Ohio is currently home to 3201 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
NCT04137900
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: UC Health - University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
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The Acute Burn ResUscitation Multicenter Prospective Trial
NCT04356859
Recruiting
This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: University of Cincinnati College of Medicine, Cincinnati, Ohio
Conditions: Burn Injury
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LE as a Marker for Periprosthetic Joint Infection
NCT05440032
Recruiting
Testing and comparison of a novel point-of-care electrochemical assay to detect and help diagnose periprosthetic joint infection on the hip and knee to the standard of care test
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: JIS Orthopaedics, New Albany, Ohio
Conditions: Prosthetic-joint Infection
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Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
NCT05338697
Recruiting
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Consultants for Clinical Research - Montgomery Office, Cincinnati, Ohio
Conditions: NASH - Nonalcoholic Steatohepatitis
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Wearable Spine Health System for Military Readiness
NCT05944354
Recruiting
The goal of this observational trial is to compare the health history and motion capabilities of participants with low back pain disorders to participants with healthy spines. The main question\[s\] it aims to answer are to: 1. Primary outcomes of this research effort include the development of composite measures or digital biomarkers to track functional recovery over time and predict duty or work status outcomes (return-to-full duty/work, limited duty/work restrictions or medical discharge/lon... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
01/22/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Low Back Pain, Neck Pain
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Have Physical Therapists Attitudes and Beliefs Towards Vital Assessment Changed Following the COVID-19 Pandemic?
NCT05908045
Recruiting
Previous studies prior to the COVID-19 pandemic show that cardiovascular and blood pressure assessment by physical therapists is inadequate or lacking despite prior training. Since the COVID-19 pandemic, assessment of cardiovascular and respiratory function may become more critical as the manifestation of long COVID has become a concern. The purpose of this study is to determine whether physical therapists' attitudes and beliefs towards vital sign assessment have changed following the COVID-19 p... Read More
Gender:
ALL
Ages:
Between 23 years and 100 years
Trial Updated:
01/22/2024
Locations: Youngstown State University, Youngstown, Ohio
Conditions: Vital Signs
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Natural History of Cerebral Palsy Prospective Study
NCT05576948
Recruiting
The study will describe the natural history of cerebral palsy (CP) as children develop over the first 2 years of life.
Gender:
ALL
Ages:
Between 3 months and 24 months
Trial Updated:
01/16/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Cerebral Palsy
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Motor Training for Infants With Cerebral Palsy
NCT04886895
Recruiting
The intervention in this study, Let's Move, is a motor intervention for infants at risk for cerebral palsy. We will test the feasibility and acceptability of the intervention as well as preliminary effectiveness.
Gender:
ALL
Ages:
Between 3 months and 8 months
Trial Updated:
01/16/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Cerebral Palsy
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The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
NCT04343313
Recruiting
The study is a prospective, multi-center, single-arm, non-randomized, Early Feasibility Study (EFS) to evaluate the safety and performance of the Half Moon TMVr System in patients with severe, symptomatic mitral regurgitation, who are at high risk for conventional mitral valve surgery.
Gender:
ALL
Ages:
Between 21 years and 95 years
Trial Updated:
01/10/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Mitral Valve Insufficiency
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Violet Light for the Suppression of Myopia
NCT06110520
Recruiting
The study explores the suppression of myopia via violet light.
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
01/09/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Myopia, Phototherapy
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Coflex PS3 Actual Conditions for Use Study
NCT02555280
Recruiting
A 2 and 5 year evaluation of clinical outcomes in the treatment of degenerative spinal stenosis with concomitant low back pain by decompression with additional stabilization using the coflex® Interlaminar Technology for FDA Actual Conditions of Use Study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: Consulting Orthopaedic Associates, Toledo, Ohio
Conditions: Spinal Stenosis Lumbar
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