Alabama is currently home to 1235 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Acceptance and Commitment Therapy for Depressed People With Spinal Cord Injuries
NCT06233656
Recruiting
Living with spinal cord injury (SCI) can have a significant negative impact on an individual's mental health and restrict participation in personally valued activities and roles. Acceptance and commitment therapy (ACT) is an evidence-based approach that can lessen symptoms of mental health disorders (e.g., depressive symptoms) and improve quality of life through mindfulness and acceptance processes and behavior change processes for valued living. Evidence for ACT for individuals living with SCI,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Depression, Spinal Cord Injuries
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Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation
NCT06169735
Recruiting
The aim of this study is to determine if fluorescence with or without indocyanine green can facilitate safe and accurate thyroid and parathyroid surgery.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/02/2025
Locations: UAB Callahan Eye, Birmingham, Alabama
Conditions: Parathyroid Dysfunction, Adenoma
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DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)
NCT04709705
Recruiting
A randomized, parallel group, active comparator-controlled trial to evaluate the non-inferiority or superiority of Cryopreserved Platelets with Liquid Stored Platelets in controlling blood loss in patients undergoing Cardiopulmonary Bypass Surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: University of Alabama, Birmingham, Alabama
Conditions: Cardiac Surgery
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Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults
NCT04323046
Recruiting
This phase I trial studies the side effects of nivolumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Gender:
ALL
Ages:
Between 6 months and 25 years
Trial Updated:
05/02/2025
Locations: University of Alabama at Birmingham, Children's of Alabama, Birmingham, Alabama
Conditions: Glioblastoma, Malignant Glioma, Recurrent Glioblastoma, Recurrent Malignant Glioma, Recurrent Grade III Glioma, Grade III Glioma
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Refining the Role of Mid-induction Bone Marrow Biopsy in Acute Myeloid Leukemia: A Pilot Study
NCT06323590
Recruiting
The purpose of the study is to observe the outcomes of patients with acute myeloid leukemia who do not receive an immediate second round of chemotherapy after undergoing a standard mid-induction bone marrow biopsy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/01/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Acute Myeloid Leukemia
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The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury
NCT06147258
Recruiting
The aim of this study is to evaluate the therapeutic benefits of a 10-week online coach-guided EEWP on psychosocial health among adults with SCI.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/01/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Spinal Cord Injuries, Transverse Myelitis
Register for Updates
Cardiometabolic Health Intervention Using Movement-to-Music Exercise
NCT05606432
Recruiting
The study aims to test the benefits of a 24-week, cardio-emphasized Movement-to-Music exercise program for reversing cardiometabolic health risk factors compared to asynchronous, standard exercise programs among 132 adult wheelchair users. The targeted cardiometabolic health factors are waist circumference, triglycerides, "good" cholesterol, glucose, and blood pressure. Additionally, a 12-week follow-up phase (weeks 25-36) is included to see whether the gains are maintained.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
05/01/2025
Locations: The University of Alabama at Birmingahm, Birmingham, Alabama
Conditions: Cardiometabolic Risk Factors in Adult Wheelchair Users
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Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA
NCT04955795
Recruiting
This study is designed to examine the efficacy of a brief intervention plus a cognitive-behavioral intervention compared to brief intervention alone to address unhealthy alcohol use and comorbid mental health symptoms to improve HIV outcomes among people living with HIV in Alabama.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/01/2025
Locations: Health Service Center, Anniston, Alabama
Conditions: Hiv, Alcohol Problem
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The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
NCT03509961
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
ALL
Ages:
Between 1 year and 25 years
Trial Updated:
05/01/2025
Locations: Children's of Alabama/University of Alabama in Birmingham(UAB), Birmingham, Alabama
Conditions: B-cell Acute Lymphoblastic Leukemia
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Cabozantinib and Dostarlimab in Recurrent Gynecologic Carcinosarcoma
NCT05559879
Recruiting
Immunotherapy has gained a significant amount of attention recently, but its efficacy as a single agent in gynecological cancers has been disappointing. Pre-clinical evidence supports the combination of using Vascular Endothelial Growth Factors (VEGF) inhibitors with immunotherapy. VEGF inhibitors suppress the activation of tumor-associated macrophages (TAMs) and VEGF has been shown to affect the functional maturation of dendritic cells; therefore, VEGF inhibitors could improve the function of a... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: O'Neal Comprehensive Cancer Center at UAB, Birmingham, Alabama
Conditions: Gynecologic Cancer, Carcinoma, Uterine Cancer, Endometrial Cancer
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Self-Collection of the Pap Smear as Agency: A Novel Way to Improve Refractory Low Cervical Cancer Screening Rates in Rural Alabama
NCT04093388
Recruiting
The purpose of the study is to find out if a self-administered (by the patient) Papanicolaou (Pap) smear is as accurate as a traditional Pap smear administered by a healthcare provider.
Gender:
FEMALE
Ages:
Between 21 years and 65 years
Trial Updated:
04/30/2025
Locations: Cahaba Medical Care - West End, Birmingham, Alabama
Conditions: Cervical Cancer
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The Effects of Virtual Reality Greenspace on Stress Among Adults With Mobility Impairments
NCT06682143
Recruiting
The purpose of this project is to examine the effects of virtual reality greenspace exposure on physiological and affective acute stress responses among adults with mobility impairments.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/29/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Mobility Impairments
Register for Updates