H5N1 Vaccine Intramuscular Versus Intradermal in Healthy Adults
NCT00310206
Completed
The purpose of this research study is to compare how the body reacts to different strengths of an H5N1 flu vaccine when given by different routes of injection (injection into the skin or into the muscle). It will also compare how antibodies (proteins produced by the body's immune system that recognize and help fight infections and other foreign substances in the body) are made after receiving the H5N1 flu vaccine. Participants will include 100 healthy adults, ages 18-40 years. Study procedures i... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
05/30/2013
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Influenza
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Vaccine Therapy in Treating Patients With Stage II or Stage III Colon Cancer That Has Been Removed During Surgery
NCT00016133
Completed
RATIONALE: Vaccines made from a patient's white blood cells and tumor cells may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining vaccine therapy with chemotherapy may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of vaccine therapy combined with leucovorin and fluorouracil in treating patients who have undergone surgery to completely rem... Read More
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
05/29/2013
Locations: John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown, Pennsylvania +1 locations
Conditions: Colorectal Cancer
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Study of Fluzone® Influenza Virus Vaccine 2011-2012 Formulation (Intramuscular Route) Among Adults
NCT01430819
Completed
The aim of the study is to evaluate the safety and immunogenicity of the 2011-2012 formulation of Fluzone and Fluzone High-Dose vaccines in participants aged 65 years and older. Objectives: * To describe the safety of Fluzone vaccine and Fluzone High-Dose vaccine among adults ≥ 65 years of age. * To describe the immunogenicity of Fluzone vaccine and Fluzone High-Dose vaccine among adults ≥ 65 years of age.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
05/16/2013
Locations: Not set, Colorado Springs, Colorado +5 locations
Conditions: Influenza
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Vaccine Therapy With or Without Sargramostim in Treating Patients With Cancer
NCT00009958
Terminated
Phase I trial to compare the effectiveness of vaccine therapy with or without sargramostim in treating patients who have solid tumors. Vaccines may make the body build an immune response to kill tumor cells. Combining colony-stimulating factors such as sargramostim with vaccines may kill more tumor cells.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2013
Locations: Lombardi Comprehensive Cancer Center at Georgetown University, Washington, District of Columbia
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
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Vaccine Therapy, Tretinoin, and Cyclophosphamide in Treating Patients With Metastatic Lung Cancer
NCT00601796
Completed
The purpose of this study is to find out what effects (good and/or bad) a tumor vaccine used in combination with two drugs (ATRA and cytoxan) have on the patient and their cancer. We also want to find out if the vaccine and the drugs can boost the patient's immune system and how their immune system reacts, both before and after the vaccine treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2013
Locations: H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Conditions: Lung Cancer
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Study to Evaluate the Safety of Novartis MenACWY Conjugate Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants
NCT00806195
Completed
The primary objective of this phase 3b study is to evaluate the safety and tolerability of Novartis MenACWY conjugate vaccine when administered with routine infant vaccinations to healthy infants
Gender:
ALL
Ages:
Between 55 days and 89 days
Trial Updated:
05/13/2013
Locations: 6 Alabama Clinical Therapeutics 806 St. Vincent's Drive, Ste 615, Birmingham, Alabama +152 locations
Conditions: Meningitis, Meningococcal Infection
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Optimizing Influenza Vaccination in Surgical Oncology Patients
NCT01698177
Unknown
Seasonal influenza (flu) is a significant and sometimes serious health issue in the U.S. The Centers for Disease Control (CDC) estimates that over 200,000 people are hospitalized in the U.S each year related to the flu. Public health campaigns advocate widespread vaccination for the flu, and especially for high risk people. People with cancer are high risk, with an increased risk of developing complications from the flu, such as pneumonia, bronchitis, or worsening of other medical conditions. As... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2013
Locations: Stony Brook Hospital, Stony Brook, New York
Conditions: Influenza
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Sanofi Pasteur, TIV + H1N1, Pediatric Population
NCT00943202
Completed
The purpose of this study is to assess the safety and immune response (body's defense against disease) to an experimental H1N1 influenza vaccine against the 2009 H1N1 virus. This study will help determine how and when the H1N1 flu shot should be given with the seasonal flu shot to make it most effective. The 650 participants will be divided into the following age groups: infants from 6 months-36 months old, children 36 months-9 years old, and adolescents 10-17 years old. Each age group will have... Read More
Gender:
ALL
Ages:
Between 6 months and 17 years
Trial Updated:
04/11/2013
Locations: Emory Children's Center - Pediatric Infectious Diseases, Atlanta, Georgia +7 locations
Conditions: Influenza
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Vaccine Therapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer
NCT00003386
Terminated
RATIONALE: Vaccines made from tumor tissue may make the body build an immune response and kill tumor cells. PURPOSE: Phase II trial to study the effectiveness of vaccine therapy in treating patients who have stage III or stage IV ovarian epithelial cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/10/2013
Locations: University of Alabama Comprehensive Cancer Center, Birmingham, Alabama +59 locations
Conditions: Ovarian Cancer
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Vaccine Therapy in Treating Women With Metastatic Breast Cancer
NCT00003184
Completed
RATIONALE: Vaccines made from breast cancer cells may make the body build an immune response to kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of vaccines made from breast cancer cells in treating women with metastatic breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/02/2013
Locations: Earle A. Chiles Research Institute at Providence Portland Medical Center, Portland, Oregon
Conditions: Breast Cancer
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Higher Dose Intradermal H5 Vaccine
NCT00439335
Completed
This study will compare the influenza A/H5N1 virus vaccine given by injection in the muscle versus injection in the skin in healthy adults. The study will look at the safety of the injections, how the body reacts, and what the body's immune response does when the vaccine is given in the muscle versus in the skin. The study will look at 226 healthy volunteers, ages 18-49 years old. Study procedures will include getting 2 doses of vaccine 28 days apart, physical exams, follow-up clinic visits to c... Read More
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
03/28/2013
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Influenza
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Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma
NCT00104845
Completed
RATIONALE: Vaccines made from DNA may make the body build an effective immune response to kill tumor cells. PURPOSE: This randomized phase I trial is studying the side effects and best dose of vaccine therapy in treating patients with stage IIB, stage IIC, stage III, or stage IV melanoma.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2013
Locations: Memorial Sloan-Kettering Cancer Center, New York, New York
Conditions: Melanoma (Skin)
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