There are currently 1018 clinical trials in Aurora, Colorado looking for participants to engage in research studies. Trials are conducted at various facilities, including Children's Hospital Colorado, University of Colorado, University of Colorado Hospital and University of Colorado - Denver. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV
NCT06013579
Recruiting
People aging with HIV are at higher risk for Alzheimer's disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity. Few studies have tested cognitive effects of exercise interventions or examined mechanisms of adherence to long-term exercise among diverse samples of midlife and older people with HIV. The current study will leverage an existing R01 to address these gaps and provide implicat... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
12/04/2024
Locations: University of Colorado Denver, Aurora, Colorado
Conditions: HIV Infections, Cognitive Impairment
Register for Updates
High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in Oncology
NCT04940468
Recruiting
The primary objective of the study is to determine whether dietary intervention to increase fiber and decrease fat reduces C. difficile infection recurrence in a cohort of oncology patients.
Gender:
ALL
Ages:
9 years and above
Trial Updated:
12/03/2024
Locations: Childrens Hospital Colorado, Aurora, Colorado +1 locations
Conditions: Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Acute, Lymphoma, Clostridium Difficile Infection
Register for Updates
A Research Study of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma
NCT05910567
Recruiting
Bleeding from intra-abdominal injuries is a leading cause of traumatic deaths in children. Abdominal CT is the reference standard test for diagnosing intra-abdominal injuries. Compelling reasons exist, however, to both aggressively evaluate injured children for intra-abdominal injuries with CT and to limit abdominal CT evaluation to solely those at non-negligible risk. The focused assessment sonography for trauma (FAST) examination can help focus patient evaluation in just this manner by potenti... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
12/03/2024
Locations: University of Colorado, Anschutz Medical Center and Children's Hospital Colorado, Aurora, Colorado
Conditions: Blunt Trauma to Abdomen, Wounds and Injuries, Abdomen Injury, Abdominal Injury, Abdomen, Acute
Register for Updates
Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.
NCT06357442
Recruiting
The goal of this observational study is to compare endometrial stripe thickness in adolescent and young adult (AYA) patients with a uterus on estrogen replacement therapy using oral progesterone versus the etonogstrel implant for endometrial protection. The main questions it aims to answer are: Aim 1: Characterize the mean endometrial thickness in AYA on estrogen hormone replacement therapy before initiation of progesterone therapy Aim 2: Characterize the mean changes and variability in endom... Read More
Gender:
FEMALE
Ages:
Between 12 years and 25 years
Trial Updated:
12/03/2024
Locations: Childrens Hospital Colorado, Aurora, Colorado
Conditions: Primary Ovarian Insufficiency, Hypogonadotropic Hypogonadism, Hormone Replacement Therapy
Register for Updates
STXBP1 and SYNGAP1 Related Disorders Natural History Study
NCT06555965
Recruiting
The purpose of this study is to find out more about STXBP1 and SYNGAP1 related disorders. The information gathered by this study will be used to prepare for clinical treatment trials. The primary objective of the study is to better define and outline the clinical spectrum of STXBP1 and SYNGAP1 through detailed developmental, seizure, and quality of life assessments as an extension of routine clinical care.
Gender:
ALL
Ages:
All
Trial Updated:
11/27/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Genetic Disease, STXBP1 Encephalopathy With Epilepsy, SYNGAP1-Related Intellectual Disability
Register for Updates
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
NCT06201416
Recruiting
This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower dose levels is shown.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/25/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Rheumatoid Arthritis
Register for Updates
Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
NCT06414096
Recruiting
Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype. Specific Aim: To test the hypothesis that pulsatile IV administration of FSH will rescue the impaired folliculogenesis and relative hypogonadotropic hypogonadism, characteristic of obesity. The investigators will accomplish this by administering a cycle of pulsatile FSH to women with obesity and comparing their... Read More
Gender:
FEMALE
Ages:
Between 19 years and 37 years
Trial Updated:
11/25/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Infertility, Obesity
Register for Updates
A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis
NCT06431373
Recruiting
The purpose of this study is to determine the safety and efficacy of brepocitinib in participants with active, non-anterior (intermediate, posterior, or pan) non-infectious uveitis (NIU).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/25/2024
Locations: Clinical Trial Site, Aurora, Colorado
Conditions: Uveitis, Posterior, Uveitis, Intermediate, Uveitis
Register for Updates
A Study of ZN-c3 in Patients With Ovarian Cancer
NCT04516447
Recruiting
This is a Phase 1b open-label, multicenter study, evaluating the safety, tolerability, preliminary clinical activity, pharmacokinetics (PK), and pharmacodynamics of ZN-c3 in combination with other drugs.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Site 0264, Aurora, Colorado
Conditions: Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
Register for Updates
COMT Inhibition Among Individuals With Comorbid AUD/ADHD
NCT03904498
Recruiting
The purpose of this study is to determine whether the catechol-O-methyltransferase (COMT) inhibitor tolcapone, relative to placebo, affects response to alcohol, decision-making, brain activation associated with alcohol cue reactivity, response inhibition, and selective attention, or alcohol drinking.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
11/20/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Alcohol Use Disorder, Attention Deficit Hyperactivity Disorder
Register for Updates
Brexpiprazole in Alcohol Use Disorder
NCT04066192
Recruiting
Few medications are currently Food \& Drug Administration (FDA)-approved for the treatment of Alcohol Use Disorder (AUD), and those that are have, on average, modest effects on drinking. "Precision medicine" research has explored whether patient-level variables, such as genetic variation, may identify subgroups of individuals with larger medication effects, but few findings have been replicated. A promising novel medication for AUD is brexpiprazole (BREX), a serotonin/dopamine activity modulator... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
11/20/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Alcohol Use Disorder
Register for Updates
Quantitative and Clinical Assessment of Flexor Tendon Gliding Following Application of a Bioresorbable Hydrogel: A Prospective, Randomized Study in Patients Undergoing Distal Radius Fracture Repair
NCT04976335
Recruiting
The investigators will be evaluating the use of versawrap in the setting of distal radius fractures by placing membrane between plate and flexor tendons. Investigators will then evaluate tendon gliding morphology and number of tendon ruptures
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of Colorado Health Hospital, Aurora, Colorado
Conditions: Distal Radius Fracture, Tendon Rupture
Register for Updates