity (DTH) reactions in HIV-positive patients to two doses of two envelope glycoprotein antigens prepared differently. To determine whether patients who have previously demonstrated a DTH response to intradermal MGStage HIV-1 gp160 IIIB baculovirus (MicroGeneSys) have a reproducible response to a repeat injection of gp160 and whether there is cross-reactivity to intradermal HIV-1 rgp160 IIIB vero cell expressed (Immuno-AG). PER 4/5/95 AMEND... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/27/2021
Locations: Stanford CRS, Palo Alto, California +3 locations
Conditions: HIV Infections
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A Double-Blind Placebo-Controlled Trial of the Safety and Immunogenicity of a Seven Valent Pneumococcal Conjugate Vaccine in Presumed HIV-Infected Infants
NCT00000829
Completed
To assess whether HIV-infected infants who receive a heptavalent pneumococcal conjugate vaccine have more local reactions at the site of injection and systemic reactions than placebo subjects. To assess whether this vaccine is more immunogenic than placebo following the third vaccination. Children with HIV infection are at increased risk for invasive pneumococcal infection, particularly bacteremia. A large proportion of pneumococcal disease is caused by a limited number of serotypes. The maximu... Read More
Gender:
ALL
Ages:
Between 2 months and 6 months
Trial Updated:
10/27/2021
Locations: Usc La Nichd Crs, Los Angeles, California +32 locations
Conditions: HIV Infections, Pneumococcal Infections
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A Study to Test If Giving Remune (an HIV Vaccine) Can Improve the Immune Systems of HIV-Positive Patients Who Are Also Participating in ACTG 328
NCT00000943
Completed
The purpose of this study is to determine the effects of an HIV vaccine (Remune) on the immune system. This study involves patients who have received at least 60 weeks of anti-HIV therapy, either alone or in combination with IL-2, while enrolled in ACTG 328. Remune is an experimental HIV vaccine. To see how the body's immune system reacts, this vaccine will be given with 1 to 3 other vaccines, and skin tests will monitor the body's reaction.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/27/2021
Locations: Univ. of Iowa Healthcare, Div. of Infectious Diseases, Iowa City, Iowa +1 locations
Conditions: HIV Infections
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