Alabama is currently home to 1235 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
National Adaptive Trial for PTSD Related Insomnia
NCT03668041
Recruiting
Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking medications called trazodone or eszopiclone can help decrease symptoms of insomnia in patients with PTSD. PTSD is a form of intense anxiety which sometimes results from severe trauma. Symptoms may include nightmares, flashbacks, troublesome memories, difficu... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/18/2024
Locations: Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama
Conditions: Insomnia
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Monitoring Early Response to Targeted Therapy in Stage IV HER2+ Breast Cancer Patients with Advanced PET/MR Imaging
NCT04273555
Recruiting
The purpose of the study is to see if a new group of imaging tests can help identify response to stage IV HER2+ breast cancer before treatment.
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
12/17/2024
Locations: The University of Alabama at Birmingham, Birmingham, Alabama
Conditions: HER2-positive Breast Cancer
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A Study of Sovilnesib in Subjects with Ovarian Cancer
NCT06084416
Recruiting
This is a randomized, phase 1b study to assess the safety, tolerability, pharmacokinetics (PK), and efficacy of sovilnesib at different dose levels to establish the Recommended Phase 2 Dose (RP2D) of sovilnesib in subjects with high grade serous ovarian cancer (HGSOC).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: The University of Alabama at Birmingham, Birmingham, Alabama
Conditions: High Grade Serous Adenocarcinoma of Ovary, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Chromosomal Instability
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Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy
NCT05309928
Recruiting
The study design is a prospective phase I pharmacokinetic study focused on dosing of 500 mg oral amoxicillin administration in pregnant women in the 2nd and 3rd trimester.
Gender:
FEMALE
Ages:
Between 16 years and 50 years
Trial Updated:
12/16/2024
Locations: UAB, Birmingham, Alabama
Conditions: Pregnancy Related
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Feasibility of a New Model for Exercise Prescription in Cystic Fibrosis
NCT04075864
Recruiting
The purpose of this protocol is to begin an exercise program combined with behavioral counseling for patients who are hospitalized with a cystic fibrosis exacerbation. The exercise program will begin during the hospital stay. Beginning an exercise program during this period of reduced mobility and isolation may be an ideal time to deliver a structured exercise prescription along with a behavioral program to promote long-term adherence to exercise (structured physical activity) . Hospitalized pat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Cystic Fibrosis
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Rare CFTR Mutation Cell Collection Protocol (RARE)
NCT03161808
Recruiting
Over 1,900 mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein are implicated in causing Cystic Fibrosis (CF). Potential therapies that directly target defective CFTR are being evaluated in important clinical trials, but most target the most common CFTR mutation F508del. Many patients with rare CF mutations are not able to participate in those studies. The RARE study is specifically designed for people with CF caused by rare mutations. Eligible rare m... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
12/16/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Cystic Fibrosis
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Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis
NCT06735924
Recruiting
This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/14/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: MASLD, Metabolic Dysfunction-Associated Steatotic Liver Disease
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Prospective Multisite Study of Quality of Life in Pediatric Intestinal Failure
NCT04629014
Recruiting
This study proposes to quantify and describe the quality of life of children with intestinal failure, and to identify the medical and socio-economic factors that impact this quality of life, using data from multiple multidisciplinary intestinal failure centers across the United States and Canada specializing in the care of these participants.
Gender:
ALL
Ages:
Between 6 months and 25 years
Trial Updated:
12/14/2024
Locations: Children's of Alabama, Birmingham, Alabama
Conditions: Pediatric Intestinal Failure
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Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients with Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection
NCT05656105
Recruiting
This clinical imaging study will use the small molecule translocator protein (TSPO) ligand, Fluorodeoxyglucose(18F)-labeled DPA-714, to visualize and quantify neuroinflammation in individuals with post-acute sequelae of SARS-CoV-2 (PASC) . The brain uptake of DPA-714 will be contrasted with healthy subjects.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/13/2024
Locations: UAB, Birmingham, Alabama
Conditions: SARS CoV-2 Post-Acute Sequelae
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Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma
NCT05632562
Recruiting
This feasibility study will assess the clinical potential of a new imaging approach to detect viable high grade glioma (HGG) in pediatric and adult patients after standard of care radiation therapy (RT) with or without concurrent temozolomide (TMZ). Study participants will undergo simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) with O-(\[2-\[F-18\]fluoroethyl)-L-tyrosine (FET, amino acid transport) and 1H-1-(3-\[F-18\]fluoro-2-hydroxypropyl)-2-nitroimidazole (FMISO... Read More
Gender:
ALL
Ages:
Between 10 years and 89 years
Trial Updated:
12/13/2024
Locations: UAB, Birmingham, Alabama
Conditions: High Grade Glioma
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Neuroinflammation in Asymptomatic Carotid Artery Disease - Imaging Substudy
NCT05238961
Recruiting
This clinical imaging substudy will use the small molecule translocator protein (TSPO) ligand, Fludeoxyglucose(18F)-labeled DPA-714, to compare neuroinflammation in individuals with high or low grade asymptomatic carotid artery stenosis (aCAD) who are participating in the separate Neuroinflammation in Asymptomatic Carotid Artery Disease study lead by Dr. Ron Lazar (IRB-300007806). The positron emission tomography (PET) tracer \[18F\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also kn... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/13/2024
Locations: UAB, Birmingham, Alabama
Conditions: Critical Asymptomatic Carotid Artery Disease, Non-Critical Asymptomatic Carotid Artery Disease
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Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
NCT03759522
Recruiting
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-in... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/13/2024
Locations: University of Alabama at Birmingham Medical Center, Birmingham, Alabama
Conditions: Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
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