Ohio is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Exparel and Education to Avoid Opioids After Carpal Tunnel Release
NCT03867539
Recruiting
This trial seeks to use the long acting local anesthetic Exparel, in conjunction with opioid education, to attempt to avoid any post-operative opioid use following carpal tunnel surgery. This group will be compared with a "standard" group that receives non-liposomal bupivacaine, opioid education, and opioids.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Orthopedic Associates of Southwest Ohio, Dayton, Ohio
Conditions: Carpal Tunnel Syndrome
Register for Updates
Single Blinded First CMC Osteoarthritis Treatment
NCT03196310
Recruiting
Single blinded PRP vs. Corticosteroid vs. Placebo (normal saline) intra-articular injection for basal joint arthritis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Orthopedic Associates of Southwest Ohio, Centerville, Ohio
Conditions: Osteoarthritis Thumb
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Pilot Study Evaluating the Elasticity and Shear Wave Modulus (Stiffness) of the Median Nerve in Patients With Mild to Moderate Idiopathic Carpal Tunnel Syndrome Receiving OMT and Conservative Therapy
NCT06150443
Recruiting
To evaluate and quantify changes in the elasticity and shear wave modulus (stiffness) of the median nerve in patients diagnosed with mild to moderate carpal tunnel syndrome following osteopathic manipulative therapy.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/25/2024
Locations: Kettering Health, Dayton, Ohio
Conditions: Carpal Tunnel Syndrome
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Migraine Manager (R01)
NCT04567355
Recruiting
The objective of this trial is to test whether an online tailored intervention, Migraine Manager, is efficacious in improving headache outcomes compared to an attention control intervention in adolescents with migraines. We will conduct a randomized clinical trial to compare a sample of 80 youth (ages 11 to 17) with migraine receiving the online tailored adherence intervention to 80 youth in an attention control group. We will test whether adherence to healthy habit (hydration, regular meals, ex... Read More
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
03/25/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Migraine, Migraine Disorders
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Impact of XDEMVY® on Demodex Blepharitis in Soft Contact Lens Wearers
NCT06182358
Recruiting
To compare the efficacy of XDEMVY ophthalmic drop to its vehicle control for the treatment of Demodex blepharitis and its impact on the soft contact lens wearing experience.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/22/2024
Locations: Site, Powell, Ohio
Conditions: Demodex Blepharitis
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Non-randomized Observational Study to Evaluate ReX® in the Management of Solid Oral Medication.
NCT06335758
Recruiting
The goal of this observational study is to evaluate the safety, efficacy and patient satisfaction with the ReX Remote Digital Nurse by patients receiving solid oral medication. The study will evaluate and monitor use of ReX in respect of: * treatment duration * adverse events * patient adherence and compliance * engagement with ReX via patient-reported outcomes Patients participating in the study will receive their normal medication as standard of care via ReX. Progress will be monitored via... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/21/2024
Locations: OHC, Cincinnati, Ohio
Conditions: Any Solid Oral Medication
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Placebo-Controlled, Single-Dose Challenge Study of Gaboxadol in Adult Males With Fragile X Syndrome (FXS)
NCT06334419
Recruiting
This is a single dose, placebo-controlled study. Male subjects aged 18 to 40 years (inclusive) with a diagnosis of FXS. Eligible subjects may enroll in this study comprised of two in home and two in clinic visits each 14 days apart, for a total of four visits. Subjects will be given single dose gaboxadol (10 mg) or matched placebo at each of these visits to take orally. Thus, all enrolled subjects will receive placebo at home and in clinic and receive gaboxadol at home and in clinic in a blinded... Read More
Gender:
MALE
Ages:
Between 18 years and 40 years
Trial Updated:
03/19/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Fragile X Syndrome
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A Safety and Tolerability Study of Jaktinib
NCT05279001
Recruiting
This research study is studying a drug called Jaktinib as a possible treatment for Myelofibrosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Site 01, Canton, Ohio
Conditions: Myelofibrosis
Register for Updates
Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
NCT04028492
Recruiting
To investigate the safety and efficacy of tradipitant versus placebo in relieving nausea and other symptoms of gastroparesis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/19/2024
Locations: Vanda Investigational Site, Columbus, Ohio
Conditions: Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
Register for Updates
Continuous Ward Monitoring With the GE Portrait Mobile Monitoring Solution: the COSMOS Trial
NCT06133140
Recruiting
The investigators plan to determine whether unblinded continuous ward monitoring with the GE Portrait Mobile Monitoring Solution and nursing alerts reduces vital sign abnormalities in patients recovering from major noncardiac surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Postoperative Complications
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I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
NCT04488081
Recruiting
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: University Hospital Cleveland Medical Center, Cleveland, Ohio
Conditions: COVID-19
Register for Updates
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Cincinnati, Ohio
Conditions: Neoplasms
Register for Updates