Alabama is currently home to 1229 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
ABTECT - Maintenance
NCT05535946
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: University of Alabama -Birmingham, Birmingham, Alabama
Conditions: Ulcerative Colitis
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Valved Graft PMCF Study
NCT04754217
Recruiting
Multicenter, global, prospective, non-randomized, interventional, post-market trial. All subjects enrolled will receive an Abbott Valved Graft device.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: University Hospital - Univ. of Alabama at Birmingham (UAB), Birmingham, Alabama
Conditions: Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection
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A Person-Centered Geotagged Social Networking System to Promote Physical Activity in the Community
NCT05216393
Recruiting
The multilevel socio-ecological barriers to physical activity experienced by people with physical disabilities cut across structures and systems, community, institutions and organizations, interpersonal, and individual levels. Several studies have attempted to understand these barriers and facilitators, but to date, no study or system has attempted to systematically resolve these multilevel barriers and capitalize on the potential facilitators that can increase access to exercise and recreation... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
08/05/2024
Locations: UAB / Lakeshore Research Collaborative, Birmingham, Alabama
Conditions: Physical Inactivity, Disability Physical
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NTX-301 in MDS/AML
NCT04167917
Recruiting
NTX-301 is a DNMT1 inhibitor. The drug is an oral drug with preclinical data that has shown preclinical anti-leukemic efficacy. This is the first clinical trial using NTX-301 in patients with myeloid malignancies.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia
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An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study
NCT06534892
Recruiting
The purpose of this study is: * To investigate the optimal timing for revaccination after the initial RSVPreF3 OA vaccine dose, * To evaluate the long-term immune persistence and safety up to 5 consecutive RSV seasons (approximately 60 months) of a single dose of RSVPreF3 OA vaccine, * To give the opportunity to participants who received only placebo in the RSVOA=ADJ- 006 study, to receive a dose of the RSVPreF3 OA vaccine and collect additional safety information.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/02/2024
Locations: GSK Investigational Site, Birmingham, Alabama
Conditions: Respiratory Syncytial Virus Infections
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Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis
NCT04891640
Recruiting
This randomized pragmatic trial will generate knowledge about strategies used to de-escalate tumor necrosis factor inhibitor (TNFi) therapy in patients with juvenile spondyloarthritis with sustained inactive disease and are treated at one of the 29 participating pediatric healthcare systems. This open label study will be conducted in the setting of routine clinical care and will compare the risk and timing of flare (Aim 1) and patients' lived experiences (Aim 2) across three arms.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
08/02/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Juvenile Spondyloarthritis
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Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
NCT04301843
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Gender:
ALL
Ages:
31 years and below
Trial Updated:
08/02/2024
Locations: University of Alabama, Children's Alabama, Birmingham, Alabama
Conditions: Neuroblastoma
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Prospective Research Rare Kidney Stones (ProRKS)
NCT02780297
Recruiting
The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of ren... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/01/2024
Locations: University of Alabama @ Birmingham, Birmingham, Alabama
Conditions: Hyperoxaluria, Cystinuria, Dent Disease, Lowe Syndrome, Adenine Phosphoribosyltransferase Deficiency
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Improving Gout Care After an ED Visit
NCT06534554
Recruiting
The prevalence of gout has been steadily increasing over several decades and is correlated with the rising burden of obesity, chronic cardiac and renal disease; all conditions overrepresented in the Southeastern U.S. - particularly in African Americans. Through a novel post-emergency department visit intervention, we aim to improve the care patients with gout receive, both during acute exacerbations and long-term. A secondary goal of the project is to concurrently enhance participation of minori... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/30/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Gout
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Functional Consequences of T-bet Expression in Flu-specific Memory B Cells After Live Attenuated Influenza Vaccine (LAIV)
NCT04080245
Recruiting
As yet the investigators do not understand if there are biomarkers of immune protection after the Flumist or Live Attenuated Flu Vaccine (LAIV). Here the investigators test the hypothesis that the T-bet expressing fraction of flu-specific B cells after live attenuated influenza vaccination also serves as an early biomarker of long-lived antibody responses after vaccination. In this study the investigators will be providing the LAIV to up to 10 healthy subjects and assaying their immune response... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/30/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Influenza, Human
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Self-Myofascial Release of the Upper Cervical Muscles
NCT06529991
Recruiting
The primary objective is to examine the influence of the suboccipital muscles on the superficial back line. The investigators will measure the following as part of this objective: * Changes in biomechanical and viscoelastic properties of points within the superficial back fascial train measured by a handheld myotonometer. * Pain pressure threshold measured by algometry. * Ankle range of motion. * Foot plantar pressure changes. All participants will have a 5-minute self-myofascial release inter... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
07/29/2024
Locations: Edward Via College of Osteopathic Medicine-Auburn, Auburn, Alabama
Conditions: Suboccipital Muscles, Superficial Back Line, Myofascial Release
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Predicton of Sepsis Recovery Performance Subtypes Pilot Study
NCT05912413
Recruiting
This study addresses critically ill sepsis patients' current literature reports of ongoing post-hospital discharge weakness and hospital readmissions. This study is aimed at capture and interpretation of a complex set of tests, administered during a subject's sepsis functional recovery trajectory, particularly capturing hospital readmission's effects on survivors' physical function recovery.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/29/2024
Locations: University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama
Conditions: Sepsis
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