Study Evaluating Pneumococcal Vaccine in Healthy Infants
NCT00205803
Completed
The purpose of this study is to evaluate the safety and immunogenicity of the 13-valent pneumococcal conjugate vaccine (13vPnC) in healthy infants. This is the first study with this vaccine in infants.
Gender:
ALL
Ages:
Between 42 days and 98 days
Trial Updated:
07/06/2012
Locations: Not set, New York, New York
Conditions: Healthy Subjects, Pneumococcal Infections
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Vaccine Therapy in Preventing Cytomegalovirus in Healthy Participants
NCT00722839
Completed
RATIONALE: Vaccines made from peptides may help the body build an immune response to kill cytomegalovirus. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in preventing cytomegalovirus in healthy participants.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/21/2012
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: Nonneoplastic Condition
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S0122: Combination Chemotherapy, Radiation Therapy, and Vaccine Therapy in Limited-Stage Small Cell Lung Cancer
NCT00045617
Terminated
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. Vaccines may make the body build an immune response to kill tumor cells. Combining chemotherapy and radiation therapy with vaccine therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy and radiation therapy with vaccine therapy in treating patients who hav... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2012
Locations: MBCCOP - Gulf Coast, Mobile, Alabama +99 locations
Conditions: Lung Cancer
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Study of Anti-HIV Therapy Intensification
NCT00034086
Completed
The purpose of this study is to see how the body's immune system changes after replacing and adding new anti-HIV drugs to a patient's current anti-HIV therapy. This study will also see whether adding drugs is safe. Patients who take part in A5136 are also eligible to take part in 2 substudies. The purpose of substudy A5140s is to see how many latently infected cells (cells in which the HIV virus survives) are in the lymph node (small, rounded structures that make disease-fighting cells). Substud... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/17/2012
Locations: University of Colorado Hospital CRS, Aurora, Colorado +2 locations
Conditions: HIV Infections
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NicVAX/Placebo as an Aid for Smoking Cessation
NCT00836199
Completed
The purpose of this study is to evaluate NicVAX as an aid to smoking cessation for long term abstinence.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/08/2012
Locations: NicVAX Investigator, Tucson, Arizona +21 locations
Conditions: Smoking Cessation, Smoking, Tobacco Cessation
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A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation
NCT01102114
Completed
The purpose of this study is to evaluate NicVAX as an aid to smoking cessation for long term abstinence.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/08/2012
Locations: NicVAX Investigator, Encino, California +24 locations
Conditions: Smoking Cessation
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Study of Different Formulations of an Intramuscular A/H5N1 Inactivated, Split Virion Influenza Adjuvanted Vaccine
NCT00664417
Completed
Following the licensure of sanofi pasteur's 90 µg rgA/Vietnam/1203/2004 pandemic influenza vaccine, efforts to develop a lower antigen dose formulation with improved immunogenicity using adjuvants were initiated. The present study is part of this endeavor. It is primarily a formulation/dose-finding study with a secondary aim at generating safety and immunogenicity data for the final formulation for the development of a pre-pandemic vaccine.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/16/2012
Locations: Not set, San Diego, California +5 locations
Conditions: Influenza, Orthomyxoviridae Infections
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Study of Inactivated, Split-Virion Influenza Vaccine Compared With Standard Fluzone Vaccine in Elderly Subjects
NCT00388583
Completed
As a result of the safety and immunogenicity data generated from earlier dose-ranging studies, the present formulation has been selected for further development in the elderly. Primary Objective: To compare the immunogenicity in subjects receiving investigational Fluzone with those of subjects receiving standard Fluzone®. Secondary Objectives: Immunogenicity: To describe the immunogenicity in subjects receiving investigational Fluzone and standard Fluzone®. Safety: To evaluate and describ... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/13/2012
Locations: Not set, Alabaster, Alabama +16 locations
Conditions: Orthomyxoviridae Infection, Influenza, Myxovirus Infection
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Safety, Tolerability, and Immunogenicity of a Clostridium Difficile Toxoid Vaccine in Healthy Elderly Volunteers
NCT00214461
Completed
The purpose of this study is to determine the safety and tolerability of a modified C. difficile vaccine at 3 dose levels compared with a placebo control administered via intramuscular injection in healthy elderly subjects aged \> or = 65 years. This is the companion study to H-030-008, in which healthy younger adults have already been dosed.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/09/2012
Locations: Orlando Clinical Research Center, Orlando, Florida +1 locations
Conditions: Clostridium Infections
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School Influenza Vaccine vs Standard of Care With Nested Trial of 2 Parent Notification Intensities
NCT01224301
Completed
Purpose of the study. The purpose of the project is to evaluate the feasibility, acceptability, and cost effectiveness of providing influenza vaccine in schools to children in grades Kindergarten through 6th grade. Hypothesis 1: School based influenza vaccination (SIV) will increase the overall rate of influenza vaccination in school children. Hypothesis 2: Higher intensity parent notification about school based influenza vaccination does not increase immunization rates compared to low intensi... Read More
Gender:
ALL
Ages:
Between 4 years and 13 years
Trial Updated:
04/03/2012
Locations: Monroe County Department of Public Health, Rochester, New York
Conditions: Immunizations, Vaccination, Influenza, School Health
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Vaccine and Chemotherapy for Previously Untreated Metastatic Breast Cancer
NCT00048893
Terminated
This study will evaluate the effectiveness of chemotherapy and a combination of vaccines to treat metastatic breast cancer (breast cancer that has spread beyond the breast) in patients whose cancer cells have a protein called carcinoembryonic antigen (CEA) on their surface. Patients who require surgery or radiation therapy, or both, will receive these treatments as well. Patients 18 years of age and older with previously untreated metastatic breast cancer may be eligible for this study. Newly d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2012
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland +1 locations
Conditions: Breast Neoplasms, Metastases, Neoplasm
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Pneumococcal Conjugate Vaccine With Pneumococcal Polysaccharide Vaccine and Tetanus/Diphtheria Vaccine
NCT00164411
Completed
The purpose of this study is to learn whether or not giving a tetanus/diphtheria vaccination ("tetanus shot") before giving pneumococcal vaccine makes the pneumococcal vaccine more effective without causing too many side effects.
Gender:
ALL
Ages:
Between 50 years and 64 years
Trial Updated:
03/13/2012
Locations: Emory University School of Medicine, Atlanta, Georgia
Conditions: Pneumococcal Infections
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